Abstract: A method comprising receiving images depicting stained target tissue, segmenting the images into cell type and region type segmentations, extracting cell phenotype features from an analysis of the stains for cell type segmentations, clustering the cell type segmentations, computing feature vectors each including the respective cell phenotype features, and an indication of a location of the cell type segmentation relative to region type segmentation(s), creating a cell-graph based on the feature vectors of cell type segmentations and/or clusters, wherein each node denotes respective cell type segmentation and/or respective cluster and includes the feature vector, and edges represent a physical distance between cell type segmentations and/or clusters corresponding to the respective nodes, inputting the cell-graph into a graph neural network, and obtaining an indication of a target therapy likely to be effective for treatment of medical condition in the subject as an outcome of the graph neural network.

Abstract: A device including a sheath having a proximal end, a distal end, and a lumen extending through the sheath from the proximal end to the distal end, wherein the sheath is biased to a released position; a pull wire extending along the sheath and being coupled to the sheath at the distal end, wherein the pull wire and the sheath are configured to cooperate such that pulling the pull wire toward the proximal end causes the distal end to assume an active position, and such that release of the pull wire causes the distal end to return to the released position; and a control portion coupled to the proximal end of the sheath and to the pull wire, wherein the control portion includes a control element operable to selectively pull the pull wire toward the proximal end of the sheath or to release the pull wire.

Abstract: The present invention is disclosing several methods related to intra-body navigation of radiopaque instrument through natural body cavities. One of the methods is disclosing the pose estimation of the imaging device using multiple images of radiopaque instrument acquired in the different poses of imaging device and previously acquired imaging. The other method allows to resolve the radiopaque instrument localization ambiguity using several approaches, such as radiopaque markers and instrument trajectory tracking.

Abstract: A device for use during a medical imaging process, the device including a support structure and a plurality of radiopaque markers, the support structure configured to be positioned in proximity to at least a portion of a body of a patient during the medical imaging process, the plurality of radiopaque markers attached to the support structure, the plurality of radiopaque markers being positioned in a pattern such that an image capturing a given portion of the pattern is unique from an image capturing any other given portion of the pattern.

Abstract: A device for use during a medical imaging process, the device including a support structure and a plurality of radiopaque markers, the support structure configured to be positioned in proximity to at least a portion of a body of a patient during the medical imaging process, the plurality of radiopaque markers attached to the support structure, the plurality of radiopaque markers being positioned in a pattern such that an image capturing a given portion of the pattern is unique from an image capturing any other given portion of the pattern.

Abstract: The present invention is disclosing several methods related to intra-body navigation of radiopaque instrument through natural body cavities. One of the methods is disclosing the pose estimation of the imaging device using multiple images of radiopaque instrument acquired in the different poses of imaging device and previously acquired imaging. The other method allows to resolve the radiopaque instrument localization ambiguity using several approaches, such as radiopaque markers and instrument trajectory tracking.

Abstract: The present invention is disclosing several methods related to intra-body navigation of radiopaque instrument through natural body cavities. One of the methods is disclosing the pose estimation of the imaging device using multiple images of radiopaque instrument acquired in the different poses of imaging device and previously acquired imaging. The other method allows to resolve the radiopaque instrument localization ambiguity using several approaches, such as radiopaque markers and instrument trajectory tracking.

Abstract: A device for use during a medical imaging process, the device including a support structure and a plurality of radiopaque markers, the support structure configured to be positioned in proximity to at least a portion of a body of a patient during the medical imaging process, the plurality of radiopaque markers attached to the support structure, the plurality of radiopaque markers being positioned in a pattern such that an image capturing a given portion of the pattern is unique from an image capturing any other given portion of the pattern.

Abstract: A device including an applicator having a proximal end, a distal end, an internal channel extending therebetween; a shaft having a proximal end, a distal end, and an internal channel extending therebetween, the shaft being configured to be slidably received within the internal channel of the applicator; a catheter configured to be positioned within the internal channel of the shaft; a guide wire positioned within the catheter; a connector configured to be attached to the distal end of the applicator, to engage a bronchoscope, and so as to be rotatable with respect to the shaft; a handle attached to the proximal end of the applicator, the handle including a trigger operable to selectively lock or unlock sliding motion of the shaft with respect to the applicator; and a radio opaque material attached to an outer portion of the device and positioned in a predetermined pattern.

Abstract: The present invention is disclosing several methods related to intra-body navigation of radiopaque instrument through natural body cavities. One of the methods is disclosing the pose estimation of the imaging device using multiple images of radiopaque instrument acquired in the different poses of imaging device and previously acquired imaging. The other method allows to resolve the radiopaque instrument localization ambiguity using several approaches, such as radiopaque markers and instrument trajectory tracking.