Abstract: Cyclic peptides that are proteasome stimulators, compositions comprising the same, and their use for stimulating proteasomal degradation of proteins.

Abstract: According to aspects of the disclosure, a display system is provided comprising a support, a first display coupled to the support, wherein the first display is configured to display output information received from at least one computing device, and a second display rotatably coupled to the first display and rotatably coupled to the support, wherein the second display is configured to display output information received from the at least one computing device.

Abstract: Methods, systems, and computer storage media for providing generative artificial intelligence (AI) personalization management using a generative AI personalization engine in an item listing system. A generative AI personalization engine supports generative AI personalization management based on an automotive personalization platform including personalization training operations, personalization operations, and personalization interfaces associated with a generative AI model and an automotive domain. The generative AI personalization engine provides generative AI personalization engine operations to improve personalization and presentation of automotive-related data in an item listing system. In operation, a request associated with a user is accessed. Based on the request, automotive personalization data associated with a generative AI model is accessed.

Abstract: Disclosed herein are systems and methods for a method for controlling the temperature of a surface. In some embodiments, the method includes applying a variable input to a heat pump (e.g., a Peltier) in thermal communication with the surface. The variable input may vary about a voltage and may include a powered period and an unpowered period. In some embodiments, the method includes measuring a temperature of an element in thermal communication with the surface, determining, based on the temperature of the element, whether a temperature of the surface is within a safe temperature range for a user in thermal communication with the surface, in response to determining the surface is not within the safe temperature range, adjusting the voltage of the variable input to the heat pump, and in response to determining the surface is within the safe temperature range, continuing operation of the variable input at the voltage.

Abstract: Disclosed herein are systems and methods for a method for controlling the temperature of a surface. In some embodiments, the method includes applying a variable input to a heat pump (e.g., a Peltier) in thermal communication with the surface. The variable input may vary about a voltage and may include a powered period and an unpowered period. In some embodiments, the method includes measuring a temperature of an element in thermal communication with the surface, determining, based on the temperature of the element, whether a temperature of the surface is within a safe temperature range for a user in thermal communication with the surface, in response to determining the surface is not within the safe temperature range, adjusting the voltage of the variable input to the heat pump, and in response to determining the surface is within the safe temperature range, continuing operation of the variable input at the voltage.

Abstract: Disclosed herein are systems and methods for a method for controlling the temperature of a surface. In some embodiments, the method includes applying a variable input to a heat pump (e.g., a Peltier) in thermal communication with the surface. The variable input may vary about a voltage and may include a powered period and an unpowered period. In some embodiments, the method includes measuring a temperature of an element in thermal communication with the surface, determining, based on the temperature of the element, whether a temperature of the surface is within a safe temperature range for a user in thermal communication with the surface, in response to determining the surface is not within the safe temperature range, adjusting the voltage of the variable input to the heat pump, and in response to determining the surface is within the safe temperature range, continuing operation of the variable input at the voltage.

Abstract: Disclosed herein are systems and methods for a method for controlling the temperature of a surface. In some embodiments, the method includes applying a variable input to a heat pump (e.g., a Peltier) in thermal communication with the surface. The variable input may vary about a voltage and may include a powered period and an unpowered period. In some embodiments, the method includes measuring a temperature of an element in thermal communication with the surface, determining, based on the temperature of the element, whether a temperature of the surface is within a safe temperature range for a user in thermal communication with the surface, in response to determining the surface is not within the safe temperature range, adjusting the voltage of the variable input to the heat pump, and in response to determining the surface is within the safe temperature range, continuing operation of the variable input at the voltage.

Abstract: Disclosed herein is a method of preparing a pharmaceutical formulation comprising a preservative, a surfactant and an anti-TFPI antibody (concizumab) as the active pharmaceutical ingredient. Application of the disclosed method results in the pharmaceutical formulation having improved chemical and physical purity. Also disclosed herein is the pharmaceutical formulation obtained using said method and its medical uses.

Abstract: Disclosed herein are methods of treating Rett syndrome comprising administering trofinetide to a subject in need thereof in which a dosage is provided that may reduce or avoid underexposure, e.g., in low body weight subjects, and/or provide other benefits.

Abstract: A server is programmed to predict high burden behavioral health insurance plan participants. The server receives health data from several data sources. The data is associated with the insurance plan participants. The server develops data variables and risk metrics relating to behavioral health of the participants. Sample data is collected from the health data. The sample data includes a first sample data set including a plurality of first values relating to the plurality of data variables, and a second sample data set including a plurality of second values relating to the plurality of risk metrics. The server analyzes the first and second sample data sets to determine one or more correlations between the first values and the second values. The server configures a software model to implement the correlations to predict which of the participants are at risk of becoming burden behavioral health insurance plan participants.

Abstract: Dilute nitride optical absorber materials having graded doping profiles are disclosed. The materials can be used in photodetectors and photovoltaic cells. Dilute nitride subcells having graded doping display improved efficiency, short circuit current density, and open circuit voltage.

Abstract: A lattice-matched solar cell having a dilute nitride-based sub-cell has exponential doping to thereby control current-carrying capacity of the solar cell. Specifically a solar cell with at least one dilute nitride sub-cell that has a variably doped base or emitter is disclosed. In one embodiment, a lattice matched multi junction solar cell has an upper sub-cell, a middle sub-cell and a lower dilute nitride sub-cell, the lower dilute nitride sub-cell having doping in the base and/or the emitter that is at least partially exponentially doped so as to improve its solar cell performance characteristics. In construction, the dilute nitride sub-cell may have the lowest bandgap and be lattice matched to a substrate, the middle cell typically has a higher bandgap than the dilute nitride sub-cell while it is lattice matched to the dilute nitride sub-cell.

Abstract: A sensing catheter having an outer flexible sheath and a distal section containing a sensing system having a sensing means, a radiant energy providing means and radiation transmitting means, preferably all housed within a fluid channel.

Abstract: Compound semiconductor alloys comprising dilute nitride materials, are materials used in absorbing layers for photodetectors, power converters, solar cells, and in particular to high efficiency, electronic and optoelectronic devices, including multijunction solar cells, photodetectors, power converters, and the like, formed primarily of III-V semiconductor alloys. The absorbing (or active) layers achieve improved characteristics including band gap optimization and minimization of defects.

Abstract: Multijunction solar cells having at least four subcells are disclosed, in which at least one of the subcells comprises a base layer formed of an alloy of one or more elements from group III on the periodic table, nitrogen, arsenic, and at least one element selected from the group consisting of Sb and Bi, and each of the subcells is substantially lattice matched. Methods of manufacturing solar cells and photovoltaic systems comprising at least one of the multijunction solar cells are also disclosed.

Abstract: An alloy composition for a subcell of a solar cell is provided that has a bandgap of at least 0.9 eV, namely, Ga1-xInxNyAs1-y-zSbz with a low antimony (Sb) content and with enhanced indium (In) content and enhanced nitrogen (N) content, achieving substantial lattice matching to GaAs and Ge substrates and providing both high short circuit currents and high open circuit voltages in GaInNAsSb subcells for multijunction solar cells. The composition ranges for Ga1-xInxNyAs1-y-zSbz are 0.07?x?0.18, 0.025?y?0.04 and 0.001?z?0.03.

Abstract: A method of preparing and serving a sandwich involves providing a ring, providing a pita, opening the pita to expose a pocket, placing the pita into the ring, filling the pocket with foodstuffs, and serving the assembled sandwich, in the ring, to a diner.

Abstract: Dilute nitride subcells with graded doping are disclosed. Dilute nitride subcells having graded doping display improved efficiency, short circuit current density, and open circuit voltage.

Abstract: A process for revitalization of the coal deposit for enhanced microbial gas production by exposing coal deposit to air oxidation. Water is removed from coal beds and stored. The coal is exposed to hydrogen peroxide for providing oxygen-rich organic molecules that are more readily biodegraded. Oxidation and drying out of coal produces additional cracks within the coal matrix to allow microbes greater access to the overall coal matrix. The coal is reinjected with emulsified oil and inorganic nutrients by transporting produced water from the storage sites to the reinjection wells. Produced water is mixed with oil and inorganic nutrients in a holding tank. The reinjection water containing nutrients and oil is then injected into the coal under pressure. The mixture presence of the oil speeds up cell division of bacteria and methanogens in the coal and create microbial biomass sufficient to accelerate biomethanogenesis of the coal.