Patents by Inventor Elizabeth A. Holmes

Elizabeth A. Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180308585
    Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.
    Type: Application
    Filed: April 13, 2018
    Publication date: October 25, 2018
    Applicant: Theranos IP Company, LLC
    Inventors: Elizabeth A. HOLMES, Ian GIBBONS, Daniel YOUNG, Seth G. MICHELSON
  • Publication number: 20180238864
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Application
    Filed: April 13, 2018
    Publication date: August 23, 2018
    Inventors: Tammy BURD, Ian GIBBONS, Elizabeth A. HOLMES, Gary FRENZEL, Anthony Joseph NUGENT
  • Publication number: 20180231533
    Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.
    Type: Application
    Filed: April 12, 2018
    Publication date: August 16, 2018
    Inventors: Elizabeth A. HOLMES, Shaunak Roy, Ian Gibbons, Shize Daniel Qi, Edmond Ku, Chris Todd, Melissa Takahashi, Bruce Johnson, Jeff Fenton, Keith Moravick, Uwe Springborn, Anthony Delacruz
  • Publication number: 20180231469
    Abstract: The present invention provides methods of calibrating a fluidic device useful for detecting an analyte of interest in a bodily fluid. The invention also provides methods for assessing the reliability of an assay for an analyte in a bodily fluid with the use of a fluidic device. Another aspect of the invention is a method for performing a trend analysis on the concentration of an analyte in a subject using a fluidic device.
    Type: Application
    Filed: April 12, 2018
    Publication date: August 16, 2018
    Inventors: Ian GIBBONS, Chengwang WANG, Shaunak Roy, Elizabeth A. Holmes
  • Publication number: 20180231536
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Application
    Filed: April 13, 2018
    Publication date: August 16, 2018
    Inventors: Tammy BURD, Ian GIBBONS, Elizabeth A. HOLMES, Gary FRENZEL, Anthony Joseph NUGENT
  • Publication number: 20180224472
    Abstract: Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.
    Type: Application
    Filed: January 8, 2018
    Publication date: August 9, 2018
    Inventors: Alexander Loo, Elizabeth A. Holmes
  • Publication number: 20180214058
    Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.
    Type: Application
    Filed: December 21, 2017
    Publication date: August 2, 2018
    Inventors: Elizabeth A. Holmes, Michael Chen, Pey-Jiun Ko, Tammy Burd, Adrit Lath, Patricia McHale
  • Publication number: 20180209976
    Abstract: The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection in a sample of bodily fluid.
    Type: Application
    Filed: January 8, 2018
    Publication date: July 26, 2018
    Inventors: Elizabeth A. Holmes, Ian Gibbons
  • Patent number: 10018549
    Abstract: Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: July 10, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Mark Dayel, Samartha Anekal, Elizabeth A. Holmes
  • Patent number: 10018643
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: July 10, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Elizabeth A. Holmes, Chinmay Pangarkar, Samartha Anekal, John K. Frankovich, Michael Chen, Timothy Smith
  • Patent number: 10012664
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: July 3, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: James Wasson, John Kent Frankovich, Elizabeth A. Holmes, Timothy Smith, Michael Chen, Daniel Young
  • Patent number: 10012638
    Abstract: Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: July 3, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Mark Dayel, Samartha Anekal, Elizabeth A. Holmes
  • Patent number: 9952240
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: April 24, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Elizabeth A. Holmes, Michael Chen, Pey-Jiun Ko
  • Publication number: 20180089827
    Abstract: Systems and methods are provided for collecting, preparing, and/or analyzing a biological sample. A sample collection site may be utilized with one or more sample processing device. The sample processing device may be configured to accept a sample from a subject. The sample processing device may perform one or more sample preparation step and/or chemical reaction involving the sample. Data related to the sample may be sent from the device to a laboratory. The laboratory may be a certified laboratory that may generate a report that is transmitted to a health care professional. The health care professional may rely on the report for diagnosing, treating, and/or preventing a disease in the subject.
    Type: Application
    Filed: September 29, 2017
    Publication date: March 29, 2018
    Inventor: Elizabeth A. Holmes
  • Patent number: 9908113
    Abstract: Methods and devices are provided for sample collection and sample separation. In one embodiment, a device is provided for use with a formed component liquid sample, the device comprising at least one sample inlet for receiving said sample; at least a first outlet for outputting only a liquid portion of the formed component liquid sample; at least a second outlet for outputting the formed component liquid sample at least a first material mixed therein.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: March 6, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Deborah Sloan, Elizabeth A. Holmes, Pey-Jiun Ko, Edwina Lai
  • Publication number: 20180045745
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Application
    Filed: April 25, 2017
    Publication date: February 15, 2018
    Inventors: Elizabeth A. Holmes, Joy Roy
  • Patent number: 9885729
    Abstract: Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: February 6, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Alexander Loo, Elizabeth A. Holmes
  • Patent number: 9885715
    Abstract: The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection in a sample of bodily fluid.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: February 6, 2018
    Assignee: Theranos IP Comany, LLC
    Inventors: Elizabeth A. Holmes, Ian Gibbons
  • Patent number: 9877674
    Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: January 30, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Elizabeth A. Holmes, Michael Chen, Pey-Jiun Ko, Tammy Burd, Adrit Lath, Patricia McHale
  • Publication number: 20180020823
    Abstract: Methods for obtaining a sample from a subject include providing a sample collection room within a retail store or physician's office; and obtaining a sample. Methods for analyzing a sample include providing a sample collection room within a retail store or physician's office; obtaining a sample; and analyzing it. A waiting room; a bathroom; and a pass-through from bathroom to sample collection room may be provided. Sample collection rooms may include a warming table; a warming plate; a finger warmer; a fingertip warmer; an air-warmer; a reclining chair; a calming feature; and adjustable lighting. Samples may be analyzed at the collection location or sent to elsewhere for analysis. Sample collection rooms may house a sample analysis device or system. Samples may be small, e.g., a finger-stick, and may be analyzed in a short period of time, e.g., in less than five hours, or less than four hours.
    Type: Application
    Filed: April 5, 2017
    Publication date: January 25, 2018
    Inventors: Elizabeth A. Holmes, Jeffrey Blickman, Nicholas Menchel