Abstract: The current disclosure provides reinforced aerogel compositions that are durable and easy to handle, have favorable performance in aqueous environments, have favorable insulation properties, and have favorable, reaction to fire, combustion and flame-resistance properties. Also provided are methods of preparing or manufacturing such reinforced aerogel compositions. In certain embodiments, the composition has a silica-based aerogel framework, reinforced with an open-cell macroporous framework, and includes one or more fire-class additives, where the silica-based aerogel framework comprises at least one hydrophobic-bound silicon and the composition or each of its components has desired properties.

Abstract: An apparatus for the preparation of frozen confectionery products comprising a filling head (1) comprising one or more frozen confection inlets (3) connectable to a source of one or more frozen confections comprising one or more inclusions, a mixing chamber (4) and an outlet (2), a first housing (5) comprising a nozzle (6) is connectable to, and rotatable in relation to, the filling head outlet (2), and the outlet of the nozzle (7) has a cross section comprising a central section (8) and peripheral sections (9), wherein an annular shape (24) can be superimposed on the central section (8) and the diameter of the annular shape (24) has a ratio of from 3:1 to 6:1 of the longest length of the one or more inclusions, and the longest length of the one or more inclusions is from 2 mm to 10 mm. A process for the preparation of a frozen confection product comprising the foregoing apparatus and a product prepared according to the process.

Abstract: The present disclosure provides an aerogel composition which is intrinsically hydrophobic without surface modification by a hydrophobizing agent, is durable and easy to handle, which has favorable performance in aqueous environments, and which also has favorable combustion and self-heating properties. Also provided is a method of preparing an aerogel composition which is intrinsically hydrophobic without surface modification by a hydrophobizing agent, is durable and easy to handle, which has favorable performance in aqueous environments, and which has favorable combustion and self-heating properties.

Abstract: The present disclosure provides an aerogel composition which is intrinsically hydrophobic without surface modification by a hydrophobizing agent, is durable and easy to handle, which has favorable performance in aqueous environments, and which also has favorable combustion and self-heating properties. Also provided is a method of preparing an aerogel composition which is intrinsically hydrophobic without surface modification by a hydrophobizing agent, is durable and easy to handle, which has favorable performance in aqueous environments, and which has favorable combustion and self-heating properties.

Abstract: Disclosed are compositions and methods comprising the administration of pulsed dendritic cells and an immunoregulator molecule inhibitor for the treatment of cancer.

Abstract: Disclosed are combination therapies and methods for the treatment of Huntington's disease comprising the administration of a combination of a SEMA4D binding molecule and an HTT-lowering agent.

Abstract: Disclosed are compositions and methods comprising the administration of pulsed dendritic cells and an immunoregulator molecule inhibitor for the treatment of cancer.

Abstract: Provided herein are methods for selecting subjects having a neurodegenerative disorder for treatment with an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D), method for predicting the treatment outcome of subjects having a neurodegenerative disorder that are treated with an isolated binding molecule which specifically binds to SEMA4D and methods for treating subjects having a neurodegenerative disorder with an isolated binding molecule which specifically binds to SEMA4D.

Abstract: Disclosed herein is a cannula and/or medical instrument accessory configured for providing localized insufflation or venting of gases with respect to a surgical cavity of a patient (such as the pneumoperitoneum) and allowing insertion of medical instruments into the surgical cavity through the cannula. A medical instrument accessory such as a cannula and/or medical instrument accessory can be used for localizing insufflation or venting of gas or fluid near operating end of a medical instrument. The medical instrument accessory can comprise a body mountable over at least a portion of a medical instrument shaft, the body having an inner lumen, proximal end and distal end, the distal end comprising an opening, wherein the distal end is arranged in use at or adjacent an operating end of the medical instrument.

Abstract: This disclosure provides a method for inhibiting, delaying, or reducing malignant cell growth in a subject with cancer, comprising administering to the subject a combination therapy comprising an effective amount of an isolated antibody or antigen-binding fragment thereof that specifically binds to semaphorin-4D (SEMA4D) and an effective amount of an epigenetic modulating agent, e.g., a histone deacetylase (HDAC) inhibitor (HDACi) a DNA methyltransferase (DNMT) inhibitor (DNMTi), or any combination thereof. The disclosure further provides a pharmaceutical composition comprising the combination therapy.

Abstract: An apparatus for the preparation of frozen confectionery products comprising a filling head (1) comprising one or more frozen confection inlets (3) connectable to a source of one or more frozen confections comprising one or more inclusions, a mixing chamber (4) and an outlet (2), a first housing (5) comprising a nozzle (6) is connectable to, and rotatable in relation to, the filling head outlet (2), and the outlet of the nozzle (7) has a cross section comprising a central section (8) and peripheral sections (9), wherein an annular shape (24) can be superimposed on the central section (8) and the diameter of the annular shape (24) has a ratio of from 3:1 to 6:1 of the longest length of the one or more inclusions, and the longest length of the one or more inclusions is from 2 mm to 10 mm. A process for the preparation of a frozen confection product comprising the foregoing apparatus and a product prepared according to the process.

Abstract: A filter test kit for low vision is provided and may include a plurality of test frames. A test frame may include two sockets, a pair of optical lens tint components disposed in the sockets, a bridge connecting the sockets; and a tactile frame identifier. The pair of optical lens tint components for each frame is different from the pair of optical lens tint components of each other frame. Also, the tactile frame identifier for each frame is different from the tactile frame identifier for each other frame.

Abstract: Provided herein are methods for inhibiting, delaying, or reducing tumor growth and metastases of Plexin-B1-expressing cancer cells in a subject, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) in combination with an effective amount of at least one other immune modulating therapy.

Abstract: This disclosure provides a method for inhibiting, delaying, or reducing malignant cell growth in a subject with cancer, comprising administering to the subject a combination therapy comprising an effective amount of an isolated antibody or antigen-binding fragment thereof that specifically binds to semaphorin-4D (SEMA4D) and an effective amount of an epigenetic modulating agent, e.g., a histone deacetylase (HDAC) inhibitor (HDACi) a DNA methyltransferase (DNMT) inhibitor (DNMTi), or any combination thereof. The disclosure further provides a pharmaceutical composition comprising the combination therapy.

Abstract: A process for the manufacture of frozen gas hydrates, the process comprising passing a liquid aqueous phase over a heat exchanger surface under an atmosphere of a pressurised water-soluble gas, characterised in that the conditions of the process are selected to ensure that there is simultaneous dissolution of the pressurised gas into the liquid aqueous phase, and the formation of a solidified continuous phase from solidification of the liquid aqueous phase in contact with the heat exchanger surface.

Abstract: Disclosed are compositions and methods comprising the administration of pulsed dendritic cells and an immunoregulator molecule inhibitor for the treatment of cancer.

Abstract: The disclosure relates to methods for treating cancer comprising determining certain patient biomarker levels prior to treatment.

Abstract: Provided herein are methods for inhibiting, delaying, or reducing tumor growth and metastases of Plexin-B1-expressing cancer cells in a subject, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) in combination with an effective amount of at least one other immune modulating therapy.

Abstract: The present invention provides a process for the manufacture of frozen gas hydrates, the process comprising passing a liquid aqueous phase over a heat exchanger surface under an atmosphere of a pressurised water-soluble gas, characterised in that the conditions of the process are selected to ensure that there is simultaneous dissolution of the pressurised gas into the liquid aqueous phase, and the formation of a solidified continuous phase from solidification of the liquid aqueous phase in contact with the heat exchanger surface.

Abstract: The present invention relates to methods for the improved treatment of an inflammatory disorder, where the treatment comprises administration of sex-matched stem or progenitor cells, such as mesenchymal stem cells (MSCs), or sex-matched cell secretions, or a combination thereof to a subject. The invention also relates to kits and compositions which may be used in such methods.