Abstract: Alpha-emitting LIPIODOL® emulsions and their use in treating cancer is disclosed. Radionuclides, including, but not limited to actinium-225 and bismuth-212/lead-212, are incorporated in LIPIODOL® emulsions. The alpha-emitting LIPIODOL® emulsions can be used to treat primary and metastatic liver cancer, including hepatocellular carcinoma (HCC), and metastatic diseases of the liver, as well as lymphatic cancers.

Abstract: An embodiment in accordance with the present invention provides a thermo-chemoembolization formulation and method for enhanced interventional image-guided therapy for cancer. The T-C formulation includes magnetic iron oxide nano-particles (MIONs) that heat when exposed to an alternating magnetic field (AMF), a liquid tumorphilic drug carrier that enhances tumor retention of the T-C formulation, and a chemotherapeutic or radiotherapeutic agent. The T-C formulation enhances delivery of heat and chemo- or radio-therapeutic agents with hyperthermia produced by magnetic nanoparticles to improve therapeutic outcomes. The magnetic nanoparticles and tumorphilic drug carrier also allow for multimodal image-guided monitoring of treatment and patient follow-up. The method for enhanced interventional image-guided therapy for cancer includes using an AMF to heat the T-C formulation and activate the thermotherapy.