Abstract: Compositions of pro-chelator compounds are described herein. The pro-chelators may be activated in reducing conditions, such as in the intracellular space, so as to sequester metals such as iron. The pro-chelators may be used to target malignant cells or in the treatment in a condition associated with metal ion disregulation.

Abstract: Pro-chelator compositions featuring disulfide masks that upon activation yield active chelators. The pro-chelator compositions may be activated intracellularly, for example within cells featuring metal ion dysregulation, cells that proliferate abnormally, etc. The pro-chelators of the present invention include thiosemicarbazones, semicarbazones, and aroyl hydrazones. The pro-chelator compositions of the present invention may be used for a variety of purposes including inhibiting cell proliferation, or treating conditions associated with metal ion dysregulation or abnormal cell proliferation.

Abstract: Pro-chelator compositions featuring disulfide masks that upon activation yield active chelators. The pro-chelator compositions may be activated intracellularly, for example within cells featuring metal ion dysregulation, cells that proliferate abnormally, etc. The pro-chelators of the present invention include thiosemicarbazones, semicarbazones, and aroyl hydrazones. The pro-chelator compositions of the present invention may be used for a variety of purposes including inhibiting cell proliferation, or treating conditions associated with metal ion dysregulation or abnormal cell proliferation.

Abstract: Compositions of pro-chelator compounds are described herein. The pro-chelators may be activated in reducing conditions, such as in the intracellular space, so as to sequester metals such as iron. The pro-chelators may be used to target malignant cells or in the treatment in a condition associated with metal ion disregulation.

Abstract: Compositions of iron prochelator compounds conjugated to a carbohydrate moiety are described herein. The glycoconjugates are prochelators that are activated in reducing conditions, such as in the intracellular space, so as to sequester iron. The glycoconjugate molecules are taken up by cells via the glucose transporter and may be used to target malignant cells.

Abstract: The present invention provides redox-activated chelators and methods for using the same to treat cancer. In one particular embodiment, the redox-activated chelator is of the formula: wherein each of m and n is an integer from 0 to 4; each of Ar1 and Ar2 is independently aryl or heteroaryl; each of R1, R2, R5 and R6 is independently hydrogen, alkyl, aryl, electron withdrawing group or an anion stabilizing group; each of R3 and R4 is independently alkyl, halide, or other electron withdrawing group or an anion stabilizing group.

Abstract: The present invention provides redox-activated chelators and methods for using the same to treat cancer. In one particular embodiment, the redox-activated chelator is of the formula: wherein each of m and n is an integer from 0 to 4; each of Ar1 and Ar2 is independently aryl or heteroaryl; each of R1, R2, R5 and R6 is independently hydrogen, alkyl, aryl, electron withdrawing group or an anion stabilizing group; each of R3 and R4 is independently alkyl, halide, or other electron withdrawing group or an anion stabilizing group.

Abstract: The present invention provides redox-activated chelators and methods for using the same to treat cancer. In one particular embodiment, the redox-activated chelator is of the formula: wherein each of m and n is an integer from 0 to 4; each of Ar1 and Ar2 is independently aryl or heteroaryl; each of R1, R2, R5 and R6 is independently hydrogen, alkyl, aryl, electron withdrawing group or an anion stabilizing group; each of R3 and R4 is independently alkyl, halide, or other electron withdrawing group or an anion stabilizing group.