Patents by Inventor Elise E. Drouin

Elise E. Drouin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of a T cell epitope of that induces T cell responses in patients with rheumatoid arthritis
    Patent number: 11982671
    Abstract: Disclosed herein are methods of diagnosing Rheumatoid arthritis in a subject comprising determining whether the subject is immunologically reactive with P. copri or a portion thereof. In one aspect of the invention the immunological reactivity of the subject to one or more protein of P. copri or polypeptide fragments thereof such as protein Pc-p27 or polypeptide fragments thereof, as compared to an appropriate control, indicates the subject has rheumatoid arthritis. Examples of specific assays, compositions, and kits for use with the methods are also disclosed.
    Type: Grant
    Filed: December 9, 2020
    Date of Patent: May 14, 2024
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Allen C. Steere, Elise E. Drouin
  • IDENTIFICATION OF A T CELL EPITOPE OF PREVOTELLA COPRI THAT INDUCES T CELL RESPONSES IN PATIENTS WITH REHUMATOID ARTHRITIS
    Publication number: 20210247391
    Abstract: Disclosed herein are methods of diagnosing Rheumatoid arthritis in a subject comprising determining whether the subject is immunologically reactive with P. copri or a portion thereof. In one aspect of the invention the immunological reactivity of the subject to one or more protein of P. copri or polypeptide fragments thereof such as protein Pc-p27 or polypeptide fragments thereof, as compared to an appropriate control, indicates the subject has rheumatoid arthritis. Examples of specific assays, compositions, and kits for use with the methods are also disclosed.
    Type: Application
    Filed: December 9, 2020
    Publication date: August 12, 2021
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Allen C. STEERE, Elise E. Drouin
  • Identification of a T cell epitope of that induces T cell responses in patients with Rheumatoid arthritis
    Patent number: 10908159
    Abstract: Disclosed herein are methods of diagnosing Rheumatoid arthritis in a subject comprising determining whether the subject is immunologically reactive with P. copri or a portion thereof. In one aspect of the invention the immunological reactivity of the subject to one or more protein of P. copri or polypeptide fragments thereof such as protein Pc-p27 or polypeptide fragments thereof, as compared to an appropriate control, indicates the subject has rheumatoid arthritis. Examples of specific assays and kits for use with the methods are also disclosed.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: February 2, 2021
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Allen C. Steere, Elise E. Drouin
  • Autoantigens for diagnosis of rheumatoid arthritis
    Patent number: 10429379
    Abstract: Disclosed herein are methods of diagnosing Rheumatoid arthritis in a subject comprising determining whether the subject is immunologically reactive with N-acetylglucosamine-6-sulfatase and/or filamin-A, wherein immunological reactivity of the subject to one or more of N-acetylglucosamine-6-sulfatase or filamin-A, as compared to an appropriate control, indicates the subject has rheumatoid arthritis. Examples of specific assays and kits for use with the methods are also disclosed.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: October 1, 2019
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Allen C. Steere, Elise E. Drouin
  • IDENTIFICATION OF A T CELL EPITOPE OF PREVOTELLA COPRI THAT INDUCES T CELL RESPONSES IN PATIENTS WITH RHEUMATOID ARTHRITIS
    Publication number: 20190137491
    Abstract: Disclosed herein are methods of diagnosing Rheumatoid arthritis in a subject comprising determining whether the subject is immunologically reactive with P. copri or a portion thereof. In one aspect of the invention the immunological reactivity of the subject to one or more protein of P. copri or polypeptide fragments thereof such as protein Pc-p27 or polypeptide fragments thereof, as compared to an appropriate control, indicates the subject has rheumatoid arthritis. Examples of specific assays and kits for use with the methods are also disclosed.
    Type: Application
    Filed: June 6, 2017
    Publication date: May 9, 2019
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Allen C. Steere, Elise E. Drouin
  • AUTOANTIGENS FOR DIAGNOSIS OF RHEUMATOID ARTHRITIS
    Publication number: 20180156778
    Abstract: Disclosed herein are methods of diagnosing Rheumatoid arthritis in a subject comprising determining whether the subject is immunologically reactive with N-acetylglucosamine-6-sulfatase and/or filamin-A, wherein immunological reactivity of the subject to one or more of N-acetylglucosamine-6-sulfatase or filamin-A, as compared to an appropriate control, indicates the subject has rheumatoid arthritis. Examples of specific assays and kits for use with the methods are also disclosed.
    Type: Application
    Filed: May 12, 2016
    Publication date: June 7, 2018
    Applicant: THE GENERAL HOSPITAL CORPORATION d/b/a MASSACHUSETTS GENERAL HOSPITAL
    Inventors: Allen C. Steere, Elise E. Drouin