Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.

Abstract: The present disclosure provides improved nucleic acid sequencing-by-synthesis (SBS) methods, related kits and reagents, and systems for performing such methods using such kits and reagents.

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.

Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.

Abstract: Methods, systems, and reagents for real-time single molecule sequencing of nucleic acids, particularly long DNA molecules, is described. Preferably, such methods and systems combine FRET (Förster Resonance Energy Transfer)-based proximity sensing of labeled nucleotides in or near a DNA polymerase's active site with FRET-based monitoring of the conformational changes in the polymerase that occur during nucleotide incorporation.

Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adopted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

Abstract: The present disclosure provides improved nucleic acid sequencing-by-synthesis (SBS) methods, related kits and reagents, and systems for performing such methods using such kits and reagents.

Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.

Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

Abstract: The invention relates to measuring and generating electrical fields downhole. In one embodiment a system is provided that includes an amplifier connected to a first electrode in electrical contact with the Earth via an operative capacitive coupling. An additional electrode and amplifier are disposed in the borehole opposite the first electrode and constitute a first pair of electrodes spaced in a direction orthogonal to the axis. A second electrode is part of a group of counter electrodes spaced from each other and disposed outside the borehole. The first pair of electrodes and the amplifiers are configured to be one of a source that generates an electrical field in a direction substantially orthogonal to the axis of the borehole and a sensor that measures an electric field substantially orthogonal to the axis of the borehole.

Abstract: The invention relates to measuring and generating electrical fields downhole. In one embodiment a system is provided that includes an amplifier connected to a first electrode in electrical contact with the Earth via an operative capacitive coupling. An additional electrode and amplifier are disposed in the borehole opposite the first electrode and constitute a first pair of electrodes spaced in a direction orthogonal to the axis. A second electrode is part of a group of counter electrodes spaced from each other and disposed outside the borehole. The first pair of electrodes and the amplifiers are configured to be one of a source that generates an electrical field in a direction substantially orthogonal to the axis of the borehole and a sensor that measures an electric field substantially orthogonal to the axis of the borehole.

Abstract: Methods, systems, and reagents for real-time single molecule sequencing of nucleic acids, particularly long DNA molecules, is described. Preferably, such methods and systems combine FRET (Förster Resonance Energy Transfer)-based proximity sensing of labeled nucleotides in or near a DNA polymerase's active site with FRET-based monitoring of the conformational changes in the polymerase that occur during nucleotide incorporation.

Abstract: The invention relates to measuring and generating electrical fields downhole. In one embodiment a system is provided that includes an amplifier connected to a first electrode in electrical contact with the Earth via an operative capacitive coupling. An additional electrode and amplifier are disposed in the borehole opposite the first electrode and constitute a first pair of electrodes spaced in a direction orthogonal to the axis. A second electrode is part of a group of counter electrodes spaced from each other and disposed outside the borehole. The first pair of electrodes and the amplifiers are configured to be one of a source that generates an electrical field in a direction substantially orthogonal to the axis of the borehole and a sensor that measures an electric field substantially orthogonal to the axis of the borehole.

Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

Abstract: The invention relates to measuring and generating electrical fields downhole. In one embodiment a system is provided that includes a first electrical conductor within a borehole and in electrical contact with the Earth. An amplifier is connected to the first electrical conductor and a second conductor completes an electrical circuit between the conductors such that the electrical field is oriented in a direction substantially orthogonal to the axis of the borehole.

Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.