Patent number: 9908893
Abstract: The thieno[2,3-b]pyridines of general formula (I), wherein R1 is Me, C6H5, 3,4,5-(OMe)3C6H2, NH2; R2 is H, CN, COMe, COOC1-4alkyl, COOC2H4OMe, COOC2H4OPr(n); R3 is C6H4R6, 3,4-OCH2O—C6H3; 2-furanyl; R6 is 4-Cl, 4-NO2, 4-N(C1-4alkyl)2, 3-(C1-4alkyloxy), 4-(C1-4alkyloxy), 3,4-(C1-4alkyloxy)2, 3,4,5-(C1-4alkyloxy)3; R4 is NH2, NHCOMe; R5 is CN, COMe, COC6H4R7; CO-(2-naphthyl); R7 is H, 4-F, 4-Cl, 3-OMe, 4-OMe, 2,4-(OMe)2, 3,4,5-(OMe)3 as multidrug resistance modulators to increase the effectiveness of chemotherapy in cancer treatment.
Type:
Grant
Filed:
June 11, 2013
Date of Patent:
March 6, 2018
Assignee:
LATVIAN INSTITUTE OF ORGANIC SYNTHESIS
Inventors:
Ivars Kalvins, Aivars Krauze, Signe Grinberga, Laura Krasnova, Elina Jaschenko, Ilona Domracheva, Ilze Adlere, Zigmars Andzans, Irina Shestakova, Gunars Duburs
Publication number: 20160137664
Abstract: The thieno[2,3-b]pyridines of general formula (I), wherein R1 is Me, C6H5, 3,4,5-(OMe)3C6H2, NH2; R2 is H, CN, COMe, COOC1-4alkyl, COOC2H4OMe, COOC2H4OPr(n); R3 is C6H4R6, 3,4-OCH2O—C6H3; 2-furanyl; R6 is 4-Cl, 4-NO2, 4-N(C1-4alkyl)2, 3-(C1-4alkyloxy), 4-(C1-4alkyloxy), 3,4-(C1-4alkyloxy)2, 3,4,5-(C1-4alkyloxy)3; R4 is NH2, NHCOMe; R5 is CN, COMe, COC6H4R7; CO-(2-naphthyl); R7 is H, 4-F, 4-Cl, 3-OMe, 4-OMe, 2,4-(OMe)2, 3,4,5-(OMe)3 as multidrug resistance modulators to increase the effectiveness of chemotherapy in cancer treatment.
Type:
Application
Filed:
June 11, 2013
Publication date:
May 19, 2016
Inventors:
Ivars KALVINS, Aivars KRAUZE, Signe GRINBERGA, Laura KRASNOVA, Elina JASCHENKO, Ilona DOMRACHEVA, Ilze ADLERE, Zigmars ANDZANS, Irina SHESTAKOVA, Gunars DUBURS
