Patents by Inventor Elisabeth Adderson

Elisabeth Adderson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Group B Streptococcus Polypeptides Nucleic Acids and Therapeutic Compositions and Vaccines Thereof
    Publication number: 20130129737
    Abstract: This invention provides an isolated nucleic acid encoding a polypeptide comprising amino acid sequences of a streptococcal matrix adhesion E (EmaE) polypeptide. Antibodies to the EmaE polypeptide and immunogenic fragments thereof are also provided. This invention provides pharmaceutical compositions, immunogenic compositions, vaccines, and diagnostic and therapeutic methods of use of the isolated polypeptide, antibodies thereto, and nucleic acids.
    Type: Application
    Filed: February 18, 2011
    Publication date: May 23, 2013
    Applicants: University of Utah Research Foundation, St. Jude Children's Research Hospital
    Inventors: Elisabeth Adderson, John Bohnsack
  • Group B polypeptides nucleic acids and therapeutic compositions and vaccines thereof
    Patent number: 7892552
    Abstract: This invention provides isolated nucleic acids encoding polypeptides comprising amino acid sequences of streptococcal matrix adhesion (Ema) polypeptides. The invention provides nucleic acids encoding Group B streptococcal Ema polypeptides EmaA, EmaB, EmaC, EmaD and EmaE. The present invention provides isolated polypeptides comprising amino acid sequences of Group B streptococcal polypeptides EmaA, EmaB, EmaC, EmaD and EmaE, including analogs, variants, mutants, derivatives and fragments thereof. Ema homologous polypeptides from additional bacterial species, including S. pneumoniae, S. pyogenes, E. faecalis and C. diptheriae are also provided. Antibodies to the Ema polypeptides and immunogenic fragments thereof are also provided. The present invention relates to the identification and prevention of infections by virulent forms of streptococci.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: February 22, 2011
    Assignees: University of Utah Research Foundation, St. Jude Children's Research Hospital
    Inventors: Elisabeth Adderson, John Bohnsack
  • Group B Streptococcus Polypeptides Nucleic Acids and Therapeutic Compositions and Vaccines Thereof
    Publication number: 20100196379
    Abstract: This invention provides isolated nucleic acids encoding polypeptides comprising amino acid sequences of streptococcal matrix adhesion (Ema) polypeptides. The invention provides nucleic acids encoding Group B streptococcal Ema polypeptides EmaA, EmaB, EmaC, EmaD and EmaE. The present invention provides isolated polypeptides comprising amino acid sequences of Group B streptococcal polypeptides EmaA, EmaB, EmaC, EmaD and EmaE, including analogs, variants, mutants, derivatives and fragments thereof. Ema homologous polypeptides from additional bacterial species, including S. pneumoniae, S. pyogenes, E. faecalis and C. diptheriae are also provided. Antibodies to the Ema polypeptides and immunogenic fragments thereof are also provided. The present invention relates to the identification and prevention of infections by virulent forms of streptococci.
    Type: Application
    Filed: December 7, 2009
    Publication date: August 5, 2010
    Inventors: Elisabeth Adderson, John Bohnsack
  • Group B streptococcus polypeptides nucleic acids and therapeutic compositions and vaccines thereof
    Patent number: 7645577
    Abstract: This invention provides isolated nucleic acids encoding polypeptides comprising amino acid sequences of streptococcal matrix adhesion (Ema) polypeptides. The invention provides nucleic acids encoding Group B streptococcal Ema polypeptides EmaA, EmaB, EmaC, EmaD and EmaE. The present invention provides isolated polypeptides comprising amino acid sequences of Group B streptococcal polypeptides EmaA, EmaB, EmaC, EmaD and EmaE, including analogs, variants, mutants, derivatives and fragments thereof. Ema homologous polypeptides from additional bacterial species, including S. pneumoniae, S. pyogenes, E. faecalis and C. diptheriae are also provided. Antibodies to the Ema polypeptides and immunogenic fragments thereof are also provided. The present invention relates to the identification and prevention of infections by virulent forms of streptococci.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: January 12, 2010
    Assignees: St. Jude Children's Research Hospital, University of Utah Research Foundation
    Inventors: Elisabeth Adderson, John Bohnsack
  • Methods and Compositions for Diagnosing and Preventing a Group B Streptococcal Infection
    Publication number: 20080039386
    Abstract: The present invention provides a group B streptococcal (GBS) surface antigen, designated epsilon antigen, that is co-expressed with the delta antigen on a subset of serotype III GBS. Epsilon is expressed on more pathogenic Restriction Digest Pattern (RDP) III-3 GBS, but not on RDP types 1, 2, or 4. Accordingly, the present invention provides compositions and methods for detecting a group B streptococcus serotype III, RDP III-3 strain. Vaccines and methods of identifying agents which inhibit adhesion of a group B streptococcal cell to a host cell are also provided.
    Type: Application
    Filed: August 19, 2005
    Publication date: February 14, 2008
    Inventors: Linda Brady, Kyle Seifert, Elisabeth Adderson, John Bohnsack
  • Group B streptococcus polypeptides nucleic acids and therapeutic compositions and vaccines thereof
    Publication number: 20070178116
    Abstract: This invention provides isolated nucleic acids encoding polypeptides comprising amino acid sequences of streptococcal matrix adhesion (Ema) polypeptides. The invention provides nucleic acids encoding Group B streptococcal Ema polypeptides EmaA, EmaB, EmaC, EmaD and EmaE. The present invention provides isolated polypeptides comprising amino acid sequences of Group B streptococcal polypeptides EmaA, EmaB, EmaC, EmaD and EmaE, including analogs, variants, mutants, derivatives and fragments thereof. Ema homologous polypeptides from additional bacterial species, including S. pneumoniae, S. pyogenes, E. faecalis and C. diptheriae are also provided. Antibodies to the Ema polypeptides and immunogenic fragments thereof are also provided. The present invention relates to the identification and prevention of infections by virulent forms of streptococci.
    Type: Application
    Filed: July 26, 2006
    Publication date: August 2, 2007
    Inventors: Elisabeth Adderson, John Bohnsack
  • Group B streptococcus polypeptides nucleic acids and therapeutic compositions and vaccines thereof
    Patent number: 7128919
    Abstract: This invention provides isolated nucleic acids encoding polypeptides comprising amino acid sequences of streptococcal matrix adhesion (Ema) polypeptides. The invention provides nucleic acids encoding Group B streptococcal Ema polypeptides EmaA, EmaB, EmaC, EmaD and EmaE. The present invention provides isolated polypeptides comprising amino acid sequences of Group B streptococcal polypeptides EmaA, EmaB, EmaC, EmaD and EmaE, including analogs, variants, mutants, derivatives and fragments thereof. Ema homologous polypeptides from additional bacterial species, including S. pneumoniae, S. pyogenes, E. faecalis and C. diptheriae are also provided. Antibodies to the Ema polypeptides and immunogenic fragments thereof are also provided. The present invention relates to the identification and prevention of infections by virulent forms of streptococci.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: October 31, 2006
    Assignees: St. Jude Children's Research Hospital, University of Utah Research Foundation
    Inventors: Elisabeth Adderson, John Bohnsack
  • Group b streptococcus polypeptides nucleic acids and therapeutic compositions and vaccines thereof
    Publication number: 20040071729
    Abstract: This invention provides isolated nucleic acids encoding polypeptides comprising amino acid sequences of streptococcal matrix adhesion (Ema) polypeptides. The invention provides nucleic acids encoding Group B streptococcal Ema polypeptides EmaA, EmaB, EmaC, EmaD and EmaE. The present invention provides isolated polypeptides comprising amino acid sequences of Group B streptococcal polypeptides EmaA, EmaB, EmaC, EmaD and EmaE, including analogs, variants, mutants, derivatives and fragments thereof. Ema homologous polypeptides from additional bacterial species, including S. pneumoniae, S. pyogenes, E. faecalis and C. diptheriae are also provided. Antibodies to the Ema polypeptides and immunogenic fragments thereof are also provided. The present invention relates to the identification and prevention of infections by virulent forms of streptococci.
    Type: Application
    Filed: July 8, 2003
    Publication date: April 15, 2004
    Inventors: Elisabeth Adderson, John Bohnsack