Patents by Inventor Eliane Souteyrand
Eliane Souteyrand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10105380Abstract: A molecule responding to formula (I) of the glycocluster type with galactose residues at their extremities. Simple and efficient methods for the preparation of these compounds. Medical use of compounds (I) as inhibitors of infections by Pseudomonas aeruginosa, more specifically as inhibitors of Pseudomonas aeruginosa's virulence.Type: GrantFiled: September 22, 2014Date of Patent: October 23, 2018Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER 1Inventors: Francois Morvan, Jean-Jacques Vasseur, Caroline Ligeour, Yann Chevolot, Eliane Souteyrand, Olivier Vidal, Alice Goudot, Sebastien Vidal
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Publication number: 20160287620Abstract: A molecule responding to formula (I)of the glycocluster type with galactose residues at their extremities. Simple and efficient methods for the preparation of these compounds. Medical use of compounds (I) as inhibitors of infections by Pseudomonas aeruginosa, more specifically as inhibitors of Pseudomonas aeruginosa's virulence.Type: ApplicationFiled: September 22, 2014Publication date: October 6, 2016Inventors: Francois MORVAN, Jean-Jacques VASSEUR, Caroline LIGEOUR, Yann CHEVOLOT, Eliane SOUTEYRAND, Olivier VIDAL, Alice GOUDOT, Sebastien VIDAL
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Patent number: 8183355Abstract: Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistry” reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.Type: GrantFiled: April 7, 2011Date of Patent: May 22, 2012Assignee: Centre National de la Recherche Scientifique (CNRS)Inventors: François Morvan, Albert Meyer, Jean-Jacques Vasseur, Sébastien Vidal, Jean-Pierre Cloarec, Yann Chevolot, Eliane Souteyrand
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Publication number: 20110245478Abstract: Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistry” reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.Type: ApplicationFiled: April 7, 2011Publication date: October 6, 2011Inventors: François Morvan, Albert Meyer, Jean-Jacques Vasseur, Sébastien Vidal, Jean-Pierre Cloarec, Yann Chevolot, Eliane Souteyrand
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Patent number: 7951926Abstract: Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistry” reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.Type: GrantFiled: April 26, 2007Date of Patent: May 31, 2011Assignee: Centre National de la Recherche Scientifique (CNRS)Inventors: François Morvan, Albert Meyer, Jean-Jacques Vasseur, Sébastien Vidal, Jean-Pierre Cloarec, Yann Chevolot, Eliane Souteyrand
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Patent number: 7772010Abstract: A method for mixing and dispensing compounds, at least one reactant in a carrier fluid in laminar flow, and a cell for implementing the method. The cell includes a reaction chamber having a reaction surface where the reactant can be fixed, directly or indirectly, at least three fluid inlets/outlets, a fixed volume reservoir in communication with the reaction chamber and outside the reaction chamber via injection orifice (27), a fluid loop including a feeding port, an extraction port and a variable volume reservoir adapted to communicate independently with the reaction chamber via each of its inlets/outlets; device for circulating fluids in the reaction chamber and the fluid loop. The method and cell can be used to prepare homogeneous surface films, or to carry out “target-probe” identification reactions.Type: GrantFiled: July 12, 2006Date of Patent: August 10, 2010Assignee: Biotray SASInventors: Vincent Dugas, Jérôme Broutin, Eliane Souteyrand
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Patent number: 7700348Abstract: The invention relates to a biochip comprising a substrate presenting a reflecting main surface and wherein the main surface presents localized sites that are made sensitive to fluorescence detection by a transparent layer having optical thickness (2k+1)?/4 where k is a positive or zero integer and where ? designates a wavelength lying between a wavelength ?0 at which fluorescence is excited and a wavelength ?1 at which fluorescence is emitted. The biochip can be manufactured by depositing a transparent layer of thickness m??/2 on a substrate and by making studs or wells of thickness (2k+1)?/4 in said layer to form said sensitive sites.Type: GrantFiled: July 5, 2002Date of Patent: April 20, 2010Assignees: Centre National de la Recherche Scientifique, Ecole Centrale de LyonInventors: Jean René Martin, Michel Garrigues, Marlène Bras, Francois Bessueille, Eliane Souteyrand, Michel Cabrera, Jean-Pierre Cloarec, Jean-Paul Chauvet, Dorothée Chauvet, legal representative, Jean-Michel Chauvet, legal representative, Christophe Chauvet, legal representative
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Publication number: 20090170729Abstract: A method of ex situ fabrication of at least one biochip, the method being of the type consisting in projecting onto a substrate a microvolume of reagent comprising at least one probe diluted in a suitable solvent so as to form, after the solvent has been eliminated, a spot comprising said probe, the method consisting in using a microprojection device comprising at least one tank in which the reagent is stored, and at least one source of gas under pressure put into communication with the tank, and in projecting the microvolume of reagent through an ejection nozzle under drive from the pressure exerted by the gas on the reagent.Type: ApplicationFiled: March 6, 2009Publication date: July 2, 2009Inventors: Michel Cabrera, Mehdi Jaber, Jean-Pierre Cloarec, Jerome Broutin, Eliane Souteyrand, Jean-Rene Martin
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Publication number: 20090124571Abstract: Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistry” reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.Type: ApplicationFiled: April 26, 2007Publication date: May 14, 2009Inventors: Francois Morvan, Albert Meyer, Jean-Jacques Vasseur, Sebastien Vidal, Jean-Pierre Cloarec, Yann Chevolot, Eliane Souteyrand
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Publication number: 20080223115Abstract: A method for mixing and dispensing homogeneous compounds on a surface, at least one reactant in a carrier fluid in laminar flow, and cell (3) for implementing the method. The cell includes reaction chamber (16) having at least one reaction surface (13) where the reactant can be fixed, directly or indirectly, optionally reversibly, at least three fluid inlets/outlets (25, 26), at least one fixed volume reservoir in communication with the reaction chamber and outside the reaction chamber via injection orifice (27), a fluid loop including at least one feeding port, at least one extraction port and at least one reservoir whose volume is variable and adapted to communicate independently with the reaction chamber via each of its inlets/outlets; device for circulating fluids in the reaction chamber and the fluid loop. The method and cell can be used to prepare homogeneous surface films, or to carry out “target-probe” identification reactions.Type: ApplicationFiled: July 12, 2006Publication date: September 18, 2008Applicant: BIOTRAY SASInventors: Vincent Dugas, Jerome Broutin, Eliane Souteyrand
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Patent number: 7303924Abstract: The invention relates to: a method of functionalizing solid supports; the functionalized solid supports thus obtained; and the use thereof, in particular for the immobilization of biological molecules, such as nucleic acids, polypeptides, lipids, carbohydrates and hormones.Type: GrantFiled: July 5, 2002Date of Patent: December 4, 2007Assignee: Centre National de la Recherche ScientifiqueInventors: Vincent Dugas, Yves Chevalier, Eliane Souteyrand
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Patent number: 6979540Abstract: This invention concerns the use, for synthesizing and immobilising nucleic acids, of a solid support modified by an organized self-assembled monolayer of one or several organosilicon compounds. The invention also concerns methods for synthesizing and immobilizing nucleic acids on such a silanized solid support, and DNA chips obtained by said methods.Type: GrantFiled: January 17, 2001Date of Patent: December 27, 2005Assignee: Centre National da la Recherche ScientifiqueInventors: Bernard Benneteau, Jamal Bousbaa, Franck Choplin, Eliane Souteyrand, Jean-René Martin, Jean-Pierre Cloarec
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Publication number: 20050014247Abstract: A method of ex situ fabrication of at least one biochip, the method being of the type consisting in projecting onto a substrate a microvolume of reagent comprising at least one probe diluted in a suitable solvent so as to form, after the solvent has been eliminated, a spot comprising said probe, the method consisting in using a microprojection device comprising at least one tank in which the reagent is stored, and at least one source of gas under pressure put into communication with the tank, and in projecting the microvolume of reagent through an ejection nozzle under drive from the pressure exerted by the gas on the reagent.Type: ApplicationFiled: July 10, 2002Publication date: January 20, 2005Inventors: Michel Cabrera, Mehdi Jaber, Jean-Pierre Clarec, Jerome Broutin, Eliane Souteyrand, Jean-Rene Martin
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Publication number: 20040248122Abstract: The invention relates to a biochip comprising a substrate presenting a reflecting main surface and wherein the main surface presents localized sites that are made sensitive to fluorescence detection by a transparent layer having optical thickness (2k+1)&lgr;/4 where k is a positive or zero integer and where &lgr; designates a wavelength lying between a wavelength &lgr;0 at which fluorescence is excited and a wavelength &lgr;1 at which fluorescence is emitted. The biochip can be manufactured by depositing a transparent layer of thickness m&lgr;′/2 on a substrate and by making studs or wells of thickness (2k+1)&lgr;/4 in said layer to form said sensitive sites.Type: ApplicationFiled: July 21, 2004Publication date: December 9, 2004Inventors: Jean Rene Martin, Michel Garrigues, Marlene Bras, Francois Bessueille, Eliane Souteyrand, Michel Cabrera, Jean-Pierre Cloarec, Jean-Paul Chauvet, Dorothee Chauvet, Jean-Michel Chauvet, Christophe Chauvet
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Publication number: 20040209269Abstract: The invention relates to: a method of functionalising solid supports; the functionalised solid supports thus obtained; and the use thereof, in particular for the immobilisation of biological molecules, such as nucleic acids, polypeptides, lipids, carbohydrates and hormones.Type: ApplicationFiled: June 2, 2004Publication date: October 21, 2004Inventors: Vincent Dugas, Yves Chevalier, Eliane Souteyrand
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Patent number: 6803229Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essentType: GrantFiled: March 25, 2003Date of Patent: October 12, 2004Assignees: L'Ecole Centrale de Lyon, Le Centre National de la Recherche ScientifiqueInventors: Jean-Rene Martin, Eliane Souteyrand, Marcus Francois Lawrence, Susan Rosalie Mikkelsen
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Publication number: 20030143625Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essentType: ApplicationFiled: March 25, 2003Publication date: July 31, 2003Applicant: L'ECOLE CENTRALE DE LYONInventors: Jean-Rene Martin, Eliane Souteyrand, Marcus Francois Lawrence, Susan Rosalie Mikkelsen
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Publication number: 20030138796Abstract: The invention concerns the use, for synthesising and immobilising nucleic acids, of a solid support modified by an organised self-assembled monolayer of one or several organosilicon compounds. The invention also concerns methods for synthesising and immobilising nucleic acids on such a silanized solid support, and DNA chips obtained by said methods.Type: ApplicationFiled: November 12, 2002Publication date: July 24, 2003Inventors: Bernard Benneteau, Jamal Bousbaa, Franck Choplin, Eliane Souteyrand, Jean-Rene Martin, Jean-Pierre Cloarec
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Patent number: 6562577Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essentType: GrantFiled: January 16, 2002Date of Patent: May 13, 2003Assignees: L'Ecole Centrale de Lyon, Le Centre National de la Recherche ScientifiqueInventors: Jean-Rene Martin, Eliane Souteyrand, Marcus Francois Lawrence, Susan Rosalie Mikkelsen
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Patent number: 6475728Abstract: An apparatus and method for identifying and/or quantifying a charged biological substance in a conductive liquid medium.Type: GrantFiled: March 31, 2000Date of Patent: November 5, 2002Assignees: Ecole Centrale de Lyon, Centre National de la Recherche Scientifique (C.N.R.S)Inventors: Jean-René Martin, Eliane Souteyrand