Patents by Inventor Elie Saikali

Elie Saikali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of N-(amino-4, 6-dihalo-pyrimidine) formamides
    Patent number: 6716981
    Abstract: A process for the preparation of a 2,5-diamino-4,6-dihalopyrimidine of the formula: in which X is a halogen atom, comprising reacting 2,5-diamino-4,6-dihydroxypyrimidine or its salt of the formula: with a phosphorus oxyhalide and a quaternary ammonium halide or an amine in a halogenated hydrocarbon as a solvent.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: April 6, 2004
    Assignee: Lonza AG
    Inventors: Elie Saikali, Walter Brieden
  • Method for producing 4-[2',5'-diamino-6'-halopyrimidine-4'-yl)amino]- cyclopent-2-enylmethanols
    Patent number: 6433170
    Abstract: The invention relates to a novel method for producing 4-[(2′,5′-diamino-6′-halopyrimidine-4′-yl)amino]-cyclopent-2-enylmethanols of general formula (I), wherein X represents a halogen atom. According to the inventive method amino-4,6-halopyrimidine of general formula (II), wherein X has the aforementioned meaning, is reacted with a 4-aminocyclopent-2-enylmethanol of formula (III) or with a salt thereof in the presence of a base in a polar protic solvent.
    Type: Grant
    Filed: June 17, 2001
    Date of Patent: August 13, 2002
    Assignee: Lonza Group
    Inventors: Walter Brieden, Elie Saikali
  • Process for the preparation of N-(amino-4, 6-dihalo-pyrimidine) formamides
    Publication number: 20010031868
    Abstract: A novel process is described for the preparation of N-(amino-4,6-dihalopyrimidine)formamides of the formula 1
    Type: Application
    Filed: May 31, 2001
    Publication date: October 18, 2001
    Inventors: Elie Saikali, Walter Brieden
  • Process for the preparation of N-(amino-4,6-dihalo-pyrimidine) formamides
    Patent number: 6271376
    Abstract: A process for the preparation of N-(amino-4,6-dihalopyrimidine)formamides of the formula: in which X is a halogen atom, starting from 2,5-diamino-4,6-dihalopyrimidine of the formula: in which X has the meaning afore-mentioned, by reaction with formic acid.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: August 7, 2001
    Assignee: Lonza AG
    Inventors: Elie Saikali, Walter Brieden
  • 2 step process for preparing biologically active tropane derivatives and starting material therefore
    Patent number: 5342949
    Abstract: Preparation of biologically active tropane derivatives of novel configurations. The compounds are prepared by decomposing vinyldiazomethanes in the presence of pyrroles to provide a bicyclic ring containing the basic tropane ring system which is then reacted with an aryl Grignard reagent in the presence of a copper (I) or (II) salt to provide 3-aryl-tropane derivatives.
    Type: Grant
    Filed: November 17, 1992
    Date of Patent: August 30, 1994
    Assignee: Wake Forest University
    Inventors: Huw M. L. Davies, Elie Saikali, Steven R. Childers
  • Compounds for treatment of neurodegenerative diseases
    Patent number: 5288872
    Abstract: Novel tropane ring system compounds useful for treatment of neurological disorders and for synthetic starting materials for production of cocaine analogs.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: February 22, 1994
    Assignee: Wake Forest University
    Inventors: Huw M. L. Davies, Elie Saikali
  • Biologically active tropane derivatives
    Patent number: 5262428
    Abstract: Preparation of biologically active tropane derivatives of novel configurations. The compounds are prepared by decomposing vinyldiazomethanes in the presence of pyrroles to provide a bicyclic ring containing the basic tropane ring system which is then reacted with an aryl Grignard reagent in the presence of a copper (I) or (II) salt to provide 3-aryltropane derivatives.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: November 16, 1993
    Assignee: Wake Forest University
    Inventors: Huw M. L. Davies, Elie Saikali, Steven R. Childers