Abstract: A device for determining the amount or concentration of an analyte in a fluid sample and a flow rate of the fluid sample in a channel is provided. The device includes a chamber including a channel and an opening, the channel in fluid communication with the opening. The device further includes a wicking component positioned adjacent to the opening configured to receive an amount of fluid from the channel. The device may further include an analyte sensor positioned on the wicking component, the analyte sensor configured to detect an analyte in fluid in contact with the analyte sensor, wherein the wicking component is configured to contact the amount of fluid with the analyte sensor. Alternatively the device may include at least one pair of electrodes configured to determine a flow rate of the fluid in the channel.

Abstract: Described are devices for and methods of modulating a fluid sample. The devices (10, 40, 60, 80, 100, 130, 160, 220) include at least one sample-modulating component (20, 76, 78, 90, 110, 112, 116, 150, 152, 154, 162, 164, 182, 184, 186, 222, and 230) and, in some embodiments, two or more sample-modulating components.

Abstract: A device for determining the amount or concentration of an analyte in a fluid sample and a flow rate of the fluid sample in a channel is provided. The device includes a chamber including a channel and an opening the channel in fluid communication with the opening. The device further includes a wicking component positioned adjacent to the opening configured to receive an amount of fluid from the channel. The device may further include an analyte sensor positioned on the wicking component, the analyte sensor configured to detect an analyte in fluid in contact with the analyte sensor, wherein the wicking component is configured to contact the amount of fluid with the analyte sensor. Alternatively the device may include at least one pair of electrodes configured to determine a flow rate of the fluid in the channel.

Abstract: Hydrogel-based or aerogel-based devices and methods for pretreatment of a sample. The devices and method may include an aerogel-based device for pretreating a sample comprising at least one aerogel; a hydrogel-based device for pretreating a sample comprising at least one hydrogel; or a combination aerogel-based and hydrogel-based device for pretreating a sample comprising at least one aerogel in fluid communication with at least one hydrogel.

Abstract: A device for determining the amount or concentration of an analyte in a fluid sample and a flow rate of the fluid sample in a channel is provided. The device includes a chamber including a channel and an opening the channel in fluid communication with the opening. The device further includes a wicking component positioned adjacent to the opening configured to receive an amount of fluid from the channel. The device may further include an analyte sensor positioned on the wicking component, the analyte sensor configured to detect an analyte in fluid in contact with the analyte sensor, wherein the wicking component is configured to contact the amount of fluid with the analyte sensor. Alternatively the device may include at least one pair of electrodes configured to determine a flow rate of the fluid in the channel.

Abstract: Described are devices for and methods of modulating a fluid sample. The devices (10, 40, 60, 80, 100, 130, 160, 220) include at least one sample-modulating component (20, 76, 78, 90, 110, 112, 116, 150, 152, 154, 162, 164, 182, 184, 186, 222, and 230) and, in some embodiments, two or more sample-modulating components.

Abstract: A device (200) for sensing a biofluid (18) includes at least one analyte-consuming sensor (220) for measuring at least a first analyte concentration of an analyte in the biofluid (18) and at least one additional component (248). The at least one additional component (248) maintains analyte-consuming sensor (220) measurements within 20% of the first concentration measurement if a biofluid (18) sample flow rate is less than or equal to 2 times a first biofluid (18) sample flow rate measurement as measured by the device (200). A method for sensing a biofluid (18) includes measuring a first analyte concentration of an analyte in the biofluid (18) using an analyte-consuming sensor (220), measuring a first biofluid sample flow rate, and maintaining a subsequent analyte concentration measurement within 20% of the first analyte concentration measurement when a subsequently measured biofluid (18) flow rate is less than or equal to 2 times the first biofluid sample flow rate.