Abstract: Multi-frequency Diffuse Photon Density Wave (DPDW) methodology at near infrared wavelengths is used to non-invasively measure the optical absorption and reduced scattering coefficients of tissue at depths of several millimeters to quantify the depth and degree of tissue damage. A digitally-controlled stepper motor and variable RF generator enable the user to select the distance between the light source and detector and the modulation frequency through software. This allows for the collection of virtually unlimited number of data points, enabling precise selection of the volume and depth of tissue that will be characterized.

Abstract: An apparatus and method for detecting an analyte are described. The apparatus includes at least one microchannel adapted for an analyte to adhere to an interior surface thereof, a mixing element positioned within at least a portion of the at least one microchannel, a light source for energizing quantum dots conjugated with the analyte within the at least one microchannel, and a detection system for detecting and quantifying fluorescent energy emitted by the quantum dots in one or more predetermined wavelength ranges, wherein each wavelength range being correlated to one and only one type of analyte.

Abstract: Provided is a method for immobilizing a macromolecule to a solid support material using poly(ethylene glycol), and a device obtained from the method. The macromolecule can be a polypeptide, such as an antibody.

Abstract: An apparatus and method for detecting an analyte are described. The apparatus includes at least one microchannel adapted for an analyte to adhere to an interior surface thereof, a mixing element positioned within at least a portion of the at least one microchannel, a light source for energizing quantum dots conjugated with the analyte within the at least one microchannel, and a detection system for detecting and quantifying fluorescent energy emitted by the quantum dots in one or more predetermined wavelength ranges, wherein each wavelength range being correlated to one and only one type of analyte.

Abstract: Methods for use of functionalized fluorescent nanoparticles in the non-destructive, direct and dynamic determination of free volume and glass transition changes and mechanical property changes of polymers and polymer composites are provided. Also provided are methods for use of functionalized fluorescent nanoparticles in tracking changes occurring in an individual component or components of a polymer composite. Methods for use of functionalized fluorescent nanoparticles in the quantitation and dynamic monitoring of crack propagation and fatigue of polymers and/or polymer composites and in the delivery of repair agents such as adhesives and/or cross-linking agents to cracks of polymers and polymer composites are provided.

Abstract: Methods and kits are provided for staining cell membranes using a biotinylated phospholipid in conjunction with streptavidin-coated quantum dots.

Abstract: A method for the treatment of chronic wounds in vertebrates, and compositions for use in the method, said compositions comprising synthetic antioxidants based on hindered piperidine or hindered phenol structures. The compositions optionally comprise carrier compounds that can include hydrogels.