Abstract: A non-invasive device for detecting Alzheimer's Disease-associated pathologies, comprising a fundus camera comprising a spectral reflectance imaging unit that includes a broadband light source and a light sensor and a lens assembly to focus light from the broadband light source onto a fundus of an eye, and one or more processors to detect reflected and/or backscattered light from the eye, illuminated by the broadband light source, using the light sensor for determining spectral reflectance information, generate a plurality of spectral reflectance maps comprising counts of reflected and/or backscattered light at a different wavelength or a different range of wavelengths, assign a weight to each of the spectral reflectance maps, and determine one or more regions of interest from the weighted spectral reflectance maps as being a potential Alzheimer's Disease-associated pathology based on a detection of one or more biomarkers indicative of Tauopathy.

Abstract: The present disclosure provides systems and methods for diagnosing disease. In some aspects, an imaging system is provided that includes a light source configured to illuminate a retina of the eye with light, one or more imaging devices configured to receive light returned from the retina to generate one or more spatial-spectral images of the retina, and a computing device configured to receive the one or more spatial-spectral images of the retina, evaluate the one or more spatial-spectral images, and identify one or more biomarkers indicative of a neurogenerative pathology.

Abstract: A non-invasive ocular light-based detection device for detecting Alzheimer's Disease (AD)-associated pathologies in the retina of the eye. The device uses two imaging modalities where one imaging modality guides the particular regions to be interrogated by the second imaging modality. A hyperspectral reflectance imaging unit detects light reflected and/or backscattered off of the retina from a broadband light source, which is used to determine one or more regions of interest. A Raman spectroscopy unit detects light that is re-emitted by the retina by Raman scattering phenomenon from a laser that is targeted onto a region of interest that is determined from hyperspectral reflectance information. The detected information from the hyperspectral reflectance imaging unit and the Raman spectroscopy unit are used to determine the presence of the one or more AD-associated pathologies. The detection device allows for the identification of at-risk populations, diagnosis, and tracking of patient response to treatments.