Patents by Inventor Eliana B. Gomez

Eliana B. Gomez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
    Patent number: 10702611
    Abstract: Examples may include a method of making a protein-PEG conjugate salt with increased hydrophobicity. The method may include providing an aqueous protein solution. This aqueous protein solution may include a protein and a pH buffer. The method may also include reacting a polyethylene glycol with the protein to form a protein-PEG conjugate. The method may further include protonating an amino group on the protein-PEG conjugate with a hydrophobic organic acid in an organic phase. The protonation may form the protein-PEG conjugate salt having a hydrophobic anion that increases the hydrophobicity-PEG conjugate salt.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: July 7, 2020
    Assignee: Rezolute, Inc.
    Inventors: Mary S. Rosendahl, Sankaram B. Mantripragada, Eliana B. Gomez
  • USE OF HYDROPHOBIC ORGANIC ACIDS TO INCREASE HYDROPHOBICITY OF PROTEINS AND PROTEIN CONJUGATES
    Publication number: 20180318429
    Abstract: Examples may include a method of making a protein-PEG conjugate salt with increased hydrophobicity. The method may include providing an aqueous protein solution. This aqueous protein solution may include a protein and a pH buffer. The method may also include reacting a polyethylene glycol with the protein to form a protein-PEG conjugate. The method may further include protonating an amino group on the protein-PEG conjugate with a hydrophobic organic acid in an organic phase. The protonation may form the protein-PEG conjugate salt having a hydrophobic anion that increases the hydrophobicity-PEG conjugate salt.
    Type: Application
    Filed: July 11, 2018
    Publication date: November 8, 2018
    Applicant: Rezolute, Inc.
    Inventors: Mary S. Rosendahl, Sankaram B. Mantripragada, Eliana B. Gomez
  • Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
    Patent number: 10046058
    Abstract: Examples may include a microsphere. The microsphere may include a biodegradable polymer. Furthermore, the microsphere may include a protein mixture selected from the group consisting of a protein-polyethylene glycol conjugate, the protein-polyethylene glycol conjugate and the hydrophobic anion of the organic acid, a protein and the hydrophobic anion of the organic acid, and combinations thereof. Examples may also include a method of making the microspheres. The method may further include reacting a polyethylene glycol with a protein to form a protein-PEG conjugate. In addition, the method may include protonating an amino group on the protein-PEG conjugate with a hydrophobic organic acid to form the protein-PEG conjugate salt. Furthermore, the method may include mixing the protein-PEG conjugate salt in an organic solvent with a biodegradable polymer. The method may also include emulsifying the mixture.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: August 14, 2018
    Assignee: REZOLUTE, INC.
    Inventors: Mary S. Rosendahl, Sankaram B. Mantripragada, Eliana B. Gomez
  • PROTEINS AND PROTEIN CONJUGATES WITH INCREASED HYDROPHOBICITY
    Publication number: 20160151510
    Abstract: Examples may include a method of making a protein-PEG conjugate salt with increased hydrophobicity. The method may include providing an aqueous protein solution. This aqueous protein solution may include a protein and a pH buffer. The method may also include reacting a polyethylene glycol with the protein to form a protein-PEG conjugate. The method may further include protonating an amino group on the protein-PEG conjugate with a hydrophobic organic acid in an organic phase. The protonation may form the protein-PEG conjugate salt having a hydrophobic anion that increases the hydrophobicity-PEG conjugate salt.
    Type: Application
    Filed: November 30, 2015
    Publication date: June 2, 2016
    Inventors: Mary S. Rosendahl, Sankaram B. Mantripragada, Eliana B. Gomez
  • PROTEINS AND PROTEIN CONJUGATES WITH INCREASED HYDROPHOBICITY
    Publication number: 20160151511
    Abstract: Examples may include a method of making a protein-PEG conjugate salt with increased hydrophobicity. The method may include providing an aqueous protein solution. This aqueous protein solution may include a protein and a pH buffer. The method may also include reacting a polyethylene glycol with the protein to form a protein-PEG conjugate. The method may further include protonating an amino group on the protein-PEG conjugate with a hydrophobic organic acid in an organic phase. The protonation may form the protein-PEG conjugate salt having a hydrophobic anion that increases the hydrophobicity-PEG conjugate salt.
    Type: Application
    Filed: November 30, 2015
    Publication date: June 2, 2016
    Inventors: Mary S. Rosendahl, Sankaram B. Mantripragada, Eliana B. Gomez