Patents by Inventor Eli Weinberg
Eli Weinberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10231820Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: GrantFiled: November 17, 2016Date of Patent: March 19, 2019Assignees: The Charles Stark Draper Laboratory, Inc., The General Hospital CorporationInventors: Joseph P. Vacanti, Young-Moon M. Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad R. Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg
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Publication number: 20170296322Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: ApplicationFiled: November 17, 2016Publication date: October 19, 2017Inventors: Joseph P. Vacanti, Young-Moon M. Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad R. Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg
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Patent number: 9738860Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: GrantFiled: January 13, 2014Date of Patent: August 22, 2017Assignees: The General Hospital Corporation, The Charles Stark Draper Laboratory, Inc.Inventors: Joseph P. Vacanti, Young-Moon M. Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad R. Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg
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Publication number: 20140234953Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: ApplicationFiled: January 13, 2014Publication date: August 21, 2014Applicants: THE GENERAL HOSPITAL CORPORATION, THE CHARLES STARK DRAPER LABORATORYInventors: Joseph P. Vacanti, Young-Moon M. Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad R. Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg
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Patent number: 8642336Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: GrantFiled: May 24, 2010Date of Patent: February 4, 2014Assignees: The General Hospital Corporation, The Charles Stark Draper LaboratoryInventors: Joseph P. Vacanti, Young-Moon Michael Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad Reza Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg
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Patent number: 8491561Abstract: Methods and materials for making an apparatus which duplicates the functionality of a physiological system is provided.Type: GrantFiled: August 16, 2010Date of Patent: July 23, 2013Assignees: The Charles Stark Draper Laboratory, Massachusetts Institute of Technology, The General Hospital CorporationInventors: Jeffrey T. Borenstein, Eli Weinberg, Brian K. Orrick, Eleanor M. Pritchard, Edward J. Barnard, Nicholas J. Krebs, Theodore Marentis, Joseph P. Vacanti, Mohammad Reza Kaazempur-Mofrad
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Patent number: 8460546Abstract: The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.Type: GrantFiled: June 16, 2011Date of Patent: June 11, 2013Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Eli Weinberg, Jeffrey T. Borenstein
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Patent number: 8357528Abstract: The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.Type: GrantFiled: June 9, 2011Date of Patent: January 22, 2013Assignees: The General Hospital Corporation, The Charles Stark Draper LaboratoryInventors: Joseph P. Vacanti, Jeffrey T. Borenstein, Eli Weinberg
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Publication number: 20120118811Abstract: The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.Type: ApplicationFiled: June 16, 2011Publication date: May 17, 2012Applicant: The Charles Stark Draper Laboratory, Inc.Inventors: Eli Weinberg, Jeffrey T. Borenstein
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Patent number: 8147562Abstract: The present invention relates to methods for the design and fabrication of biological constructs, such as organ simulants or organ replacements, which contain complex microfluidic architecture. Designs of the present invention provide increased space in the lateral dimension, enabling a large number of small channels for small vessels.Type: GrantFiled: September 23, 2003Date of Patent: April 3, 2012Assignee: The General Hospital CorporationInventors: Joseph P. Vacanti, Jeffrey Borenstein, Mohammad R. Kaazempur-Mofrad, Eli Weinberg
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Publication number: 20110256619Abstract: The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.Type: ApplicationFiled: June 9, 2011Publication date: October 20, 2011Applicants: The Charles Stark Draper Laboratory, The General Hospital CorporationInventors: Joseph P. Vacanti, Jeffrey T. Borenstein, Eli Weinberg
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Patent number: 7985336Abstract: The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.Type: GrantFiled: August 5, 2010Date of Patent: July 26, 2011Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Eli Weinberg, Jeffrey T. Borenstein
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Patent number: 7960166Abstract: The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.Type: GrantFiled: May 21, 2004Date of Patent: June 14, 2011Assignees: The General Hospital Corporation, The Charles Stark Draper LaboratoryInventors: Joseph P. Vacanti, Jeffrey T. Borenstein, Eli Weinberg
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Publication number: 20110056882Abstract: Methods and materials for making an apparatus which duplicates the functionality of a physiological system is provided.Type: ApplicationFiled: August 16, 2010Publication date: March 10, 2011Applicants: THE CHARLES STARK DRAPER LABORATORY, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE GENERAL HOSPITAL CORPORATIONInventors: Jeffrey T. Borenstein, Eli Weinberg, Brian K. Orrick, Eleanor M. Pritchard, Edward J. Barnard, Nicholas J. Krebs, Theodore Marentis, Joseph P. Vacanti, Mohammad Reza Kaazempur-Mofrad
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Publication number: 20110024346Abstract: The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.Type: ApplicationFiled: August 5, 2010Publication date: February 3, 2011Applicant: The Charles Stark Draper Laboratory, Inc.Inventors: Eli Weinberg, Jeffrey T. Borenstein
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Publication number: 20100267136Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: ApplicationFiled: May 24, 2010Publication date: October 21, 2010Applicants: THE GENERAL HOSPITAL CORPORATION, THE CHARLES STARK DRAPER LABORATORYInventors: Joseph P. Vacanti, Young-Moon Michael Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad Reza Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg
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Patent number: 7790028Abstract: The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.Type: GrantFiled: September 28, 2006Date of Patent: September 7, 2010Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Eli Weinberg, Jeffrey T. Borenstein
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Patent number: 7776021Abstract: Methods and materials for making an apparatus which duplicates the functionality of a physiological system id provided.Type: GrantFiled: November 5, 2004Date of Patent: August 17, 2010Assignees: The Charles Stark Draper Laboratory, Massachusetts Institute of Technology, The General Hospital CorporationInventors: Jeffrey T. Borenstein, Eli Weinberg, Brian K. Orrick, Eleanor M. Pritchard, Edward J. Barnard, Nicholas J. Krebs, Theodore Marentis, Joseph P. Vacanti, Mohammad Reza Kaazempur-Mofrad
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Patent number: 7759113Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: GrantFiled: June 28, 2002Date of Patent: July 20, 2010Assignees: The General Hospital Corporation, The Charles Stark Draper LaboratoryInventors: Joseph P. Vacanti, Young-Moon Michael Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad Reza Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg
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Publication number: 20100098742Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.Type: ApplicationFiled: June 28, 2002Publication date: April 22, 2010Inventors: Joseph P. Vacanti, Young-Moon Michael Shin, Jennifer Ogilvie, Alexander Sevy, Tomoyuki Maemura, Osamu Ishii, Mohammad Reza Kaazempur-Mofrad, Jeffrey T. Borenstein, Kevin R. King, Chiao-Chun Wang, Eli Weinberg