Abstract: The invention relates to a method for determining tumor aggressiveness in a subject diagnosed with prostate cancer and having a tumor, said method comprising (a) evaluating the level of cell differentiation in a sample comprising tumor-derived material from the said subject; and (b) evaluating the level of proliferating cells in the said sample. In a further aspect, the invention comprises determining the ratio between the level of proliferating cells and the level of cell differentiation and in the sample. The invention further relates to methods for determining the need of curative treatment in a subject diagnosed with prostate cancer, as well as to methods for treating prostate cancer in a subject in need thereof.

Abstract: The invention relates to methods for determining tumor aggressiveness and molecular subtype of metastases that are present, or that may eventually develop, in a subject diagnosed with prostate cancer. The methods of the invention comprise determining the molecular subtype of a sample by evaluating levels of subtype-associated gene transcripts. The invention further relates to methods for determining the metastatic potential in a subject diagnosed with prostate cancer and having a primary tumor, as well as to methods for determining the treatment for a subject diagnosed with prostate cancer metastasis.