Patents by Inventor Elisa Danieli

Elisa Danieli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tyrosine ligation process
    Patent number: 9149541
    Abstract: A process is provided for preparing a conjugate of Formula (I-A) or (I) comprising a polypeptide containing n number of tyrosine units, where n is an integer greater than or equal to 1, dispersed within the amino acid chain having and amino terminus end (A1) and an acid terminus end (A2) of the protein or polypeptide and having a weight average molecular weight equal to or greater than 10,000 Daltons (10 kDa), wherein the conjugate comprises a number m of tyrosine conjugates (modified tyrosine residues) as depicted in Formula (I-A) or (I), where m is at least one and is less than or equal to n: where X, Lg, L and R are as defined herein.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: October 6, 2015
    Assignee: NOVARTIS AG
    Inventors: Roberto Adamo, Martin Allen, Francesco Berti, Elisa Danieli, Qi-Ying Hu
  • TYROSINE LIGATION PROCESS
    Publication number: 20140141034
    Abstract: A process is provided for preparing a conjugate of Formula (I-A) or (I) comprising a polypeptide containing n number of tyrosine units, where n is an integer greater than or equal to 1, dispersed within the amino acid chain having and amino terminus end (A1) and an acid terminus end (A2) of the protein or polypeptide and having a weight average molecular weight equal to or greater than 10,000 Daltons (10 kDa), wherein the conjugate comprises a number m of tyrosine conjugates (modified tyrosine residues) as depicted in Formula (I-A) or (I), where m is at least one and is less than or equal to n: where X, Lg, L and R are as defined herein.
    Type: Application
    Filed: July 5, 2012
    Publication date: May 22, 2014
    Applicant: NOVARTIS AG
    Inventors: Roberto Adamo, Martin Allen, Francesco Berti, Elisa Danieli, Qi-Ying Hu
  • COMPOUNDS
    Publication number: 20130315959
    Abstract: The invention provides a synthetic C. difficile PS-II cell wall saccharide. The invention also provides a process for purifying C. difficile PS-II saccharide from C. difficile bacterial cells resulting in reduced contamination. The saccharides may be used in vaccines, particularly as conjugates with carrier proteins.
    Type: Application
    Filed: December 23, 2011
    Publication date: November 28, 2013
    Applicant: NOVARTIS AG
    Inventors: Paolo Costantino, Roberto Adamo, Maria Rosaria Romano, Elisa Danieli, Francesco Berti, Emilia Cappelliti, Luigi Lay