Patents by Inventor Eliezer Kedar
Eliezer Kedar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8673285Abstract: The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for modulating the immune response of a subject. Other aspects of the invention concern methods for modulating the immune response of a subject by the use of the conjugate, complexes comprising, the sphingoid-polyalkylamine conjugate in combination with a biologically active molecule capable of modulating an immune response of a subject, compositions comprising the conjugate as well as kits making use of said conjugate. A preferred conjugate according to the invention is N palmitoyl D-erythro sphingosyl 1 carbamoyl spermine.Type: GrantFiled: June 17, 2004Date of Patent: March 18, 2014Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Biolab Ltd.Inventors: Yechezkel Barenholz, Aviva Joseph, Eliezer Kedar
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Patent number: 7906122Abstract: The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for stimulating or enhancing an immune response of a subject to protect against Hepatitis B Virus (HBV) infection. Other aspects of the invention concern methods for stimulating or enhancing an immune response of a subject to protect against Hepatitis B Virus (HBV) infection, by the use of the sphingoid-polyalkylamine conjugate, complexes comprising the sphingoid-polyalkylamine conjugate and a biologically active molecule, the latter, having an effect of stimulating or enhancing an immune response of a subject against to protect Hepatitis B Virus (HBV) infection, as well as kits making use of said conjugates and complexes. A preferred conjugate according to the invention is N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine (CCS).Type: GrantFiled: February 2, 2006Date of Patent: March 15, 2011Assignees: Yissum Research Development Company of the Hebrew University of Jersusalem, Biolab Ltd., Nasvax Ltd.Inventors: Yechezkel Bareholz, Eliezer Kedar, Sarit Samira
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Publication number: 20070264273Abstract: The present application discloses methods for stimulating or enhancing an immune response of a subject to protect against an infection caused by an agent selected from Hepatitis B Virus (HBV), avian influenza virus, the bacterium Bacillus anthracis or the bacterium Streptococcus pneumoniae, the method comprising administering to said subject a combination of sphingoid-polyalkylamine conjugate and a biologically active molecule, the combination being effective to provide said stimulation or enhancement of the immune response. Also disclosed are vaccines comprising a combination of the sphingoid-polyalkylamine conjugate and a biologically active molecule for stimulating or enhancing an immune response of a subject to protect against an infection caused by such an agent. Preferred conjugates are N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine (C-1 CCS), N-palmitoyl D-erythro sphingosyl-3-carbamoyl spermine (C-3 CCS) and mixtures thereof. Also disclosed are uses of C-3 CCS for various applications.Type: ApplicationFiled: May 9, 2007Publication date: November 15, 2007Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem, BioLab Ltd., NasVax Ltd.Inventors: Yechezkel BARENHOLZ, Eliezer Kedar, Sarit Samira
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Publication number: 20060252717Abstract: The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for modulating the immune response of a subject. Other aspects of the invention concern methods for modulating the immune response of a subject by the use of the conjugate, complexes comprising, the sphingoid-polyalkylamine conjugate in combination with a biologically active molecule capable of modulating an immune response of a subject, compositions comprising the conjugate as well as kits making use of said conjugate. A preferred conjugate according to the invention is N palmitoyl D-erythro sphingosyl 1 carbamoyl spermine.Type: ApplicationFiled: June 17, 2004Publication date: November 9, 2006Applicant: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Yechezkel Barenholz, Aviva Joseph, Eliezer Kedar
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Publication number: 20060171956Abstract: The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for stimulating or enhancing an immune response of a subject to protect against Hepatitis B Virus (HBV) infection. Other aspects of the invention concern methods for stimulating or enhancing an immune response of a subject to protect against Hepatitis B Virus (HBV) infection, by the use of the sphingoid-polyalkylamine conjugate, complexes comprising the sphingoid-polyalkylamine conjugate and a biologically active molecule, the latter, having an effect of stimulating or enhancing an immune response of a subject against to protect Hepatitis B Virus (HBV) infection, as well as kits making use of said conjugates and complexes. A preferred conjugate according to the invention is N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine (CCS).Type: ApplicationFiled: February 2, 2006Publication date: August 3, 2006Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem, BIOLAB LTD., NasVax Ltd.Inventors: Yechezkel Bareholz, Eliezer Kedar, Sarit Samira
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Publication number: 20060029655Abstract: The present invention discloses a method for an efficient entrapment of active biological material in liposomes. The method is based on the steps of drying a suspension of liposome-forming lipids and then hydrating the dry composition obtained with an aqueous solution containing a biologically active material to be entrapped in high yield in the liposomes thus formed. The invention also concerns liposomal formulations produced by the method of the invention and their uses.Type: ApplicationFiled: June 25, 2002Publication date: February 9, 2006Applicant: Yissum Research Development Company Of The Hebrew University Of JerusalemInventors: Yechezkel Barenholz, Eliezer Kedar, Aviva Joseph
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Patent number: 6787132Abstract: A method of antitumor therapy is described in which administration of a chemotherapeutic drug, encapsulated in liposomes, is supplemented by administration of an immunostimulating cytokine. The cytokine is preferably also encapsulated in liposomes. In tumor models for lung and colon carcinomas, this method produced a significantly greater therapeutic effect, as evidenced by survival rate and tumor size, than a combination of the effects produced by the free or liposome-encapsulated components administered individually.Type: GrantFiled: August 3, 2000Date of Patent: September 7, 2004Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Hadasit Medical Research Services and Development, Ltd.Inventors: Alberto A. Gabizon, Eliezer Kedar, Yechezkel Barenholz
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Patent number: 5919480Abstract: Subunit influenza vaccines containing an influenza H/N antigen and a cytokine immunopotentiator, where at least one and preferably both are encapsulated in liposomes, are described. The vaccines stimulate a strong humoral and CTL response. Also described are methods of immunization using such vaccines.Type: GrantFiled: June 23, 1997Date of Patent: July 6, 1999Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Eliezer Kedar, Ilan Babai, Yechezkel Barenholz