Patents by Inventor ELISA FRANCO

ELISA FRANCO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for regulating proteins and nucleic acids activities
    Patent number: 11965159
    Abstract: Compositions and methods for conditionally regulating activities of CRISPR-Cas systems. In some embodiments, the methods comprise providing an inactive guide RNA comprising a regulatory domain bound by a lock nucleic acid different from the guide RNA; and displacing the lock nuclei acid from the regulatory domain by a trigger nucleic acid, thereby activating the guide RNA, wherein the activated guide RNA forms a complex with a Cas enzyme.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: April 23, 2024
    Assignees: The Broad Institute, Inc., The Brigham and Women's Hospital, Inc., The Regents of the University of California
    Inventors: Amit Choudhary, Kurt Cox, Hari Subramanian, Elisa Franco
  • Inhibitors of RNA guided nucleases and uses thereof
    Patent number: 11787795
    Abstract: Compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: October 17, 2023
    Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Amit Choudhary, Peng Wu, Basudeb Maji, Elisa Franco, Hari K. K. Subramanian
  • CRISPR protein inhibitors
    Patent number: 11760984
    Abstract: The embodiments disclosed herein utilize fluorescence polarization based preliminary screen to identify a putative set of Cas inhibitors from an initial set of candidate inhibitors. The primary screening assay is followed by secondary screening assay to validate the putative set of inhibitors selected by the preliminary screen. In some embodiments, the present disclosure includes compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: September 19, 2023
    Inventors: Amit Choudhary, Kurt Cox, Basudeb Maji, Peng Wu, Hari Subramanian, Elisa Franco
  • CRISPR PROTEIN INHIBITORS
    Publication number: 20200354701
    Abstract: The embodiments disclosed herein utilize fluorescence polarization based preliminary screen to identify a putative set of Cas inhibitors from an initial set of candidate inhibitors. The primary screening assay is followed by secondary screening assay to validate the putative set of inhibitors selected by the preliminary screen. In some embodiments, the present disclosure includes compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.
    Type: Application
    Filed: October 31, 2018
    Publication date: November 12, 2020
    Inventors: Amit CHOUDHARY, Kurt COX, Basudeb MAJI, Peng WU, Hari SUBRAMANIAN, Elisa FRANCO
  • COMPOSITIONS AND METHODS FOR REGULATING PROTEINS AND NUCLEIC ACIDS ACTIVITIES
    Publication number: 20200239879
    Abstract: Compositions and methods for conditionally regulating activities of CRISPR-Cas systems. In some embodiments, the methods comprise providing an inactive guide RNA comprising a regulatory domain bound by a lock nucleic acid different from the guide RNA; and displacing the lock nuclei acid from the regulatory domain by a trigger nucleic acid, thereby activating the guide RNA, wherein the activated guide RNA forms a complex with a Cas enzyme.
    Type: Application
    Filed: January 29, 2020
    Publication date: July 30, 2020
    Inventors: Amit Choudhary, Kurt Cox, Hari Subramanian, Elisa Franco
  • INHIBITORS OF RNA GUIDED NUCLEASES AND USES THEREOF
    Publication number: 20190263807
    Abstract: Compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.
    Type: Application
    Filed: October 31, 2017
    Publication date: August 29, 2019
    Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: AMIT CHOUDHARY, PENG WU, BASUDEB MAJI, ELISA FRANCO, HARI K.K. SUBRAMANIAN