Abstract: An active control containment system for defending an operator against biohazardous materials for use in medical, forensic and embalming procedures. The containment system has the advantage of being structurally simple, light weight and easily cleaned and maintained. The containment system includes a vaulted cover which together with an autopsy table forms a compartment within which the biohazardous material is contained. The autopsy table has a plurality of apertures through which a down-draft keeps the compartment at negative pressure as compared to the treatment room. An air intake is provided in the cover and an opening through which the operator can access the biohazardous material through the cover. Access doors are provided along the bottom of the cover for manipulation or transfer of materials.