Abstract: A container for transporting an intravenous (IV) bag containing a hazardous substance, such as a chemotherapy drug, includes first and second sidewalls sealed together about a periphery to form an interior having first and second inner compartments, and a third sidewall sealed to a sidewall to form an outer compartment. The container may include features such as a tear strip along a portion of the sealed bottom edge, an access port to the first inner compartment located in at least one of the sidewalls, and biohazard labeling on an outer surface. The first inner compartment and the second inner compartment are contoured for retaining an IV bag and the associated port tubing in a usable position within the container, while the sidewalls are made of a transparent flexible material, and/or partly of a polymer material and partly of a paper material.