Patents by Inventor Elias Shezen
Elias Shezen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230256028Abstract: A method of treating a pulmonary disorder or injury in a subject in need thereof is disclosed. The method comprising administering to the subject non-syngeneic pulmonary tissue cells in suspension comprising an effective amount of hematopoietic precursor cells (HPCs) or supplemented with HPCs, wherein the effective amount is a sufficient amount to achieve tolerance to the pulmonary tissue cells in the absence of chronic immunosuppressive regimen. A method of inducing donor specific tolerance in a subject in need of a pulmonary cell or tissue transplantation is also disclosed.Type: ApplicationFiled: April 21, 2023Publication date: August 17, 2023Applicant: Yeda Research and Development Co. Ltd.Inventors: Yair REISNER, Carmit HILLEL-KARNIEL, Chava ROSEN, Esther BACHAR-LUSTIG, Elias SHEZEN
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Publication number: 20200289582Abstract: A method of conditioning a subject in need of transplantation of progenitor cells in suspension of a tissue of interest is disclosed. The method comprising: (a) administering to a subject a therapeutically effective amount of an agent capable of inducing damage to the tissue of interest, wherein the damage results in proliferation of resident stem cells in the tissue; and subsequently (b) subjecting the subject to an agent which ablates the resident stem cells in the tissue. A method of transplanting progenitor cells in suspension of a tissue of interest to a subject in need thereof is also disclosed.Type: ApplicationFiled: May 28, 2020Publication date: September 17, 2020Applicant: Yeda Research and Development Co. Ltd.Inventors: Yair REISNER, Chava ROSEN, Elias SHEZEN, Irit MILMAN KRENTSIS
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Patent number: 10668109Abstract: A method of conditioning a subject in need of transplantation of progenitor cells in suspension of a tissue of interest is disclosed. The method comprising: (a) administering to a subject a therapeutically effective amount of an agent capable of inducing damage to the tissue of interest, wherein the damage results in proliferation of resident stem cells in the tissue; and subsequently (b) subjecting the subject to an agent which ablates the resident stem cells in the tissue. A method of transplanting progenitor cells in suspension of a tissue of interest to a subject in need thereof is also disclosed.Type: GrantFiled: June 16, 2016Date of Patent: June 2, 2020Assignee: Yeda Research and Development Co. Ltd.Inventors: Yair Reisner, Chava Rosen, Elias Shezen, Irit Milman Krentsis
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Publication number: 20190091266Abstract: A method of treating a pulmonary disorder or injury in a subject in need thereof is disclosed. The method comprising administering to the subject non-syngeneic pulmonary tissue cells in suspension comprising an effective amount of hematopoietic precursor cells (HPCs) or supplemented with HPCs, wherein the effective amount is a sufficient amount to achieve tolerance to the pulmonary tissue cells in the absence of chronic immunosuppressive regimen. A method of inducing donor specific tolerance in a subject in need of a pulmonary cell or tissue transplantation is also disclosed.Type: ApplicationFiled: November 22, 2018Publication date: March 28, 2019Applicant: Yeda Research and Development Co. Ltd.Inventors: Yair Reisner, Carmit Hillel-Karniel, Chava Rosen, Esther Bachar-Lustig, Elias Shezen
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Publication number: 20180169152Abstract: A method of conditioning a subject in need of transplantation of progenitor cells in suspension of a tissue of interest is disclosed. The method comprising: (a) administering to a subject a therapeutically effective amount of an agent capable of inducing damage to the tissue of interest, wherein the damage results in proliferation of resident stem cells in the tissue; and subsequently (b) subjecting the subject to an agent which ablates the resident stem cells in the tissue. A method of transplanting progenitor cells in suspension of a tissue of interest to a subject in need thereof is also disclosed.Type: ApplicationFiled: June 16, 2016Publication date: June 21, 2018Inventors: Yair REISNER, Chava ROSEN, Elias SHEZEN, Irit MILMAN KRENTSIS
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Patent number: 9833482Abstract: A pharmaceutical composition comprising as an active ingredient an isolated population of cell suspension from a mammalian fetal pulmonary tissue is disclosed. The fetal pulmonary tissue is at a developmental stage corresponding to that of a human pulmonary organ/tissue at a gestational stage selected from a range of about 20 to about 22 weeks of gestation. Methods of using the pharmaceutical composition are also disclosed.Type: GrantFiled: December 6, 2012Date of Patent: December 5, 2017Assignee: Yeda Research and Development Co. Ltd.Inventors: Yair Reisner, Elias Shezen, Chava Rosen
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Publication number: 20150190546Abstract: A method of treating a renal, hepatic or enzyme-deficiency disorder in a subject in need thereof is disclosed. The method is effected by transplanting into the subject tissue derived from a human or porcine, kidney or liver, the kidney or liver being at a selected gestational stage.Type: ApplicationFiled: February 9, 2015Publication date: July 9, 2015Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Yair REISNER, Benjamin DEKEL, Smadar EVENTOV-FRIEDMAN, Helena KATCHMAN, Elias SHEZEN, Anna ARONOVICH, Dalit TCHORSH-YUTSIS
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Publication number: 20150174294Abstract: A method of providing a pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue function to a mammalian subject is provided. The method comprises transplanting into the subject a developing mammalian pancreatic, lymphoid/hematopietic or pulmonary organ/tissue graft, respectively, thereby generating a functional pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue, respectively, for providing the pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue function, respectively, to the subject.Type: ApplicationFiled: March 9, 2015Publication date: June 25, 2015Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Yair REISNER, Benjamin DEKEL, Smadar EVENTOV-FRIEDMAN, Helena KATCHMAN, Elias SHEZEN, Anna ARONOVICH, Dalit TCHORSH-YUTSIS
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Patent number: 8974779Abstract: A method of providing a pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue function to a mammalian subject is provided. The method comprises transplanting into the subject a developing mammalian pancreatic, lymphoid/hematopietic or pulmonary organ/tissue graft, respectively, thereby generating a functional pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue, respectively, for providing the pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue function, respectively, to the subject.Type: GrantFiled: October 2, 2005Date of Patent: March 10, 2015Assignee: Yeda Research and Development Co. Ltd.Inventors: Yair Reisner, Benjamin Dekel, Smadar Eventov-Friedman, Helena Katchman, Elias Shezen, Anna Aronovich, Dalit Tchorsh
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Patent number: 8951572Abstract: A method of treating a renal, hepatic or enzyme-deficiency disorder in a subject in need thereof is disclosed. The method is effected by transplanting into the subject tissue derived from a human or porcine, kidney or liver, the kidney or liver being at a selected gestational stage.Type: GrantFiled: May 11, 2010Date of Patent: February 10, 2015Assignee: Yeda Research and Development Co. Ltd.Inventors: Yair Reisner, Benjamin Dekel, Smadar Eventov-Friedman, Helena Katchman, Elias Shezen, Anna Aronovich, Dalit Tchorsh
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Publication number: 20150010512Abstract: A method of providing a pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue function to a mammalian subject is provided. The method comprises transplanting into the subject a developing mammalian pancreatic, lymphoid/hematopietic or pulmonary organ/tissue graft, respectively, thereby generating a functional pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue, respectively, for providing the pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue function, respectively, to the subject.Type: ApplicationFiled: October 2, 2005Publication date: January 8, 2015Applicant: Yeda Research And Development Co. Ltd.Inventors: Yair Reisner, Benjamin Dekel, Smadar Eventov-Friedman, Helena Katchman, Elias Shezen, Anna Aronovich, Dalit Tchorsh
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Publication number: 20140356335Abstract: A pharmaceutical composition comprising as an active ingredient an isolated population of cell suspension from a mammalian fetal pulmonary tissue is disclosed. The fetal pulmonary tissue is at a developmental stage corresponding to that of a human pulmonary organ/tissue at a gestational stage selected from a range of about 20 to about 22 weeks of gestation. Methods of using the pharmaceutical composition are also disclosed.Type: ApplicationFiled: December 6, 2012Publication date: December 4, 2014Inventors: Yair Reisner, Elias Shezen, Chava Rosen
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Publication number: 20100221270Abstract: A method of treating a renal, hepatic or enzyme-deficiency disorder in a subject in need thereof is disclosed. The method is effected by transplanting into the subject tissue derived from a human or porcine, kidney or liver, the kidney or liver being at a selected gestational stage.Type: ApplicationFiled: May 11, 2010Publication date: September 2, 2010Applicant: Yeda Research And Development Co. Ltd.Inventors: Yair REISNER, Benjamin Dekel, Smadar Eventov-Friedman, Helena Katchman, Elias Shezen, Anna Aronovich, Dalit Tchorsh
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Patent number: 7780993Abstract: A method of treating a renal, hepatic or enzyme-deficiency disorder in a subject in need thereof is disclosed. The method is effected by transplanting into the subject tissue derived from a human or porcine, kidney or liver, the kidney or liver being at a selected gestational stage.Type: GrantFiled: January 19, 2005Date of Patent: August 24, 2010Assignee: Yeda Research and Development Co. Ltd.Inventors: Yair Reisner, Benjamin Dekel, Smadar Eventov-Friedman, Helena Katchman, Elias Shezen, Anna Aronovich, Dalit Tchorsh
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Publication number: 20100021433Abstract: A method of providing a pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue function to a mammalian subject is provided. The method comprises transplanting into the subject a developing mammalian pancreatic, lymphoid/hematopietic or pulmonary organ/tissue graft, respectively, thereby generating a functional pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue, respectively, for providing the pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue function, respectively, to the subject.Type: ApplicationFiled: October 2, 2005Publication date: January 28, 2010Applicant: Yeda Research And Development Co. Ltd.Inventors: Yair Reisner, Benjamin Dekel, Smadar Eventov-Friedman, Helena Katchman, Elias Shezen, Anna Aronovich, Dalit Tchorsh
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Publication number: 20090324607Abstract: A method of treating a renal, hepatic or enzyme-deficiency disorder in a subject in need thereof is disclosed. The method is effected by transplanting into the subject tissue derived from a human or porcine, kidney or liver, the kidney or liver being at a selected gestational stage.Type: ApplicationFiled: January 19, 2006Publication date: December 31, 2009Applicant: Yeda Research And Development Co. Ltd.Inventors: Yair Reisner, Benjamin Dekel, Smadar Eventov-Friedman, Helena Katchman, Elias Shezen, Anna Aronovich, Dalit Tchorsh
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Publication number: 20050226854Abstract: A method of treating a renal, hepatic or enzyme-deficiency disorder in a subject in need thereof is disclosed. The method is effected by transplanting into the subject tissue derived from a human or porcine, kidney or liver, the kidney or liver being at a selected gestational stage.Type: ApplicationFiled: January 19, 2005Publication date: October 13, 2005Inventors: Yair Reisner, Benjamin Dekel, Smadar Eventov-Friedman, Helena Katchman, Elias Shezen, Anna Aronovich, Dalit Tchorsh