Patents by Inventor ELIAS BECHARA

ELIAS BECHARA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTISENSE OLIGONUCLEOTIDES AND USES THEREOF
    Publication number: 20230414649
    Abstract: Disclosed herein are novel compounds comprising antisense oligonucleotides that regulate the splicing of NUMB. In particular, an antisense oligonucleotide for reducing inclusion of NUMB exon 9 in a population of mature NUMB transcripts is provided. The antisense oligonucleotide comprises a sequence of at least 7 nucleotides that is complementary to a target region within exon 9 of a NUMB transcript. Pharmaceutical compositions comprising the antisense oligonucleotide and methods of treating a proliferative disease using the compounds or compositions of the invention are also described.
    Type: Application
    Filed: April 18, 2023
    Publication date: December 28, 2023
    Applicants: FUNDACIÓ CENTRE DE REGULACIÓ GENÒMMICA, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, FUNDACIÓN DEL SECTOR PUBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONSE ONCO
    Inventors: Jordi HERNÁNDEZ RIBERA, Juan Alberto VALCÁRCEL JUÁREZ, ELIAS BECHARA, Manuel SERRANO MARUGÁN, Miguel ROVIRA DEL OLMO, Pablo José FERNÁNDEZ MARCOS
  • Antisense oligonucleotides and uses thereof
    Patent number: 11672816
    Abstract: Disclosed herein are novel compounds comprising antisense oligonucleotides that regulate the splicing of NUMB. In particular, an antisense oligonucleotide for reducing inclusion of NUMB exon 9 in a population of mature NUMB transcripts is provided. The antisense oligonucleotide comprises a sequence of at least 7 nucleotides that is complementary to a target region within exon 9 of a NUMB transcript. Pharmaceutical compositions comprising the antisense oligonucleotide and methods of treating a proliferative disease using the compounds or compositions of the invention are also described.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: June 13, 2023
    Assignees: INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, FUNDACIÓ CENTRE DE REGULACIÓ GENÒMICA, FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACION
    Inventors: Jordi Hernández Ribera, Juan Alberto Valcárcel Juárez, Elias Bechara, Manuel Serrano Marugán, Miguel Rovira Del Olmo, Pablo José Fernández Marcos
  • ANTISENSE OLIGONUCLEOTIDES AND USES THEREOF
    Publication number: 20220079969
    Abstract: Disclosed herein are novel compounds comprising antisense oligonucleotides that regulate the splicing of NUMB. In particular, an antisense oligonucleotide for reducing inclusion of NUMB exon 9 in a population of mature NUMB transcripts is provided. The antisense oligonucleotide comprises a sequence of at least 7 nucleotides that is complementary to a target region within exon 9 of a NUMB transcript. Pharmaceutical compositions comprising the antisense oligonucleotide and methods of treating a proliferative disease using the compounds or compositions of the invention are also described.
    Type: Application
    Filed: March 19, 2019
    Publication date: March 17, 2022
    Inventors: JORDI HERNÁNDEZ RIBERA, JUAN ALBERTO VALCÁRCEL JUÁREZ, ELIAS BECHARA, MANUEL SERRANO MARUGÁN, MIGUEL ROVIRA DEL OLMO, PABLO JOSÉ FERNÁNDEZ MARCOS