Patents by Inventor Elisa Landoni

Elisa Landoni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for the Reduction of Chimeric Antigen Receptor Tonic Signaling
    Publication number: 20230242666
    Abstract: The present disclosure relates to methods and compositions related to Chimeric Antigen Receptors (“CARs”) and modifications to the framework sequences to eliminate tonic signaling. The compositions include modified binding members having a binding specificity to chondroitin sulfate proteoglycan 4 (CSPG4) and are stable when prepared as single chain antibody (scFv) and incorporated into CARs. The methods further include nucleic acid constructs for the expression of CSPG4 CARs, and the application of the CSPG4 CAR to therapeutic methods for the treatment of cancer. The present disclosure also relates to the modification of humanized framework sequences.
    Type: Application
    Filed: June 29, 2021
    Publication date: August 3, 2023
    Applicants: Cell Medica, Inc., The University of North Carolina Chapel Hill
    Inventors: Gianpietro DOTTI, Elisa LANDONI, Miriam DROSTE, Abdijapar SHAMSHIEV
  • MODIFIED CELLS FOR IMMUNOTHERAPY
    Publication number: 20190048085
    Abstract: The present invention relates to engineered immune cells expressing antigen receptors, such as a T cell receptor (TCR) or a chimeric antigen receptor (CAR), as well as antibody targeting PD-L1. Also provided are related nucleic acids, vectors, compositions and method for enhancing the immune response towards cancers and pathogens.
    Type: Application
    Filed: February 24, 2017
    Publication date: February 14, 2019
    Inventors: Gianpietro Dotti, Elisa Landoni, Abdijapar Shamshiev, Titus Kretzschmar, Miriam Droste, Douglas Phillips