Abstract: The invention provides means and methods for identifying a Streptococcus protein which is capable of eliciting an immune response against at least two Streptococcus strains and/or serotypes. The invention further discloses immunogenic compositions capable of eliciting an immune response against Streptococcus uberis comprising at least two recombinant and/or isolated proteins derived from Streptococcus uberis, and/or an immunogenic part or analogue or derivative of either or both proteins. The invention further discloses nucleic acid molecules encoding the proteins or immunogenic parts thereof, host cells and recombinant carriers comprising such nucleic acid molecule, and vaccines and diagnostic tests based on the proteins and nucleic acids.