Patents by Inventor Elizabeth A. Holmes

Elizabeth A. Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11119110
    Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 ?L) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: September 14, 2021
    Assignee: Labrador Diagnotics LLC
    Inventors: Mark Dayel, Samartha Anekal, Paul Patel, Ian Gibbons, Elizabeth A. Holmes
  • Patent number: 11112418
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: September 7, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Elizabeth A. Holmes, Daniel Young, Samartha Anekal, Chinmay Pangarkar
  • Publication number: 20210269859
    Abstract: Systems and methods for determining pathogens and antimicrobial resistance of pathogens in a sample are provided.
    Type: Application
    Filed: February 9, 2021
    Publication date: September 2, 2021
    Inventors: Elizabeth A. Holmes, Chandan Shee, Clarissa Lui
  • Publication number: 20210262940
    Abstract: The present invention provides methods of calibrating a fluidic device useful for detecting an analyte of interest in a bodily fluid. The invention also provides methods for assessing the reliability of an assay for an analyte in a bodily fluid with the use of a fluidic device. Another aspect of the invention is a method for performing a trend analysis on the concentration of an analyte in a subject using a fluidic device.
    Type: Application
    Filed: February 1, 2021
    Publication date: August 26, 2021
    Inventors: Ian Gibbons (deceased), Chengwang Wang, Shaunak Roy, Elizabeth A. Holmes
  • Patent number: 11092593
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: August 17, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
  • Publication number: 20210223163
    Abstract: The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.
    Type: Application
    Filed: December 28, 2020
    Publication date: July 22, 2021
    Applicant: Labrador Diagnostics LLC
    Inventors: Anthony J. NUGENT, Daniel L. YOUNG, Elizabeth A. HOLMES, Michael SIEGEL, Ryan WISTORT
  • Patent number: 11061022
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: July 13, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
  • Patent number: 11054432
    Abstract: Systems and methods are provided for sample processing. The system, in one configuration, includes a sample processing apparatus for use with a biological sample and/or a reagent, a housing and a touchscreen display mounted to the housing. The system, in one configuration, contains a cartridge insertion location; at least one optical detector; a control unit having a processor that is programmed to execute computer-readable commands; and a sample handling system.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: July 6, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Elizabeth A. Holmes, Joy Roy, Peter Kardassakis
  • Patent number: 11046992
    Abstract: Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: June 29, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Alexander Loo, Elizabeth A. Holmes
  • Publication number: 20210186393
    Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.
    Type: Application
    Filed: December 4, 2020
    Publication date: June 24, 2021
    Inventors: Patricia McHale, Michael Chen, Pey-Jiun Ko, Tammy Burd, Adrit Lath, Elizabeth A. Holmes, Joy Roy
  • Publication number: 20210156848
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Application
    Filed: February 2, 2021
    Publication date: May 27, 2021
    Inventors: Tammy BURD, Ian GIBBONS, Elizabeth A. HOLMES, Gary FRENZEL, Anthony Joseph NUGENT
  • Publication number: 20210145337
    Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.
    Type: Application
    Filed: November 20, 2020
    Publication date: May 20, 2021
    Inventors: Elizabeth A. Holmes, Michael Chen, Pey-Jiun Ko, Tammy Burd, Adrit Lath, Patricia McHale
  • Patent number: 11008628
    Abstract: In one embodiment, a method is provided comprising analyte testing on one or more types of samples.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: May 18, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Elizabeth A. Holmes, Timothy Smith, Samartha Anekal, James R. Wasson, Daniel L. Young, Chinmay Pangarkar
  • Patent number: 11009516
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: May 18, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Elizabeth A. Holmes, Michael Chen, Pey-Jiun Ko
  • Publication number: 20210140866
    Abstract: Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.
    Type: Application
    Filed: September 22, 2020
    Publication date: May 13, 2021
    Inventors: Mark Dayel, Samartha Anekal, Elizabeth A. Holmes
  • Patent number: 10989724
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: April 27, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Elizabeth A. Holmes, Daniel Young, Samartha Anekal, Timothy Smith, James R. Wasson, Chinmay Pangarkar
  • Publication number: 20210115496
    Abstract: Methods, devices, systems, and kits for use in detecting and measuring infectious diseases are provided. In particular embodiments, methods, devices, systems, and kits for detecting and measuring Ebola virus, including Ebola Zaire strain virus, are provided. Devices and systems may be used within regions suffering from Ebola or other infections, providing local, rapid, and effective diagnosis of infectious diseases such as Ebola, improving treatment and reducing or preventing spread of such infectious diseases.
    Type: Application
    Filed: October 9, 2020
    Publication date: April 22, 2021
    Inventors: Daniel Young, Elizabeth A. Holmes
  • Patent number: 10976330
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: April 13, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Elizabeth A. Holmes, Joy Roy, Peter Kardassakis, Sunny Balwani
  • Patent number: 10943689
    Abstract: In one embodiment, a method is provided comprising displaying a laboratory test menu on a mobile computing device, where the test menu is variable-based on geographic location; selecting one or more tests from said test menu; and using the mobile computing device to send a laboratory test request to a server.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: March 9, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Elizabeth A. Holmes, Sunny Balwani
  • Publication number: 20210055226
    Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.
    Type: Application
    Filed: August 31, 2020
    Publication date: February 25, 2021
    Inventors: Elizabeth A. Holmes, Ian Gibbons, Timothy K. Kemp, John Howard, Shaunak Roy