Patents by Inventor Elijah M. Bolotin

Elijah M. Bolotin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
    Patent number: 6162462
    Abstract: Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising `GMV` (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: December 19, 2000
    Assignees: New York University, Yissum Research Development Co. of the Hebrew Univ. of Jerusalem
    Inventors: Elijah M. Bolotin, Gilbert J. Grant, Yechezkel Barenholz, Herman Turndorf, Boris Piskoun