Patents by Inventor Eliodor Ghenciu
Eliodor Ghenciu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230201839Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.Type: ApplicationFiled: December 21, 2022Publication date: June 29, 2023Inventors: Michael C. Pallas, James C. Nurse, Gary Lim, Theodore E. Straub, Eliodor Ghenciu, Evan Foster, Jorge Fonseca, Kevin Maher
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Patent number: 11590506Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.Type: GrantFiled: May 30, 2019Date of Patent: February 28, 2023Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Michael C. Pallas, James C. Nurse, Gary Lim, Theodore E. Straub, Eliodor Ghenciu, Evan Foster, Jorge Fonseca, Kevin Maher
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Publication number: 20230030218Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.Type: ApplicationFiled: October 10, 2022Publication date: February 2, 2023Inventors: Eliodor GHENCIU, Theodore E. STRAUB, Evan W. FOSTER, Michael C. PALLAS
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Patent number: 11493526Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.Type: GrantFiled: April 20, 2020Date of Patent: November 8, 2022Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Eliodor Ghenciu, Theodore E. Straub, Evan W. Foster, Michael C. Pallas
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Publication number: 20200319221Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.Type: ApplicationFiled: April 20, 2020Publication date: October 8, 2020Inventors: Eliodor GHENCIU, Theodore E. STRAUB, Evan W. FOSTER, Michael C. PALLAS
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Patent number: 10627421Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.Type: GrantFiled: March 15, 2013Date of Patent: April 21, 2020Assignee: Life Technologies CorporationInventors: Eliodor Ghenciu, Theodore E. Straub, Evan W. Foster, Michael C. Pallas
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Publication number: 20190381502Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.Type: ApplicationFiled: May 30, 2019Publication date: December 19, 2019Inventors: Michael C. Pallas, James C. Nurse, Gary Lim, Theodore E. Straub, Eliodor Ghenciu, Evan Foster, Jorge Fonseca, Kevin Maher
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Publication number: 20150080247Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.Type: ApplicationFiled: March 15, 2013Publication date: March 19, 2015Inventors: Michael C. Pallas, James C. Nurse, Gary Lim, Theodore E. Straub, Eliodor Ghenciu, Evan W. Foster, Jorge Fonseca, Kevin Maher
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Publication number: 20150051118Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.Type: ApplicationFiled: March 15, 2013Publication date: February 19, 2015Inventors: Eliodor Ghenciu, Theodore E. Straub, Evan W. Foster, Michael C. Pallas
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Publication number: 20150044686Abstract: An article for holding a plurality of biological samples includes a substrate a substrate comprising a first surface and an opposing second surface and a plurality of reaction sites in the substrate. Each of the reaction sites extends from an opening in the first surface to an opening in the second surface. The reaction sites comprise a hexagonal shape and are configured to provide sufficient surface tension by capillary action to hold respective biological samples. The reaction sites have a density over at least a portion of the surfaces that is at least 170 holes per square millimeter. At least one of the surfaces may have a surface roughness characterized by an arithmetic average roughness (Ra) that is less than or equal to 5 nanometers.Type: ApplicationFiled: March 15, 2013Publication date: February 12, 2015Applicant: Life Technologies CorporationInventors: Michael Pallas, James C. Nurse, Kevin Maher, Jorge Fonseca, Eliodor Ghenciu, Evan Foster
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Publication number: 20070111533Abstract: A method and composition for removing silicon-containing sacrificial layers from Micro Electro Mechanical System (MEMS) and other semiconductor substrates having such sacrificial layers is described. The etching compositions include a supercritical fluid (SCF), an etchant species, a co-solvent, and optionally a surfactant. Such etching compositions overcome the intrinsic deficiency of SCFs as cleaning reagents, viz., the non-polar character of SCFs and their associated inability to solubilize polar species that must be removed from the semiconductor substrate. The resultant etched substrates experience lower incidents of stiction relative to substrates etched using conventional wet etching techniques.Type: ApplicationFiled: January 8, 2007Publication date: May 17, 2007Inventors: Michael Korzenski, Thomas Baum, Chongying Xu, Eliodor Ghenciu
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Publication number: 20060204427Abstract: Certain applicator liquids and method of making the applicator liquids are described. The applicator liquids can be used to form nanotube films or fabrics of controlled properties. An applicator liquid for preparation of a nanotube film or fabric includes a controlled concentration of nanotubes dispersed in a liquid medium containing water. The controlled concentration is sufficient to form a nanotube fabric or film of preselected density and uniformity.Type: ApplicationFiled: December 15, 2005Publication date: September 14, 2006Applicant: Nantero, Inc.Inventors: Eliodor Ghenciu, Tzong-Ru Han, Ramesh Sivarajan, Thomas Rueckes, Rahul Sen, Brent Segal, Jonathan Ward
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Publication number: 20060122085Abstract: A composition including supercritical fluid and at least one additive selected from fluoro species, and primary and/or secondary amines, optionally with co-solvent, low k material attack-inhibitor(s) and/or surfactant(s). The composition has particular utility for cleaning of semiconductor wafers to remove post-ashing residues therefrom.Type: ApplicationFiled: January 27, 2006Publication date: June 8, 2006Inventors: Michael Korzenski, Chongying Xu, Thomas Baum, David Minsek, Eliodor Ghenciu
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Publication number: 20060073998Abstract: A post-etch residue cleaning composition for cleaning ashed or unashed aluminum/SiN/Si post-etch residue from small dimensions on semiconductor substrates. The cleaning composition contains supercritical CO2 (SCCO2), alcohol, fluoride source, an aluminum ion complexing agent and, optionally, corrosion inhibitor. Such cleaning composition overcomes the intrinsic deficiency of SCCO2 as a cleaning reagent, viz., the non-polar character of SCCO2 and its associated inability to solubilize species such as inorganic salts and polar organic compounds that are present in the post-etch residue and that must be removed from the semiconductor substrate for efficient cleaning. The cleaning composition enables damage-free, residue-free cleaning of substrates having ashed or unashed aluminum/SiN/Si post-etch residue thereon.Type: ApplicationFiled: November 14, 2005Publication date: April 6, 2006Inventors: Michael Korzenski, Eliodor Ghenciu, Chongying Xu, Thomas Baum
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Publication number: 20060065294Abstract: Drying of patterned wafers is achieved in a manner effecting removal of water from the patterned wafers without collapse or deterioration of the pattern structures thereof. The drying is carried out in one aspect of the invention with a composition containing supercritical fluid, and at least one water-reactive agent that chemically reacts with water to form reaction product(s) more soluble in the supercritical fluid than water. Various methodologies are described for use of supercritical fluids to dry patterned wafers, which avoid the (low water solubility) deficiency of supercritical fluids such as supercritical CO2.Type: ApplicationFiled: November 10, 2005Publication date: March 30, 2006Inventors: Chongying Xu, Michael Korzenski, Thomas Baum, Alexander Borovik, Eliodor Ghenciu
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Publication number: 20060040840Abstract: A photoresist cleaning composition for removing photoresist and ion implanted photoresist from semiconductor substrates. The cleaning composition contains supercritical CO2 (SCCO2) and alcohol for use in removing photoresist that is not ion-implanted. When the photoresist has been subjected to ion implantation, the cleaning composition additionally contains a fluorine ion source. Such cleaning composition overcomes the intrinsic deficiency of SCCO2 as a cleaning reagent, viz., the non-polar character of SCCO2 and its associated inability to solubilize species such as inorganic salts and polar organic compounds that are present in the photoresist and that must be removed from the semiconductor substrate for efficient cleaning. The cleaning composition enables damage-free, residue-free cleaning of substrates having photoresist or ion implanted photoresist thereon.Type: ApplicationFiled: October 6, 2005Publication date: February 23, 2006Inventors: Michael Korzenski, Eliodor Ghenciu, Chongying Xu, Thomas Baum
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Publication number: 20050118813Abstract: A method and composition for removing silicon-containing sacrificial layers from Micro Electro Mechanical System (MEMS) and other semiconductor substrates having such sacrificial layers is described. The etching compositions include a supercritical fluid (SCF), an etchant species, a co-solvent, and optionally a surfactant. Such etching compositions overcome the intrinsic deficiency of SCFs as cleaning reagents, viz., the non-polar character of SCFs and their associated inability to solubilize polar species that must be removed from the semiconductor substrate. The resultant etched substrates experience lower incidents of stiction relative to substrates etched using conventional wet etching techniques.Type: ApplicationFiled: February 19, 2004Publication date: June 2, 2005Inventors: Michael Korzenski, Thomas Baum, Chongying Xu, Eliodor Ghenciu
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Publication number: 20050118832Abstract: A method and composition for removing silicon-containing sacrificial layers from Micro Electro Mechanical System (MEMS) substrates having such sacrificial layers is described. The etching compositions include a supercritical fluid, an etchant species, a co-solvent, and optionally a surfactant. Such etching compositions overcome the intrinsic deficiency of SCFs as cleaning reagents, viz., the non-polar character of SCFs and their associated inability to solubilize polar species that must be removed from the semiconductor substrate. The resultant etched MEMS substrates experience lower incidents of stiction relative to MEMS substrates etched using conventional wet etching techniques.Type: ApplicationFiled: December 1, 2003Publication date: June 2, 2005Inventors: Michael Korzenski, Thomas Baum, Eliodor Ghenciu