Patents by Inventor Eliot M. Rosen
Eliot M. Rosen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10266490Abstract: Radioprotector compounds including 3,3?-diindolylmethane (DIM) analogs, are provided. Further provided are methods for their use in reducing or preventing radiation damage, killing a tumor cell and protecting a non-tumor cell, and treating cancer.Type: GrantFiled: March 14, 2013Date of Patent: April 23, 2019Assignee: Georgetown UniversityInventors: Eliot M. Rosen, Milton Brown, Saijun Fan, Thomas Walls, Kathryn E. Ditmer
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Patent number: 10160716Abstract: The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also encompasses methods for treating or preventing diseases and disorders associated with abnormal cell growth, for example, treating or preventing cancer or tumor growth, which methods include administering to a mammal in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound of the invention or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 30, 2017Date of Patent: December 25, 2018Assignee: Georgetown UniversityInventors: Eliot M. Rosen, York A. Tomita, Milton Brown
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Publication number: 20180148401Abstract: The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also encompasses methods for treating or preventing diseases and disorders associated with abnormal cell growth, for example, treating or preventing cancer or tumor growth, which methods include administering to a mammal in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound of the invention or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 30, 2017Publication date: May 31, 2018Inventors: Eliot M. Rosen, York A. Tomita, Milton Brown
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Patent number: 9695108Abstract: The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also encompasses methods for treating or preventing diseases and disorders associated with abnormal cell growth, for example, treating or preventing cancer or tumor growth, which methods include administering to a mammal in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound of the invention or a pharmaceutically acceptable salt thereof.Type: GrantFiled: August 23, 2013Date of Patent: July 4, 2017Assignee: Georgetown UniversityInventors: Eliot M. Rosen, York A. Tomita, Milton Brown
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Patent number: 9603844Abstract: The present invention provides methods of inhibiting abnormal growth of cells, with the methods comprising contacting the cells with at least one of the sensitizing compounds disclosed herein in an amount sufficient to inhibit cell growth. The present invention also provides methods of treating and/or reducing the likelihood of being diagnosed with breast cancer, with the methods comprising administering to a subject in need of treatment thereof at least one of the sensitizing compounds disclosed herein.Type: GrantFiled: October 22, 2013Date of Patent: March 28, 2017Assignee: Georgetown UniversityInventors: Eliot M Rosen, York A Tomita
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Publication number: 20150344440Abstract: The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also encompasses methods for treating or preventing diseases and disorders associated with abnormal cell growth, for example, treating or preventing cancer or tumor growth, which methods include administering to a mammal in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound of the invention or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: August 23, 2013Publication date: December 3, 2015Inventors: Eliot M. Rosen, York A. Tomita, Milton Brown
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Publication number: 20150265590Abstract: The present invention provides methods of inhibiting abnormal growth of cells, with the methods comprising contacting the cells with at least one of the sensitizing compounds disclosed herein in an amount sufficient to inhibit cell growth. The present invention also provides methods of treating and/or reducing the likelihood of being diagnosed with breast cancer, with the methods comprising administering to a subject in need of treatment thereof at least one of the sensitizing compounds disclosed herein.Type: ApplicationFiled: October 22, 2013Publication date: September 24, 2015Applicant: GEORGETOWN UNIVERSITYInventors: Eliot M. Rosen, York A. Tomita
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Publication number: 20150044293Abstract: Radioprotector compounds including 3,3?-diindolylmethane (DIM) analogs, are provided. Further provided are methods for their use in reducing or preventing radiation damage, killing a tumor cell and protecting a non-tumor cell, and treating cancer.Type: ApplicationFiled: March 14, 2013Publication date: February 12, 2015Applicant: Georgetown UniversityInventors: Eliot M. Rosen, Milton Brown, Saijun Fan, Thomas Walls, Kathryn E. Ditmer
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Patent number: 6498144Abstract: This invention relates to a method of enhancing wound healing and to a method of enhancing organ transplantation utilizing scatter factor, either alone or in combination with a growth factor.Type: GrantFiled: June 23, 2000Date of Patent: December 24, 2002Assignee: North Shore - Long Island Jewish Research InstituteInventors: Itzhak D. Goldberg, Eliot M. Rosen
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Patent number: 6432406Abstract: This invention relates to a method of enhancing wound healing and to a method of enhancing organ transplantation utilizing scatter factor, either alone or in combination with a growth factor.Type: GrantFiled: July 26, 2000Date of Patent: August 13, 2002Assignee: North Shore - Long Island Jewish Research InstituteInventors: Itzhak D. Goldberg, Eliot M. Rosen
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Patent number: 6013624Abstract: The present invention provides a novel method of inducing proliferation and migration of endothelial cells in a subject comprising administering an amount of scatter factor effective to induce the proliferation and migration of endothelial cells in the subject.Type: GrantFiled: November 25, 1998Date of Patent: January 11, 2000Assignee: North Shore University Hospital Research CorporationInventors: Itzhak D. Goldberg, Eliot M. Rosen
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Patent number: 6011009Abstract: The present invention provides a novel method of determining the presence of angiogenesis in a subject comprising detecting the presence of scatter factor in the subject.Type: GrantFiled: November 25, 1998Date of Patent: January 4, 2000Assignee: North Shore University Hospital Research CorporationInventors: Itzhak D. Goldberg, Eliot M. Rosen
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Patent number: 5997868Abstract: The present invention provides a novel method of inhibiting angiogenesis in a subject by blocking the ability of endogenous scatter factor to promote angiogenesis in the subject. The endogenous scatter factor may be blocked by using an inhibitor to scatter factor, such as an antibody.Type: GrantFiled: March 31, 1998Date of Patent: December 7, 1999Assignee: North Shore University Hospital Research CorporationInventors: Itzhak D. Goldberg, Eliot M. Rosen
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Patent number: 5965523Abstract: The present invention provides a novel method of enhancing transplanted tissue in a subject comprising administering an amount of scatter factor effective to promote angiogenesis and enhance tissue transplantation in the subject.Type: GrantFiled: March 31, 1998Date of Patent: October 12, 1999Assignee: North Shore University Hospital Research CorporationInventors: Itzhak D. Goldberg, Eliot M. Rosen
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Patent number: 5919759Abstract: This invention relates to a method of promoting angiogenesis utilizing scatter factor, either alone or in combination with a growth factor.Type: GrantFiled: March 31, 1998Date of Patent: July 6, 1999Assignee: North Shore University Hospital Research CorporationInventors: Itzhak D. Goldberg, Eliot M. Rosen
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Patent number: 5837676Abstract: This invention relates to a method of enhancing wound healing utilizing scatter factor, either alone or in combination with a growth factor.Type: GrantFiled: November 13, 1996Date of Patent: November 17, 1998Assignee: Long Island Jewish Medical CenterInventors: Itzhak D. Goldberg, Eliot M. Rosen
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Patent number: 5707624Abstract: Methods of treating Kaposi's sarcoma (KS) by inhibiting the effect of scatter factor (SF), also known as hepatocyte growth factor (HGF), are provided. The methods of the present invention include antibody therapy wherein an antibody to SF is introduced into a patient to decrease active SF levels thereby decreasing the incidence of new tumors as well as leading to regression of established tumors by blocking SF-mediated tumor cell proliferation and neovascularization. The present invention further provides methods of inhibiting the effects of SF by introducing into a patient means for inhibiting binding of SF to the SF receptor, the c-met proto-oncogen. Means for inhibiting SF binding to the receptor include introducing into a patient an antibody to the c-met receptor or introducing a non-stimulatory ligand that will bind and thereby inhibit the receptor.Type: GrantFiled: June 3, 1994Date of Patent: January 13, 1998Assignee: The Regents of the University of MichiganInventors: Brian J. Nickoloff, Yahti M. Naidu, Eliot M. Rosen, Peter J. Polverini
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Patent number: 5656443Abstract: This invention relates to a method of diagnosing and screening for transitional cell carcinoma of the bladder. Urine from an individual suspected of having transitional cell carcinoma of the bladder is analyzed for the presence of an increased level of scatter factor, an increased level of scatter factor indicating that said individual has bladder cancer. This invention further relates to a method of monitoring bladder cancer activity by measuring the level of scatter factor in urine, and to a method of determining the prognosis of an individual having bladder cancer by measuring the level of scatter factor in tumor extract from the individual.Type: GrantFiled: July 29, 1994Date of Patent: August 12, 1997Assignee: Long Island Jewish Medical CenterInventors: Itzhak D. Goldberg, Eliot M. Rosen, Gary H. Weiss