Patents by Inventor Elijah H. Gold

Elijah H. Gold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carboxyalkyl dipeptides
    Patent number: 5348944
    Abstract: Compounds of the formula ##STR1## useful as antihypertensive agents are disclosed.
    Type: Grant
    Filed: April 4, 1988
    Date of Patent: September 20, 1994
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Bernard R. Neustadt, Elizabeth M. Smith
  • Fused benzazepines
    Patent number: 5302716
    Abstract: Disclosed are fused benzazepine compounds, pharmaceutical compositions including such compounds, methods of using such compounds, for example, in the treatment of psychoses and/or depression, and intermediates useful in the preparation of such compounds.
    Type: Grant
    Filed: November 6, 1990
    Date of Patent: April 12, 1994
    Assignee: Schering Corporation
    Inventors: Joel G. Berger, Wei K. Chang, Elijah H. Gold, John W. Clader
  • 1,2,4,5 tetrahydro benzazepine-3 compounds and antipsychotic use thereof
    Patent number: 4996202
    Abstract: Substituted 8-amino-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines useful in treating mental disorders and which have activities of prolonged duration are disclosed. Methods for preparing these compounds and methods for their use are also described.
    Type: Grant
    Filed: October 17, 1985
    Date of Patent: February 26, 1991
    Assignee: Schering Corporation
    Inventors: Joel G. Berger, Wei K. Chang, Elijah H. Gold, Arthur J. Elliott
  • Fused benzazepines, compositions of, and medical use thereof
    Patent number: 4973586
    Abstract: Disclosed are fused benzazepine compounds, pharmaceutical compositions including such compounds, methods of using such compounds, for example, in the treatment of psychoses and/or depression, and intermediates useful in the preparation of such compounds.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: November 27, 1990
    Assignee: Schering Corporation
    Inventors: Joel G. Berger, Wei K. Chang, Elijah H. Gold, John W. Clader
  • Treatment of hypertension
    Patent number: 4950783
    Abstract: Compositions containing (-)-5-{(R)-1-Hydroxy-2[(R)-1-methyl-3-phenylpropyl)amino]ethyl}salicylamid e exhibit potent vasodilating .beta.-adrenergic blocking properties and are useful for the treatment of hypertension.
    Type: Grant
    Filed: October 24, 1986
    Date of Patent: August 21, 1990
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Wei K. Chang
  • Phosphorus containing compounds as inhibitors of enkephalinases
    Patent number: 4853476
    Abstract: Novel phosphorous containing compounds and compositions containing said compounds inhibit the actions of enkephalinases in mammals. Methods for preparing said compounds and compositions and methods for their use to elicit analgesia and treat mental disorders are described.Useful intermediates for preparing the compounds are also described.
    Type: Grant
    Filed: September 24, 1987
    Date of Patent: August 1, 1989
    Assignee: Schering Corporation
    Inventors: Konstaninos S. Petrakis, Joel G. Berger, Elijah H. Gold
  • Antiglaucoma compositions and methods
    Patent number: 4840772
    Abstract: The present invention relates to ophthalmological pharmaceutical compositions comprising (benzothiadiazine, benzamide and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds and to methods for using said composition in reducing intraocular pressure, e.g., in the treatment of glaucoma.
    Type: Grant
    Filed: August 3, 1988
    Date of Patent: June 20, 1989
    Assignee: Schering Corporation
    Inventors: Robert Watkins, Ronald J. Doll, Bernard R. Neustadt, Elizabeth M. Smith, Charles V. Magatti, Elijah H. Gold
  • Preparation of angiotensin-converting enzyme inhibitors
    Patent number: 4831157
    Abstract: Novel compounds with angiotensin-converting enzyme inhibitory activity are disclosed. Such compounds are useful in the treatment of cardiovascular disorders, especially hypertension and congestive heart failure, and are useful in the treatment of glaucoma. Also disclosed is a novel process for preparing intermediates useful in the preparation of the claimed compounds.
    Type: Grant
    Filed: September 28, 1988
    Date of Patent: May 16, 1989
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Bernard R. Neustadt, Elizabeth M. Smith
  • Carboxyalkyl dipeptides and medical use thereof in treating hypertension and congestive heart failure
    Patent number: 4818749
    Abstract: The present invention relates to carboxyalkyl dipeptides which are inhibitors of angiotensin-converting enzyme and are useful as antihypertensive agents and in the treatment of congestive heart failure.The compounds of the present invention are compounds of the formulae ##STR1## and the pharmaceutically acceptable salts thereof, wherein R and R.sup.6 are the same or different and are hydroxy or lower alkoxy;R.sup.1 is benzyloxylower alkyl or benzylthiolower alkyl;R.sup.2 is benzylthiomethyl, 2-phyenylethylthiomethyl, napthylmethylthiomethyl, methylbenzylthiomethyl, 2-(carboxyphenyl)ethyl or 2-(alkoxycarbonylphenyl)ethyl) andR.sup.3 is hydrogen, lower alkyl or aminolower alkyl.
    Type: Grant
    Filed: November 4, 1987
    Date of Patent: April 4, 1989
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Bernard R. Neustadt, Elizabeth M. Smith
  • Carboxyalkyl dipeptides and anti-hypertensive use thereof
    Patent number: 4808573
    Abstract: The present invention relates to carboxyalkyl dipeptides which are inhibitors of angiotensin-converting enzyme and are useful as antihypertensive agents and in the treatment of congestive heart failure.The compounds of the present invention are compounds of the formulae ##STR1## and the pharmaceutically acceptable salts thereof, wherein R and R.sup.6 are the same or different and are hydroxy or lower alkoxy;R.sup.1 is benzyloxylower alkyl or benzylthiolower alkyl;R.sup.2 is benzylthiomethyl, 2-phenylethylthiomethyl, naphthylmethylthiomethyl, methylbenzylthiomethyl; 2-(carboxyphenyl)ethyl or 2-(alkoxycarbonylphenyl)ethyl; andR.sup.3 is hydrogen, lower alkyl or aminolower alkyl.
    Type: Grant
    Filed: March 23, 1987
    Date of Patent: February 28, 1989
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Bernard R. Neustadt, Elizabeth M. Smith
  • Antiglaucoma compositions and methods
    Patent number: 4783444
    Abstract: The present invention relates to ophthalmological pharmaceutical compositions comprising (benzothiadiazine, benzamide and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds and to methods for using said composition in reducing intraocular pressure, e.g., in the treatment of glaucoma.
    Type: Grant
    Filed: April 4, 1986
    Date of Patent: November 8, 1988
    Assignee: Schering Corporation
    Inventors: Robert Watkins, Ronald J. Doll, Bernard R. Neustadt, Elizabeth M. Smith, Charles V. Magatti, Elijah H. Gold
  • Process for preparing a specific diastereomer of a monoamino dicarboxylic acid ester
    Patent number: 4691049
    Abstract: (Benzothiadiazine, benzamido and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds are disclosed. Compounds of this invention are useful as antihypertensive agents.
    Type: Grant
    Filed: February 20, 1986
    Date of Patent: September 1, 1987
    Assignee: Schering Corporation
    Inventors: Ronald J. Doll, Bernard R. Neustadt, Elizabeth M. Smith, Charles V. Magatti, Elijah H. Gold
  • Treatment of hypertension
    Patent number: 4619919
    Abstract: Compositions containing (-)-5-{(R)-1-Hydroxy-2[(R)-1-methyl-3-phenylpropyl)amino]ethyl}salicylamid e exhibit potent vasodilating .beta.-adrenergic blocking properties and are useful for the treatment of hypertension.
    Type: Grant
    Filed: November 14, 1983
    Date of Patent: October 28, 1986
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Wei K. Chang
  • Angiotensin-converting enzyme inhibitors
    Patent number: 4587258
    Abstract: Novel compounds with angiotensin-converting enzyme inhibitory activity are disclosed. Such compounds are useful in the treatment of cardiovascular disorders, especially hypertension and congestive heart failure, and are useful in the treatment of glaucoma.
    Type: Grant
    Filed: July 30, 1984
    Date of Patent: May 6, 1986
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Bernard R. Neustadt, Elizabeth M. Smith
  • Antihypertensive agents
    Patent number: 4584285
    Abstract: (Benzothiadiazine, benzamido and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds are disclosed. Compounds of this invention are useful as antihypertensive agents.
    Type: Grant
    Filed: September 17, 1984
    Date of Patent: April 22, 1986
    Assignee: Schering Corporation
    Inventors: Ronald J. Doll, Bernard R. Neustadt, Elizabeth M. Smith, Charles V. Magatti, Elijah H. Gold
  • Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4477378
    Abstract: Disclosed are esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1-H-3-benzazepines represented by the general formula I ##STR1## wherein X is chloro, bromo or trifluoromethyl; R.sub.1 is alkyl, aralkyl, aryl, alkoxyalkyl, aryloxyalkyl, aralkoxyalkyl, cycloalkylalkyl, alkoxycarbonylalkyl, cycloalkyl, 1-adamantyl, cycloalkoxyalkyl, alkoxy, aralkoxy, cycloalkoxy or aryloxy; and the pharmaceutically acceptable acid addition salts thereof. The compounds show neuroleptic, antidepressive and antiaggressive activity.
    Type: Grant
    Filed: September 9, 1982
    Date of Patent: October 16, 1984
    Assignee: Schering Corp.
    Inventors: Elijah H. Gold, Wei K. Chang
  • 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids
    Patent number: 4470972
    Abstract: This invention relates to 7-carboxyalkyl-aminoacyl-1,4-adithia-7-azaspiro[4.4]nonane-8-carboxylic acids. The compounds of the invention are useful in the treatment of cardiovascular disorders and especially as antihypertensive agents.
    Type: Grant
    Filed: December 6, 1982
    Date of Patent: September 11, 1984
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Bernard R. Neustadt, Elizabeth M. Smith
  • Antiulcer tricyclic imidazo [1,2-a]pyridines
    Patent number: 4468400
    Abstract: There are disclosed certain substituted tricyclic imidazo[1,2-a]pyridines which are useful in the treatment of peptic ulcer diseases.
    Type: Grant
    Filed: December 20, 1982
    Date of Patent: August 28, 1984
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, James J. Kaminski, Chester Puchalski
  • Arylmethoxy-, arylmethylthio-, heteroarylmethoxy-, and heteroarylmethylthio-alkylaminoalcohols
    Patent number: 4379166
    Abstract: This invention relates to 5-(2-alkylamino-1-hydroxyethyl)salicylamides and 4-(2-alkylamino-1-hydroxyethyl)-2-(methylsulfinyl)phenols wherein the alkyl group is substituted by arylmethoxy, arylmethylthio, heteroarylmethoxy, or heteroarylmethylthio, pharmaceutical compositions thereof, and their use as cardiovascular agents.
    Type: Grant
    Filed: August 3, 1981
    Date of Patent: April 5, 1983
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Elijah H. Gold
  • (S)-8(1-Adamantanecarbonyloxy)-7-chloro-3-methyl-1-phenyl-2,3,4, 5-tetrahydro-1H-3-benzazepine
    Patent number: 4349472
    Abstract: This invention relates to esters of 7 halo-substituted 8-hydroxy-3 methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, processes for the preparation thereof, and pharmaceutical compositions containing them. The novel compounds of this invention show neuroleptic, antidepressive and antiaggressive activity.
    Type: Grant
    Filed: February 5, 1980
    Date of Patent: September 14, 1982
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Wei K. Chang