Patents by Inventor Eli CHAPMAN

Eli CHAPMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analogs of nitrofuran antibiotics to combat resistance
    Patent number: 12552782
    Abstract: Novel compounds and methods of killing or inhibiting the growth of bacteria.
    Type: Grant
    Filed: January 17, 2023
    Date of Patent: February 17, 2026
    Assignees: THE TRUSTEES OF INDIANA UNIVERSITY, ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Steven Johnson, Eli Chapman
  • AN EIF4A INHIBITOR WITH A NOVEL MECHANISM OF ACTION
    Publication number: 20240360107
    Abstract: The present invention features inhibitors of the eIF4A enzyme. These inhibitors have a novel mechanism for inhibiting the eIF4A enzyme by occupying a binding pocket within the eIF4A RNA-binding groove, thereby perturbing RNA binding, blocking ATP hydrolysis, and, consequently, inhibiting RNA helicase activity. Thus, the compounds of the present invention are RNA-competitive, ATP-uncompetitive elF4A inhibitors that directly bind elF4A and inhibit the protein.
    Type: Application
    Filed: August 30, 2022
    Publication date: October 31, 2024
    Inventors: Eli Chapman, Christopher Zerio
  • COMPOUNDS AND METHODS OF INHIBITING BACTERIAL CHAPERONIN SYSTEMS
    Publication number: 20230406831
    Abstract: The present disclosure relates to compounds and methods of killing or inhibiting the growth of bacteria by disrupting chaperonin-mediated refolding of proteins.
    Type: Application
    Filed: October 26, 2021
    Publication date: December 21, 2023
    Inventors: Steven JOHNSON, Eli CHAPMAN
  • Analogs of Nitrofuran Antibiotics to Combat Resistance
    Publication number: 20230295136
    Abstract: Novel compounds and methods of killing or inhibiting the growth of bacteria.
    Type: Application
    Filed: January 17, 2023
    Publication date: September 21, 2023
    Inventors: Steven Johnson, Eli Chapman
  • INHIBITORS OF HSP70 PROTEINS
    Publication number: 20230091297
    Abstract: Provided are compounds useful for selectively inhibiting HSP70 isoforms. Also provided are methods of inhibiting HSP70 proteins and methods of treating a disease characterized by overexpression of a HSP70, such as cancer. In particular embodiments, the disclosed compounds may be used as potent inhibitors for HSPA5 and may display greater than 20-fold selectivity over other HSP70 isoforms.
    Type: Application
    Filed: March 12, 2021
    Publication date: March 23, 2023
    Inventors: Eli Chapman, Andrew J. Ambrose, Taoda Shi
  • Analogs of Nitrofuran Antibiotics to Combat Resistance
    Publication number: 20220009914
    Abstract: Novel compounds and methods of killing or inhibiting the growth of bacteria.
    Type: Application
    Filed: July 1, 2021
    Publication date: January 13, 2022
    Inventors: Steven Johnson, Eli Chapman
  • INHIBITION OF BACTERIAL CHAPERONIN SYSTEMS
    Publication number: 20210395210
    Abstract: The present disclosure relates to novel compounds and methods of killing or inhibiting the growth of bacteria. In some embodiments, a method of killing or inhibiting the growth of bacteria is provided. The method comprises administering a compound of formula I or a pharmaceutically acceptable salt thereof to bacteria. In some embodiments, a method of killing or inhibiting the growth of bacteria is provided. The method comprises administering an anthelmintic to bacteria.
    Type: Application
    Filed: November 1, 2019
    Publication date: December 23, 2021
    Inventors: Steven JOHNSON, Eli CHAPMAN