Patents by Inventor Elisa Verza

Elisa Verza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Water-soluble solid pharmaceutical inclusion complexes and their aqueous solutions for oral, ophthalmic, topical or parenteral use containing a macrolide and certain cyclodextrins
    Patent number: 9169269
    Abstract: This invention relates to new water-soluble solid pharmaceutical inclusion complexes and their aqueous solutions for oral, ophthalmic, topical or parenteral use containing a macrolide and certain cyclodextrins. More particularly the invention relates to new water-soluble solid pharmaceutical inclusion complexes and their solutions in aqueous solvents, said compositions containing a) as an active ingredient a macrolide such as Rapamycin, Pimecrolimus, Temsirolimus, Everolimus or Tacrolimus in an amorphous form and optionally in the form of their polymorphic hydrates or solvates e.g. solvates formed with acetone or ethanol. b) a large surface cyclodextrin, such as gamma cyclodextrin—whereby the weight ratio of said macrolide to said cyclodextrin ranges between 1:111 and 1:333.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: October 27, 2015
    Assignee: EUTICALS SPA
    Inventors: Alberto Mangia, Paride Grisenti, Elisa Verza, Shahrzad Reza Elahi, Riccardo Monti
  • Chemo-enzymatic approach to the synthesis of pimecrolimus
    Patent number: 8778636
    Abstract: Processes for preparing pimecrolimus starting from ascomycin, exploiting the selectivity characteristics of the purified enzymatic systems particularly regarding the selective functionalization of the hydroxyl groups present in position 24 and 33 of ascomycin. Such method represents the first example of chemoenzymatic synthesis for preparing pimecrolimus.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: July 15, 2014
    Assignee: Euticals S.p.A.
    Inventors: Paride Grisenti, Shahrzad Reza Elahi, Elisa Verza
  • CHEMO-ENZYMATIC APPROACH TO THE SYNTHESIS OF PIMECROLIMUS
    Publication number: 20120064575
    Abstract: Processes for preparing pimecrolimus starting from ascomycin, exploiting the selectivity characteristics of the purified enzymatic systems particularly regarding the selective functionalization of the hydroxyl groups present in position 24 and 33 of ascomycin. Such method represents the first example of chemoenzymatic synthesis for preparing pimecrolimus.
    Type: Application
    Filed: May 19, 2010
    Publication date: March 15, 2012
    Inventors: Paride Grisenti, Shahrzad Reza Elahi, Elisa Verza
  • WATER-SOLUBLE SOLID PHARMACEUTICAL INCLUSION COMPLEXES AND THEIR AQUEOUS SOLUTIONS FOR ORAL, OPHTHALMIC, TOPICAL OR PARENTERAL USE CONTAINING A MACROLIDE AND CERTAIN CYCLODEXTRINS
    Publication number: 20120053198
    Abstract: This invention relates to new water-soluble solid pharmaceutical inclusion complexes and their aqueous solutions for oral, ophthalmic, topical or parenteral use containing a macrolide and certain cyclodextrins. More particularly the invention relates to new water-soluble solid pharmaceutical inclusion complexes and their solutions in aqueous solvents, said compositions containing a) as an active ingredient a macrolide such as Rapamycin, Pimecrolimus, Temsirolimus, Everolimus or Tacrolimus in an amorphous form and optionally in the form of their polymorphic hydrates or solvates e.g. solvates formed with acetone or ethanol. b) a large surface cyclodextrin, such as gamma cyclodextrin—whereby the weight ratio of said macrolide to said cyclodextrin ranges between 1:111 and 1:333.
    Type: Application
    Filed: June 29, 2011
    Publication date: March 1, 2012
    Applicant: EUTICALS SPA
    Inventors: Alberto Mangia, Paride Grisenti, Elisa Verza, Shahrzad Reza Elahi, Riccardo Monti
  • Process and new intermediates for the preparation of steroids with a progestogen activity
    Patent number: 7667056
    Abstract: The present invention relates to a new process of synthesis and to some new intermediates for the preparation of steroids with progestogen activity, more particularly, for the preparation of Desogestrel of formula (I). Said process is characterized by the regioselective reduction of the compound of formula (II) to give the intermediate of formula (III).
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: February 23, 2010
    Assignee: Poli Industria Chimica S.p.A.
    Inventors: Paride Grisenti, Fabio Pecora, Elisa Verza, Massimo Leoni, Laura Bossi
  • Process and new intermediates for the preparation of steroids with a progestogen activity
    Publication number: 20050234251
    Abstract: The present invention relates to a new process of synthesis and to some new intermediates for the preparation of steroids with progestogen activity, more particularly, for the preparation of Desogestrel of formula (1). Said process is characterized by the regioselective reduction of the compound of formula (II) to give the intermediate of formula (III).
    Type: Application
    Filed: July 31, 2003
    Publication date: October 20, 2005
    Applicant: Poli Industria Chemica SPA
    Inventors: Paride Grisenti, Fabio Pecora, Elisa Verza, Massimo Leoni, Laura Bossi