Patents by Inventor Elisha P. Zeelon

Elisha P. Zeelon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptide having factor Xa inhibitory activity
    Patent number: 6211341
    Abstract: The present invention provides an antibody which specifically reacts with an epitope of a polypeptide comprising the amino acid sequence X-Y-CYS GLN GLU GLU GLU CYS PRO ASP PRO TYR LEU CYS SER PRO VAL THR ASN ARG CYS GLU CYS THR PRO VAL LEU CYS ARG MET TYR CYS LYS PHE TRP ALA LYS ASP GLU LYS GLY CYS GLU ILE CYS LYS CYS GLU GLU LEU CYS GLN ASN GLN ASN CYS THR LYS ASP MET LEU CYS SER SER VAL THR ASN ARG CYS ASP CYS GLN ASP PHE LYS CYS PRO GLN SER TYR CYS-Z (SEQ. ID NO. 1) wherein X is MET or absent; Y is 0-28 amino acids of the sequence LYS MET CYS TRP ASN LYS GLY CYS PRO CYS GLY GLN ARG CYS ASN LEU HIS ARG ASN GLU CYS GLU VAL ILE ALA GLU ASN ILE GLU, (SEQ. ID NO. 2) with the proviso that if part of the sequence is present, it is a carboxy-terminal part of the sequence including the carboxy-terminal GLU and wherein Val may be preceded by Gly; and Z is absent or all or a part of the sequence Pro110-Lys156 shown in FIG. 7 (SEQ. ID NO.
    Type: Grant
    Filed: January 11, 1999
    Date of Patent: April 3, 2001
    Assignee: Bio-Technology General Corp.
    Inventors: Elisha P. Zeelon, Moshe M. Werber, Avigdor Levanon
  • Polypeptide having factor Xa inhibitory method of reducing blood coagulation with a novel polypeptide having factor Xa inhibitory activity
    Patent number: 5863534
    Abstract: A novel polypeptide derived from the leech Hirudo medicinalis was found to be able to inhibit Factor Xa thereby reducing the extent of blood coagulation. The polypeptide is useful in treating conditions of excessive blood coagulation. A recombinant organism containing cDNA encoding the polypeptide has been deposited in the ATCC under Accession No. 69134. Recombinant microorganisms able to produce the polypeptide have been deposited in the ATCC under Accession Nos. 69135, 69137 and 69269.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 26, 1999
    Assignee: Bio-Technology General Corp.
    Inventors: Elisha P. Zeelon, Moshe M. Werber, Avigdor Levanon
  • Polypeptide having Factor Xa inhibitory activity
    Patent number: 5858970
    Abstract: A novel polypeptide derived from the leech Hirudo medicinalis was found to be able to inhibit Factor Xa thereby reducing the extent of blood coagulation. The polypeptide is useful in treating conditions of excessive blood coagulation. A recombinant organism containing cDNA encoding the polypeptide has been deposited in the ATCC under Accession No. 69134. Recombinant microorganisms able to produce the polypeptide have been deposited in the ATCC under Accession Nos. 69135, 69137 and 69269.
    Type: Grant
    Filed: January 7, 1997
    Date of Patent: January 12, 1999
    Assignee: Bio-Technology General Corp.
    Inventors: Elisha P. Zeelon, Moshe M. Werber, Avigdor Levanon
  • Method of treating of preventing influenza
    Patent number: 5824641
    Abstract: A novel polypeptide derived from the leech Hirudo medicinalis was found to be able to inhibit Factor Xa thereby reducing the extent of blood coagulation. The polypeptide is useful in treating conditions of excessive blood coagulation. A recombinant organism containing cDNA encoding the polypeptide has been deposited in the ATCC under Accession No. 69134. Recombinant microorganisms able to produce the polypeptide have been deposited in the ATCC under Accession Nos. 69135, 69137 and 69269.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 20, 1998
    Assignee: Bio-Technology General Corp
    Inventors: Elisha P. Zeelon, Moshe M. Werber, Avigdor Levanon
  • Production of recombinant factor Xa inhibitor of leech Hirudo medicinalis
    Patent number: 5801017
    Abstract: The present invention provides a recombinant polypeptide having the amino acid sequence X-tyr.sup.26 -gly.sup.110 where tyr.sup.26 -gly.sup.110 is identical to the sequence shown in FIG. 10, and wherein X is methionine or absent and wherein asn.sup.72 may be substituted by pro.The invention further provides a method of producing the polypeptide which comprises transforming a host cell with an expression plasmid encoding the polypeptide, culturing the transformed host cell so that the cell produces the polypeptide encoded by the plasmid, and a method of recovering the polypeptide so produced.
    Type: Grant
    Filed: April 8, 1994
    Date of Patent: September 1, 1998
    Assignee: Bio-Technology General Corp.
    Inventors: Moshe M. Werber, Elisha P. Zeelon, Avigdor Levanon, Rachel Guy, Arie Goldlust, Meir Rigbi, Amos Panet, Meir Fischer
  • DNA encoding novel polypeptide having Factor Xa inhibitory activity
    Patent number: 5783421
    Abstract: A novel polypeptide derived from the leech Hirudo medicinalis was found to be able to inhibit Factor Xa thereby reducing the extent of blood coagulation. The polypeptide is useful in treating conditions of excessive blood coagulation. A recombinant organism containing cDNA encoding the polypeptide has been deposited in the ATCC under Accession No. 69134. Recombinant microorganisms able to produce the polypeptide have been deposited in the ATCC under Accession Nos. 69135, 69137 and 69269.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 21, 1998
    Assignee: Bio-Technology General Corp.
    Inventors: Elisha P. Zeelon, Moshe M. Werber, Avigdor Levanon