Patents by Inventor Elizabeth A. Holmes

Elizabeth A. Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10244973
    Abstract: Bodily fluid sample transport systems, devices, and method are provided. In at least one embodiment described herein, methods are provided for the physical transport of small volumes of bodily fluid in liquid form from one location to another location. By way of nonlimiting example, the samples are collected in liquid form at a collection site, transported in liquid form, and arrive at an analysis site in liquid form. In many embodiments, the liquid form during transport is not held in a porous matrix, wicking material, webbing, or similar material that prevents sample for being extracted in liquid form at the destination site. In one embodiment, small volume of sample in each sample vessel is in the range of about 1 ml to about 1 microliter.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: April 2, 2019
    Assignee: Theranos IP Company, LLC
    Inventors: Elizabeth A. Holmes, Clarissa Lui, Michael Chen, Daniel Young
  • Patent number: 10248765
    Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample vessel for receiving the bodily fluid sample collected in the sample collection channel, the sample vessel operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the vessel and/or another source provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the vessel.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: April 2, 2019
    Assignee: Theranos IP Company, LLC
    Inventors: Elizabeth A. Holmes, Clarissa Lui, Michael Chen, Daniel Young, Adrit Lath, Zachary Morrison, Brian Argyres, William Westrick
  • Patent number: 10233479
    Abstract: Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: March 19, 2019
    Assignee: Theranos IP Company, LLC
    Inventors: Alexander Loo, Elizabeth A. Holmes
  • Patent number: 10233480
    Abstract: Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: March 19, 2019
    Assignee: Theranos IP Company, LLC
    Inventors: Alexander Loo, Elizabeth A. Holmes
  • Patent number: 10222310
    Abstract: Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: March 5, 2019
    Assignee: Theranos IP Company, LLC
    Inventors: Mark Dayel, Samartha Anekal, Elizabeth A. Holmes
  • Patent number: 10181120
    Abstract: An illustrative embodiment disclosed herein is an EMV certification system including a credit card simulator configured to program a probe with credit card data, a point of sale simulator configured to send transaction data to a payment terminal, a robotic arm configured to perform an action on the payment terminal, and a robot controller communicatively coupled to the robotic arm. The robot controller is configured to instruct the robotic arm to perform the action. The EMV certification system further includes a test coordinator communicatively coupled to the credit card simulator, the point of sale simulator, and the robot controller. The test coordinator is configured to request the robot controller instruct the robotic arm based on reading a response from the payment terminal.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: January 15, 2019
    Assignee: U.S. Bancorp, National Association
    Inventors: Elizabeth Holmes, Utthej Nukala, Jose Rivera, Terron Hyde, James Cantrell
  • Publication number: 20180374582
    Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.
    Type: Application
    Filed: April 13, 2018
    Publication date: December 27, 2018
    Applicant: Theranos IP Company, LLC
    Inventors: Elizabeth A. HOLMES, Ian GIBBONS, Daniel YOUNG, Seth G. MICHELSON
  • Patent number: 10130283
    Abstract: The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: November 20, 2018
    Assignee: Theranos, IP Company, LLC
    Inventors: Elizabeth A. Holmes, Shaunak Roy, John Howard, Chengwang Wang
  • Publication number: 20180308585
    Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.
    Type: Application
    Filed: April 13, 2018
    Publication date: October 25, 2018
    Applicant: Theranos IP Company, LLC
    Inventors: Elizabeth A. HOLMES, Ian GIBBONS, Daniel YOUNG, Seth G. MICHELSON
  • Publication number: 20180238864
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Application
    Filed: April 13, 2018
    Publication date: August 23, 2018
    Inventors: Tammy BURD, Ian GIBBONS, Elizabeth A. HOLMES, Gary FRENZEL, Anthony Joseph NUGENT
  • Publication number: 20180231533
    Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.
    Type: Application
    Filed: April 12, 2018
    Publication date: August 16, 2018
    Inventors: Elizabeth A. HOLMES, Shaunak Roy, Ian Gibbons, Shize Daniel Qi, Edmond Ku, Chris Todd, Melissa Takahashi, Bruce Johnson, Jeff Fenton, Keith Moravick, Uwe Springborn, Anthony Delacruz
  • Publication number: 20180231536
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Application
    Filed: April 13, 2018
    Publication date: August 16, 2018
    Inventors: Tammy BURD, Ian GIBBONS, Elizabeth A. HOLMES, Gary FRENZEL, Anthony Joseph NUGENT
  • Publication number: 20180231469
    Abstract: The present invention provides methods of calibrating a fluidic device useful for detecting an analyte of interest in a bodily fluid. The invention also provides methods for assessing the reliability of an assay for an analyte in a bodily fluid with the use of a fluidic device. Another aspect of the invention is a method for performing a trend analysis on the concentration of an analyte in a subject using a fluidic device.
    Type: Application
    Filed: April 12, 2018
    Publication date: August 16, 2018
    Inventors: Ian GIBBONS, Chengwang WANG, Shaunak Roy, Elizabeth A. Holmes
  • Publication number: 20180224472
    Abstract: Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.
    Type: Application
    Filed: January 8, 2018
    Publication date: August 9, 2018
    Inventors: Alexander Loo, Elizabeth A. Holmes
  • Publication number: 20180214058
    Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.
    Type: Application
    Filed: December 21, 2017
    Publication date: August 2, 2018
    Inventors: Elizabeth A. Holmes, Michael Chen, Pey-Jiun Ko, Tammy Burd, Adrit Lath, Patricia McHale
  • Publication number: 20180209976
    Abstract: The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection in a sample of bodily fluid.
    Type: Application
    Filed: January 8, 2018
    Publication date: July 26, 2018
    Inventors: Elizabeth A. Holmes, Ian Gibbons
  • Patent number: 10018643
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: July 10, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Elizabeth A. Holmes, Chinmay Pangarkar, Samartha Anekal, John K. Frankovich, Michael Chen, Timothy Smith
  • Patent number: 10018549
    Abstract: Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: July 10, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Mark Dayel, Samartha Anekal, Elizabeth A. Holmes
  • Patent number: 10012638
    Abstract: Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: July 3, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Mark Dayel, Samartha Anekal, Elizabeth A. Holmes
  • Patent number: 10012664
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: July 3, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: James Wasson, John Kent Frankovich, Elizabeth A. Holmes, Timothy Smith, Michael Chen, Daniel Young