Abstract: A composition is described for the prevention and treatment of skin diseases, in particular in the veterinary field. The composition of the invention includes a synergistic association of Lactobacilli and plant extracts, which has been shown to be significantly effective in supporting the functionality of the skin barrier and restoring homeostasis of microbial populations. In fact, the composition performs a direct action on the skin surface by preventing and contrasting skin alterations, promoting the balance of the microbiota, strengthening the immune system and carrying out antioxidant activity.