Abstract: An oral gel composition suitable for the treatment of oral leukoplakia comprising a combination of diclofenac with hyaluronic acid and methods of administering the oral gel that may include a device that prolongs contact time of the oral gel with the areas of the mucosa that are affected by oral leukoplakia.

Abstract: A method of enhancing absorption of a therapeutic agent sublingually in a person configured to treat chronic graft-versus-host disease (cGVHD) or aphthous stomatitis. The method includes administering a therapeutically effective amount of the therapeutic agent sublingually in a person and then inserting for a predetermined treatment period a device in an oral cavity of the person, wherein the device comprising an oral retention portion that is configured to be retained in the oral cavity from the predetermined treatment period and further configured to enhance absorption of the therapeutic agent sublingually.

Abstract: An oral gel composition suitable for the treatment of oral leukoplakia comprising a combination of diclofenac with hyaluronic acid and methods of administering the oral gel that may include a device that prolongs contact time of the oral gel with the areas of the mucosa that are affected by oral leukoplakia.

Abstract: A method of enhancing absorption of a therapeutic agent sublingually in a person. The method includes administering a therapeutically effective amount of the therapeutic agent sublingually in a person and then inserting for a predetermined treatment period a device in an oral cavity of the person, wherein the device comprising an oral retention portion that is configured to be retained in the oral cavity from the predetermined treatment period and further configured to enhance absorption of the therapeutic agent sublingually.

Abstract: A method and device for the prevention and treatment of oral mucositis using a combination of an anti-mucositis agent and the device that is held in place for prolonged periods of time within the mouth. Portions of the device overlie and are brought into direct contact with the portions of the oral mucosa that are affected by oral mucositis. The method provides prolonged contact time of the anti-mucositis agents to the areas of the mucosa that are affected by oral mucositis. The combination may be used to treat oral mucositis or, prophylactically, to prevent oral mucositis that may occur in patients that receive chemotherapy and/or radiation therapy.

Abstract: An oral gel composition suitable for the treatment of oral leukoplakia comprising a combination of diclofenac with hyaluronic acid and methods of administering the oral gel that may include a device that prolongs contact time of the oral gel with the areas of the mucosa that are affected by oral leukoplakia.

Abstract: Disclosed are methods for the treatment of functional gastrointestinal disorders. The invention involves using proteins that bind to sweet taste receptors in the gastrointestinal tract to modulate noxious symptoms that occur in patients. The methods involve the use of dried whole miracle berry, dried miracle berry juice, miracle berry extract and/or naturally derived or synthetic miraculin protein that is administered in a delayed release capsule or tablet. Use of a delayed release drug delivery system allows miraculin protein, the active ingredient of miracle berry, to bypass destruction in the acid environment of the stomach. This method also allows for the release of larger concentrations of the active ingredient(s) to be applied directly to portions of the gastrointestinal tract that contain specific sweet taste receptors. The method also suggests that other proteins that bind to sweet taste receptors may be used treat these functional gastrointestinal disorders.

Abstract: An oral gel composition suitable for the treatment of oral leukoplakia comprising a combination of diclofenac with hyaluronic acid and methods of administering the oral gel that may include a device that prolongs contact time of the oral gel with the areas of the mucosa that are affected by oral leukoplakia.

Abstract: A method and device for the prevention and treatment of oral mucositis using a combination of an anti-mucositis agent and the device that is held in place for prolonged periods of time within the mouth. Portions of the device overlie and are brought into direct contact with the portions of the oral mucosa that are affected by oral mucositis. The method provides prolonged contact time of the anti-mucositis agents to the areas of the mucosa that are affected by oral mucositis. The combination may be used to treat oral mucositis or, prophylactically, to prevent oral mucositis that may occur in patients that receive chemotherapy and/or radiation therapy.

Abstract: Disclosed are methods for enhancing the efficacy of monoclonal antibody therapy, which entails co-administering a therapeutic monoclonal antibody, or a functional fragment thereof, and an effective amount of colchicine or hydroxychloroquine, or a combination thereof, to a patient in need thereof. Also disclosed are methods of prolonging or increasing the time a monoclonal antibody remains in the circulation of a patient, which entails co-administering a therapeutic monoclonal antibody, or a functional fragment of the monoclonal antibody, and an effective amount of colchicine or hydroxychloroquine, or a combination thereof, to a patient in need thereof, wherein the time the monoclonal antibody remains in the circulation (e.g., blood serum) of the patient is increased relative to the same regimen of administration of the monoclonal antibody but without the co-administration of the effective amount of colchicine and/or hydroxychloroquine.

Abstract: A combination therapy is disclosed for the treatment of a patient, such as a human, with a monoclonal antibody. The methods can include administering to a patient a monoclonal antibody, for example, a TNT-alpha inhibitor such as adalimumab, certolizumab pegol, golimumab, and infliximab; and administering to the patient colchicine. The present teachings also provide a therapeutic combination and a kit including the therapeutic combination.

Abstract: Disclosed is a water-soluble colonoscopy lubricant essentially comprising Polyethylene Glycol 400; Propylene Glycol; and Glycerin. Distilled water may be added as needed to achieve a desired viscosity. Additional ingredients such as a preservative and a pH adjuster may also be added to the colonoscopy lubricant.

Abstract: The invention relates to methods and compositions for the treatment of pruritis ani and other perianal disorders. There are currently few treatments for these conditions, many of which have significant side effects. The methods of the invention involve the administration, in a cream or lotion of pregabalin, an anti-epileptic agent that has pain relieving properties. This topical form of pregabalin may also include the addition of other agents such as immunomodulators, antibiotics or agents that enhance wound healing. This method may be useful as a new and safe treatment for pruritis ani, skin conditions and other anorectal disorders. Previous positive clinical experience suggests that this new treatment is promising for these disorders.

Abstract: The invention relates to methods and compositions for the treatment of constipation. The method of the invention involves administration of a suppository containing chlorophyll, chlorophyllin copper complex or chlorophyllin. The suppository contains an outer layer to prevent spillage of chlorophyll or chlorophyllin prior or after administration. Other ingredients that may also be effective treatments may be included. This method may be useful as a new and safer treatment for constipation, including constipation-predominant IBS and other functional anorectal disorders. Chlorophyll, or chlorophyll copper complex and chlorophyllin in the suppository form may improve bowel activity by stimulation of secretion and motility, thus relieving symptoms of constipation. This is the first description of this unique method of delivering these safe, natural products to patients suffering from constipation.

Abstract: A method for treating or preventing oral cavity mucosal disorders, comprising a step of providing a lozenge containing an antioxidant selected from the group of Vitamin A, Vitamin C, Vitamin E; and other ingredients and a step of placing the lozenge within the oral cavity for a period of time required for dissolution of the lozenge.

Abstract: The invention relates to methods and compositions for the treatment of irritable bowel syndrome (IBS) and other functional gastrointestinal disorders. The methods of the invention involve the administration, in a delayed-release capsule or tablet containing a mixture of peppermint oil and chlorophyll. Other ingredients that may also be effective treatments may be included. This method may be useful as a new and safer treatment for IBS and other functional gastrointestinal disorders. The action of the peppermint oil is effective as a modulator of gastrointestinal motility and sensation. Chlorophyll may improve bowel activity by stimulation of secretion and motility. This is the first description of this unique mixture of these natural products for the treatment of gastrointestinal conditions.

Abstract: A method for treating anorectal disorders, comprising a step of providing a suppository containing between 1000 and 500,000 IU of an antioxidant selected from the group of Vitamin A, Vitamin C, Vitamin E; and a step of placing the suppository within the rectal cavity for a period of time required for dissolution of the suppository.

Abstract: The invention relates to methods and compositions for measuring the rate of gastric emptying in animals, including humans. The methods of the invention measure the rate of stomach emptying by administration of a marker agent in a delayed-release formulation or food vehicle and blood or serum levels of the marker agent are monitored over time. The blood or serum levels of a marker agent reflect the gastric emptying rate. Incorporating such agents in foods also delays the absorption of such agents and serves as a measure of digestion and gastric emptying. These methods may be used to screen for drugs, herbal substances and other compounds that modulate gastric emptying, such as by increasing prokinetic activity of the gastrointestinal tract.