Abstract: The present disclosure relates, in general, to therapeutic combinations, and to corresponding methods of treatment, pharmaceutical compositions, and kits.

Abstract: A pharmaceutical product for administration of an anti-HER2 antibody-drug conjugate in combination with a PARP1 selective inhibitor is provided. The anti-HER2 antibody drug conjugate is an antibody-drug conjugate in which a drug-linker represented by the following formula (wherein A represents the connecting position to an antibody) is conjugated to an anti-HER2 antibody via a thioether bond. Also provided is a therapeutic use and method wherein the antibody-drug conjugate and the PARP1 selective inhibitor are administered in combination to a subject: Formula (I).

Abstract: Provided are methods of treating cancer in a subject, comprising administering to the subject: i) an antibody-drug conjugate (ADC), ii) a cytotoxic agent and iii) an additional agent, wherein the additional agent is a PARP1 inhibitor or an ATR inhibitor or a pharmaceutically acceptable salt thereof. The present disclosure further provides kits comprising i) an antibody-drug conjugate (ADC), ii) a cytotoxic agent and iii) an additional agent, wherein the additional agent is a PARP1 inhibitor or an ATR inhibitor or a pharmaceutically acceptable salt thereof.

Abstract: Methods of treating cancer with a combination of a WEE1 inhibitor and a DNA-damaging agent in patients having SLFN11-deficient cancer cells are disclosed herein.

Abstract: A method and system for estimating the potential friction between a tire and a rolling surface in which: a first and second engaged-friction/kinematic-quantity reference curve respectively corresponding to a first and to a second reference value ??1, ?P2 of potential friction with ?P2>?P1 are provided; a first and a second kinematic quantity threshold value or a first and a second engaged friction threshold value are provided; the engaged friction ? between the tire and the rolling surface is determined; a current value of a kinematic quantity between the tire and the rolling surface is determined; a current working point given by the engaged friction ? and the current value of the kinematic quantity is determined; and the current value of the kinematic quantity is compared with the first and the second kinematic quantity threshold value or, respectively, the engaged friction ? is compared with the first and the second engaged friction threshold value.

Abstract: A method and system for estimating the potential friction between a tyre and a rolling surface in which: a first and second engaged-friction/kinematic-quantity reference curve respectively corresponding to a first and to a second reference value ??1, ?P2 of potential friction with ?P2>?P1 are provided; a first and a second kinematic quantity threshold value or a first and a second engaged friction threshold value are provided; the engaged friction ? between the tyre and the rolling surface is determined; a current value of a kinematic quantity between the tyre and the rolling surface is determined; a current working point given by the engaged friction ? and the current value of the kinematic quantity is determined; and the current value of the kinematic quantity is compared with the first and the second kinematic quantity threshold value or, respectively, the engaged friction ? is compared with the first and the second engaged friction threshold value.