Patents by Inventor Eliezer Huberman
Eliezer Huberman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9511070Abstract: Methods, uses, medicaments, and unit doses for treating viral diseases are described herein. The methods, uses, medicaments, and unit doses include (a) substituted piperidine and piperazine carboxamides, or a pharmaceutically acceptable salt thereof and (b) one or more pharmaceutically acceptable carriers, excipients or diluents, or combinations thereof. Viral diseases include hepatitis C virus, HIV, BVDV, and Coronavirus infections.Type: GrantFiled: August 30, 2013Date of Patent: December 6, 2016Assignee: NovaDrug, LLCInventor: Eliezer Huberman
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Patent number: 9241930Abstract: Substituted perhydro pyrrolopyridines and methods for their use in the treatment of HIV infections, AIDS, and AIDS-related diseases, and in the treatment of BVDV infections are described herein. Also, pharmaceutical compositions comprising the substituted perhydro pyrrolopyridines are useful for the treatment of HIV infections, AIDS, and AIDS-related diseases. The compositions include one or more carriers, diluents, or excipients, or a combination thereof.Type: GrantFiled: August 23, 2012Date of Patent: January 26, 2016Assignee: NovaDrug, LLCInventor: Eliezer Huberman
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Publication number: 20150238489Abstract: Methods, uses, medicaments, and unit doses for treating viral diseases are described herein. The methods, uses, medicaments, and unit doses include (a) substituted piperidine and piperazine carboxamides, or a pharmaceutically acceptable salt thereof and (b) one or more pharmaceutically acceptable carriers, excipients or diluents, or combinations thereof. Viral diseases include hepatitis C virus, HIV, BVDV, and Coronavirus infections.Type: ApplicationFiled: August 30, 2013Publication date: August 27, 2015Inventor: Eliezer Huberman
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Patent number: 9056099Abstract: Substituted perhydro pyrrolopyridines and methods for their use in the treatment of viral diseases including hepatitis C viral infections are described herein.Type: GrantFiled: February 25, 2011Date of Patent: June 16, 2015Assignee: NovaDrug, LLCInventor: Eliezer Huberman
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Publication number: 20140249178Abstract: Substituted perhydro pyrrolopyridines and methods for their use in the treatment of HIV infections, AIDS, and AIDS-related diseases, and in the treatment of BVDV infections are described herein. Also, pharmaceutical compositions comprising the substituted perhydro pyrrolopyridines are useful for the treatment of HIV infections, AIDS, and AIDS-related diseases. The compositions include one or more carriers, diluents, or excipients, or a combination thereof.Type: ApplicationFiled: August 23, 2012Publication date: September 4, 2014Applicant: NOVADRUG, LLCInventor: Eliezer Huberman
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Patent number: 8815878Abstract: Substituted spiro hemiaminals and methods for their use in the treatment of viral diseases, including hepatitis C viral infections, are described herein.Type: GrantFiled: July 27, 2011Date of Patent: August 26, 2014Assignee: NovaDrug, LLCInventor: Eliezer Huberman
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Publication number: 20130129696Abstract: Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals is provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease.Type: ApplicationFiled: October 26, 2012Publication date: May 23, 2013Inventors: Eliezer Huberman, Yong Zhao
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Publication number: 20130059881Abstract: Substituted perhydro pyrrolopyridines and methods for their use in the treatment of viral diseases including hepatitis C viral infections are described herein.Type: ApplicationFiled: February 25, 2011Publication date: March 7, 2013Applicant: NOVADRUG, LLCInventor: Eliezer Huberman
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Publication number: 20110070644Abstract: Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals is provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease.Type: ApplicationFiled: November 24, 2010Publication date: March 24, 2011Inventors: Eliezer Huberman, Yong Zhao
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Publication number: 20080038238Abstract: Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals is provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof. The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease.Type: ApplicationFiled: August 6, 2007Publication date: February 14, 2008Inventors: Eliezer Huberman, Yong Zhao
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Patent number: 7183106Abstract: The present invention relates to a nucleic acid sequence and its corresponding protein sequence useful as a dominant selectable marker in eukaryotes. More specifically the invention relates to a nucleic acid encoding a bacterial IMPDH gene that has been engineered into a eukaryotic expression vectors, thereby permitting bacterial IMPDH expression in mammalian cells. Bacterial IMPDH expression confers resistance to MPA which can be used as dominant selectable marker in eukaryotes including mammals. The invention also relates to expression vectors and cells that express the bacterial IMPDH gene as well as gene therapies and protein synthesis.Type: GrantFiled: May 28, 2004Date of Patent: February 27, 2007Assignee: The United States of America as represented by the United States Department of EnergyInventors: Eliezer Huberman, Mekhine J. Baccam
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Publication number: 20050260158Abstract: Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals are provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof. The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease, including disorders or diseases associated with aberrant function or presence (i.e., level) of pancreatic islet ?-cell-like macrophages.Type: ApplicationFiled: October 18, 2004Publication date: November 24, 2005Inventors: Eliezer Huberman, Yong Zhao
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Publication number: 20050003534Abstract: Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals are provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof. The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease including disorders or diseases associated with platelets.Type: ApplicationFiled: May 26, 2004Publication date: January 6, 2005Inventors: Eliezer Huberman, Yong Zhao
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Patent number: 6826488Abstract: The present invention relates to a data storage medium encoded with the structural coordinates of crystallized molecules and molecular complexes which comprise the active site binding pockets of bacterial IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes that comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets.Type: GrantFiled: March 23, 2000Date of Patent: November 30, 2004Assignee: The University of ChicagoInventors: Frank R. Collart, Eliezer Huberman, Andrezej Joachimiak, Rongguang Zhang, Edwin M. Westbrook
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Publication number: 20040136973Abstract: Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals is provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof. The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease.Type: ApplicationFiled: November 7, 2003Publication date: July 15, 2004Inventors: Eliezer Huberman, Yong Zhao
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Patent number: 6673623Abstract: The present invention relates generally to the use of lipogenins, proteins, e.g. human extra-cellular matrix protein 1 (ECM-1), human glia-derived nexin I alpha protein (NP-I), human tissue inhibitor of metalloproteinase-2 (TIMP-2) and human histone H2A (H2A) singly or in various combinations to control lipogenesis in a mammal.Type: GrantFiled: September 12, 2000Date of Patent: January 6, 2004Assignee: Novocure, Inc.Inventor: Eliezer Huberman
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Patent number: 6479628Abstract: Disclosed are purified and isolated DNA sequences encoding eukaryotic proteins possessing biological properties of inosine 5′-monophosphate dehydrogenase (“IMPDH”). Illustratively, mammalian (e.g., human) IMPDH-encoding DNA sequences are useful in transformation or transfection of host cells for the large scale recombinant production of the enzymatically active expression products and/or products (e.g., GMP) resulting from IMPDH catalyzed synthesis in cells. Vectors including IMPDH-encoding DNA sequences are useful in gene amplification procedures. Recombinant proteins and synthetic peptides provided by the invention are useful as immunological reagents and in the preparation of antibodies (including polyclonal and monoclonal antibodies) for quantitative detection of IMPDH.Type: GrantFiled: November 13, 2000Date of Patent: November 12, 2002Assignee: Arch Development CorporationInventors: Frank R. Collart, Eliezer Huberman
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Patent number: 6153398Abstract: This invention relates to methods to identify specific inhibitors of the purine nucleotide synthesis enzyme, IMP dehydrogenase (IMPDH). IMPDH is an essential enzyme found in all free-living organisms from humans to bacteria and is an important therapeutic target. The invention allows the identification of specific inhibitors of any IMPDH enzyme which can be expressed in a functional form in a recombinant host cell. A variety of eukaryotic or prokaryotic host systems commonly used for the expression of recombinant proteins are suitable for the practice of the invention. The methods are amenable to high throughput systems for the screening of inhibitors generated by combinatorial chemistry or other methods such as antisense molecule production. Utilization of exogenous guanosine as a control component of the methods allows for the identification of inhibitors specific for IMPDH rather than other causes of decreased cell proliferation.Type: GrantFiled: December 24, 1997Date of Patent: November 28, 2000Assignee: The University of ChicagoInventors: Frank R. Collart, Eliezer Huberman
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Patent number: 6147194Abstract: Disclosed are purified and isolated DNA sequences encoding eukaryotic proteins possessing biological properties of inosine 5'-monophosphate dehydrogenase ("IMPDH"). Illustratively, mammalian (e.g., human) IMPDH-encoding DNA sequences are useful in transformation or transfection of host cells for the large scale recombinant production of the enzymatically active expression products and/or products (e.g., GMP) resulting from IMPDH catalyzed synthesis in cells. Vectors including IMPDH-encoding DNA sequences are useful in gene amplification procedures. Recombinant proteins and synthetic peptides provided by the invention are useful as immunological reagents and in the preparation of antibodies (including polyclonal and monoclonal antibodies) for quantitative detection of IMPDH.Type: GrantFiled: September 8, 1997Date of Patent: November 14, 2000Assignee: Arch Development CorporationInventors: Frank R. Collart, Eliezer Huberman
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Patent number: 5665583Abstract: Disclosed are purified and isolated DNA sequences encoding eukaryotic proteins possessing biological properties of inosine 5'-monophosphate dehydrogenase ("IMPDH"). Illustratively, mammalian (e.g., human) IMPDH-encoding DNA sequences are useful in transformation or transfection of host cells for the large scale recombinant production of the enzymatically active expression products and/or products (e.g., GMP) resulting from IMPDH catalyzed synthesis in cells. Vectors including IMPDH-encoding DNA sequences are useful in gene amplification procedures. Recombinant proteins and synthetic peptides provided by the invention are useful as immunological reagents and in the preparation of antibodies (including polyclonal and monoclonal antibodies) for quantitative detection of IMPDH.Type: GrantFiled: August 12, 1988Date of Patent: September 9, 1997Inventors: Frank R. Collart, Eliezer Huberman