Patents by Inventor Elias Zerhouni
Elias Zerhouni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240059798Abstract: Disclosed are antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural features. Also disclosed are polynucleotides and vectors encoding such polypeptide complexes; cells, pharmaceutical compositions, and kits containing such polypeptide complexes; and methods of using such polypeptide complexes.Type: ApplicationFiled: December 21, 2022Publication date: February 22, 2024Inventors: LING XU, LAN WU, EDWARD SEUNG, ZHI-YONG YANG, GARY J. NABEL, ELIAS ZERHOUNI, RONNIE R. WEI, HAO CHEN, MARK GRECI, NICHOLAS JONES
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Publication number: 20240034808Abstract: Disclosed are antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural features. Also disclosed are polynucleotides and vectors encoding such polypeptide complexes; cells, pharmaceutical compositions, and kits containing such polypeptide complexes; and methods of using such polypeptide complexes.Type: ApplicationFiled: December 16, 2022Publication date: February 1, 2024Inventors: HEATHER DAWN KAMP, EDWARD SEUNG, ZHI-YONG YANG, GARY J. NABEL, RONNIE R. WEI, ELIAS ZERHOUNI
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Patent number: 8277391Abstract: In order to later identify the location of a biopsy or surgery, various means and methods for permanently and non-surgically marking selected tissue in the human body are used. Later visualization of the markers is readily accomplished using state-of-the-art imaging systems.Type: GrantFiled: August 7, 2002Date of Patent: October 2, 2012Assignee: Devicor Medical Products, Inc.Inventors: Seth A. Foerster, Fred H. Burbank, Mark A. Ritchart, Elias A. Zerhouni
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Patent number: 7044957Abstract: In order to later identify the location of a biopsy or surgery, various means and methods for permanently and non-surgically marking selected tissue in the human body are used. Later visualization of the markers is readily accomplished using state-of-the-art imaging systems.Type: GrantFiled: February 2, 2001Date of Patent: May 16, 2006Assignee: Ethicon Endo-Surgery, Inc.Inventors: Seth A. Foerster, Fred H. Burbank, Mark A. Ritchart, Elias A. Zerhouni
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Publication number: 20050165305Abstract: In order to later identify the location of a biopsy or surgery, various means and methods for permanently and non-surgically marking selected tissue in the human body are used. Later visualization of the markers is readily accomplished using state-of-the-art imaging systems.Type: ApplicationFiled: December 12, 2003Publication date: July 28, 2005Inventors: Seth Foerster, Fred Burbank, Mark Ritchart, Elias Zerhouni
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Patent number: 6628980Abstract: The apparatus, systems and methods of the present invention provide for MRI sleeves, probes, and combinations thereof adapted for insertion into a subject, in order to internally image regions of the subject.Type: GrantFiled: March 26, 2001Date of Patent: September 30, 2003Assignee: Surgi-Vision, Inc.Inventors: Ergin Atalar, Paul A. Bottomley, Parag Karmarkar, Albert C. Lardo, Elias Zerhouni
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Publication number: 20020193815Abstract: In order to later identify the location of a biopsy or surgery, various means and methods for permanently and non-surgically marking selected tissue in the human body are used. Later visualization of the markers is readily accomplished using state-of-the-art imaging systems.Type: ApplicationFiled: August 7, 2002Publication date: December 19, 2002Inventors: Seth A. Foerster, Fred H. Burbank, Mark A. Ritchart, Elias A. Zerhouni
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Publication number: 20020045816Abstract: The apparatus, systems and methods of the present invention provide for MRI sleeves, probes, and combinations thereof adapted for insertion into a subject, in order to internally image regions of the subject.Type: ApplicationFiled: March 26, 2001Publication date: April 18, 2002Inventors: Ergin Atalar, Paul A. Bottomley, Parag Karmarkar, Albert C. Lardo, Elias Zerhouni
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Publication number: 20010034528Abstract: In order to later identify the location of a biopsy or surgery, various means and methods for permanently and non-surgically marking selected tissue in the human body are used. Later visualization of the markers is readily accomplished using state-of-the-art imaging systems.Type: ApplicationFiled: February 2, 2001Publication date: October 25, 2001Inventors: Seth A. Foerster, Fred H. Burbank, Mark A. Ritchart, Elias A. Zerhouni
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Patent number: 6228055Abstract: Implantable devices are disclosed for marking the location of a biopsy or surgery for the purpose of identification. The devices are remotely delivered, preferably percutaneously. Visualization of the markers is readily accomplished using various state of the art imaging systems. Using the inventive systems, it is possible to permanently mark the location or margins of a lesion or other tissue site, prior to removing or sampling same. The markers function to provide evidence of the location of the lesion after the procedure is completed, for reference during future examinations or procedures.Type: GrantFiled: May 19, 1997Date of Patent: May 8, 2001Assignee: Ethicon Endo-Surgery, Inc.Inventors: Seth A. Foerster, Fred H. Burbank, Mark A. Ritchart, Elias A. Zerhouni
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Patent number: 5980469Abstract: A method and device for the automated biopsy and collection of soft tissue having a piercing needle with a receiving port to trap tissue prior to cutting. A motor drive directs and positions the tissue receiving port at a lesion site in arbitrary positions about and along the longitudinal axis of the device. A cutter advances into the receiving chamber and severs tissue which has prolapsed into the receiving port. The severed tissue is then removed from the receiving port without removing the piercing needle receiving port from the lesion site, thus allowing for the accurate, rapid removal of an arbitrary number of core samples with only one insertion. A tissue sample cassette provides storage for the samples as well as a means for coding and decoding the location from which the samples were obtained. Together, these features allow for more accurate and complete sampling of large lesions, for the complete removal of small lesions or removal of other tissue for a variety of reasons.Type: GrantFiled: January 9, 1998Date of Patent: November 9, 1999Assignee: Ethicon Endo-Surgery, Inc.Inventors: Fred H. Burbank, Thomas J. Fogarty, Wayne E. Manska, Mark A. Ritchart, Timothy J. Ryan, Elias A. Zerhouni
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Patent number: 5928164Abstract: A method and device for the automated biopsy and collection of soft tissue having a piercing needle with a receiving port to trap tissue prior to cutting. A motor drive directs and positions the tissue receiving port at a lesion site in arbitrary positions about and along the longitudinal axis of the device. A cutter advances into the receiving chamber and severs tissue which has prolapsed into the receiving port. The severed tissue is then removed from the receiving port without removing the piercing needle receiving port from the lesion site, thus allowing for the accurate, rapid removal of an arbitrary number of core samples with only one insertion. A tissue sample cassette provides storage for the samples as well as a means for coding and decoding the location from which the samples were obtained. Together, these features allow for more accurate and complete sampling of large lesions, for the complete removal of small lesions or removal of other tissue for a variety of reasons.Type: GrantFiled: January 9, 1998Date of Patent: July 27, 1999Assignee: Ethicon Endo-Surgery, Inc.Inventors: Fred H. Burbank, Thomas J. Fogarty, Wayne E. Manska, Mark A. Ritchart, Timothy J. Ryan, Elias A. Zerhouni
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Patent number: 5775333Abstract: A method and device for the automated biopsy and collection of soft tissue having a piercing needle with a receiving port to trap tissue prior to cutting. A motor drive directs and positions the tissue receiving port at a lesion site in arbitrary positions about and along the longitudinal axis of the device. A cutter advances into the receiving chamber and severs tissue which has prolapsed into the receiving port. The severed tissue is then removed from the receiving port without removing the piercing needle receiving port from the lesion site, thus allowing for the accurate, rapid removal of an arbitrary number of core samples with only one insertion. A tissue sample cassette provides storage for the samples as well as a means for coding and decoding the location from which the samples were obtained. Together, these features allow for more accurate and complete sampling of large lesions, for the complete removal of small lesions or removal of other tissue for a variety of reasons.Type: GrantFiled: May 13, 1996Date of Patent: July 7, 1998Assignee: Ethicon Endo-Surgery, Inc.Inventors: Fred H. Burbank, Thomas J. Fogarty, Wayne E. Manska, Mark A. Ritchart, Timothy J. Ryan, Elias A. Zerhouni
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Patent number: 5699801Abstract: The invention provides a method for magnetic resonance imaging and spectroscopic analysis of the interior of a specimen which includes positioning the specimen within a main magnetic field, introducing an invasive probe having an elongated receiver coil into or adjacent to the specimen with the coil having at least one pair of elongated electrical conductors, preferably, generally parallel to each other disposed within a dielectric material and having a pair of ends electrically connected to each other. RF pulses are provided to the region of interest to excite magnetic resonance signals, gradient magnetic pulses are applied to the region of interest with the receiver coil receiving magnetic resonance signals and emitting responsive output signals which may be processed by a computer to provide image information for display in a desired manner.Type: GrantFiled: June 1, 1995Date of Patent: December 23, 1997Assignee: The Johns Hopkins UniversityInventors: Ergin Atalar, Paul A. Bottomley, Elias A. Zerhouni
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Patent number: 5526822Abstract: A method and device for the automated biopsy and collection of soft tissue having a piercing needle with a receiving port to trap tissue prior to cutting. A motor drive directs and positions the tissue receiving port at a lesion site in arbitrary positions about and along the longitudinal axis of the device. A cutter advances into the receiving chamber and severs tissue which has prolapsed into the receiving port. The severed tissue is then removed from the receiving port without removing the piercing needle receiving port from the lesion site, thus allowing for the accurate, rapid removal of an arbitrary number of core samples with only one insertion. A tissue sample cassette provides storage for the samples as well as a means for coding and decoding the location from which the samples were obtained. Together, these features allow for more accurate and complete sampling of large lesions, for the complete removal of small lesions or removal of other tissue for a variety of reasons.Type: GrantFiled: March 24, 1994Date of Patent: June 18, 1996Assignee: Biopsys Medical, Inc.Inventors: Fred H. Burbank, Thomas J. Fogarty, Wayne E. Manska, Mark A. Ritchart, Timothy J. Ryan, Elias A. Zerhouni
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Patent number: 4953554Abstract: A magnetic resonance imaging (MRI) method imposes void planes on tissue to be imaged, which may form a grid pattern of lines which, when later imaged, produces a reference void in the image. This is especially useful in studies of the heart where the contraction and relaxation of the heart can thus be measured. Also for static tissue the method is useful for radiation therapy port planning. The grid reference or void planes are formed by a simple use of an RF pulse in conjunction with the use of a slice select gradient which provides sufficient power so that those protons in the grid are saturated so that in the later imaging step there will be significant spin echo signal difference between the grid imposed areas and the remaining regions of the tissue.Type: GrantFiled: March 4, 1988Date of Patent: September 4, 1990Assignees: Resonex, Inc., Johns Hopkins UniversityInventors: Elias Zerhouni, David M. Parish
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Patent number: 4646334Abstract: Disclosed is a test phantom for evaluating a computed tomographic scan of nodules in a lung of a human or non-human animal comprising a device which simulates a 15 to 40 mm thick transverse section of said animal the tissue simulating portions of said device are constructed of materials having radiographic densities substantially identical to those of the corresponding tissue in said simulated transverse section of said animal and contain voids therein which simulate, in size and shape, the lung cavities in said transverse section. At least one of the voids has positioned therein a test reference device constructed of a material of predetermined radiographic density which simulates a lung nodule.Type: GrantFiled: January 14, 1986Date of Patent: February 24, 1987Inventor: Elias A. Zerhouni