Patents by Inventor Elizabeth A. MANRAO

Elizabeth A. MANRAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for generating reference maps for nanopore-based polymer analysis
    Patent number: 11959133
    Abstract: The present disclosure generally relates to the methods and compositions to efficiently analyze polymer characteristics using nanopore-based assays. Specifically disclosed is a method for generating reference signals for polymer analysis in a nanopore system, wherein the nanopore system has a multi-subunit output signal resolution. The method comprises translocating a reference sequence through a nanopore to generate a plurality of reference output signals, wherein each possible multi-subunit sequence that can determine an output signal appears only once in the reference sequence. The output signals are compiled into a reference map for nanopore analysis of an analyte polymer. Also provided are methods and compositions for calibrating the nanopore system for optimized polymer analysis.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: April 16, 2024
    Assignee: University of Washington Through Its Center for Commercialization
    Inventors: Jens Gundlach, Ian M. Derrington, Andrew Laszlo, Elizabeth Manrao
  • CHEMICAL COMPOSITIONS AND METHODS OF USING SAME
    Publication number: 20240084361
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Application
    Filed: September 21, 2023
    Publication date: March 14, 2024
    Inventors: Dwayne L. DUNAWAY, Elizabeth A. MANRAO, Joseph M. BEECHEM, Rustem KHAFIZOV, Sanghamithra KORUKONDA, Yi DENG, Dae KIM, Mark GREGORY, Margaret HOANG
  • Chemical compositions and methods of using same
    Patent number: 11821026
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Grant
    Filed: March 7, 2023
    Date of Patent: November 21, 2023
    Assignee: NanoString Technologies, Inc.
    Inventors: Dwayne L. Dunaway, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang
  • CHEMICAL COMPOSITIONS AND METHODS OF USING SAME
    Publication number: 20230257800
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Application
    Filed: March 7, 2023
    Publication date: August 17, 2023
    Inventors: Dwayne L. DUNAWAY, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang
  • CHEMICAL COMPOSITIONS AND METHODS OF USING SAME
    Publication number: 20230220461
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Application
    Filed: December 21, 2022
    Publication date: July 13, 2023
    Inventors: Dwayne DUNAWAY, Elizabeth A. MANRAO, Joseph M. BEECHEM, Rustem KHAFIZOV, Sanghamithra KORUKONDA, Yi DENG, Dae KIM, Mark GREGORY, Margaret HOANG, Matthew WALSH, Gavin MEREDITH, Mark MCELWAIN, Peter SKENE, Cassandra Burke
  • Chemical compositions and methods of using same
    Patent number: 11549139
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: January 10, 2023
    Assignee: NanoString Technologies, Inc.
    Inventors: Dwayne Dunaway, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang, Matthew Walsh, Gavin Meredith, Mark McElwain, Peter Skene, Cassandra Burke
  • CHEMICAL COMPOSITIONS AND METHODS OF USING SAME
    Publication number: 20220213532
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Application
    Filed: March 21, 2022
    Publication date: July 7, 2022
    Inventors: Dwayne L. DUNAWAY, Elizabeth A. MANRAO, Joseph M. BEECHEM, Rustem KHAFIZOV, Sanghamithra KORUKONDA, Yi DENG, Dae KIM, Mark GREGORY, Margaret HOANG
  • Chemical compositions and methods of using same
    Patent number: 11279969
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: March 22, 2022
    Assignee: NanoString Technologies, Inc.
    Inventors: Dwayne L. Dunaway, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang
  • METHODS AND COMPOSITIONS FOR GENERATING REFERENCE MAPS FOR NANOPORE-BASED POLYMER ANALYSIS
    Publication number: 20200377936
    Abstract: The present disclosure generally relates to the methods and compositions to efficiently analyze polymer characteristics using nanopore-based assays. Specifically disclosed is a method for generating reference signals for polymer analysis in a nanopore system, wherein the nanopore system has a multi-subunit output signal resolution. The method comprises translocating a reference sequence through a nanopore to generate a plurality of reference output signals, wherein each possible multi-subunit sequence that can determine an output signal appears only once in the reference sequence. The output signals are compiled into a reference map for nanopore analysis of an analyte polymer. Also provided are methods and compositions for calibrating the nanopore system for optimized polymer analysis.
    Type: Application
    Filed: March 19, 2020
    Publication date: December 3, 2020
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Jens Gundlach, Ian M. Derrington, Andrew Laszlo, Elizabeth Manrao
  • Methods and compositions for generating reference maps for nanopore-based polymer analysis
    Patent number: 10612083
    Abstract: The present disclosure generally relates to the methods and compositions to efficiently analyze polymer characteristics using nanopore-based assays. Specifically disclosed is a method for generating reference signals for polymer analysis in a nanopore system, wherein the nanopore system has a multi-subunit output signal resolution. The method comprises translocating a reference sequence through a nanopore to generate a plurality of reference output signals, wherein each possible multi-subunit sequence that can determine an output signal appears only once in the reference sequence. The output signals are compiled into a reference map for nanopore analysis of an analyte polymer. Also provided are methods and compositions for calibrating the nanopore system for optimized polymer analysis.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: April 7, 2020
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Jens Gundlach, Ian M. Derrington, Andrew Laszlo, Elizabeth Manrao
  • CHEMICAL COMPOSITIONS AND METHODS OF USING SAME
    Publication number: 20190390258
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Application
    Filed: September 4, 2019
    Publication date: December 26, 2019
    Inventors: Dwayne L. DUNAWAY, Elizabeth A. MANRAO, Joseph M. BEECHEM, Rustem KHAFIZOV, Sanghamithra KORUKONDA, Yi DENG, Dae KIM, Mark GREGORY, Margaret HOANG
  • CHEMICAL COMPOSITIONS AND METHODS OF USING SAME
    Publication number: 20190345548
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Application
    Filed: May 14, 2019
    Publication date: November 14, 2019
    Inventors: Dwayne DUNAWAY, Elizabeth A. MANRAO, Joseph M. BEECHEM, Rustem KHAFIZOV, Sanghamithra KORUKONDA, Yi DENG, Dae KIM, Mark GREGORY, Margaret HOANG, Matthew WALSH, Gavin MEREDITH, Mark MCELWAIN, Peter Skene, Cassandra Burke
  • Chemical compositions and methods of using same
    Patent number: 10415080
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: September 17, 2019
    Assignee: NanoString Technologies, Inc.
    Inventors: Dwayne L. Dunaway, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang
  • CHEMICAL COMPOSITIONS AND METHODS OF USING SAME
    Publication number: 20180142286
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Application
    Filed: November 21, 2017
    Publication date: May 24, 2018
    Inventors: Dwayne L. DUNAWAY, Elizabeth A. MANRAO, Joseph M. BEECHEM, Rustem KHAFIZOV, Sanghamithra KORUKONDA, Yi DENG, Dae KIM, Mark GREGORY, Margaret HOANG
  • MULTIVALENT PROBES HAVING SINGLE NUCLEOTIDE RESOLUTION
    Publication number: 20170081713
    Abstract: The present invention relates to, among other things, polymer strands, probes, compositions, methods, and kits for enabling accurate and robust enzyme- and amplification-free detection of DNA and RNA with single base resolution (e.g., detection of a single nucleotide polymorphism (SNP), an insertion, and a deletion). The compositions, methods, and kits may further provide simultaneous detection of DNA and/or RNA and protein targets.
    Type: Application
    Filed: September 6, 2016
    Publication date: March 23, 2017
    Inventors: Dae KIM, Paul Martin ROSS, Gavin MEREDITH, Elizabeth A. MANRAO
  • METHODS AND COMPOSITIONS FOR GENERATING REFERENCE MAPS FOR NANOPORE-BASED POLYMER ANALYSIS
    Publication number: 20150132745
    Abstract: The present disclosure generally relates to the methods and compositions to efficiently analyze polymer characteristics using nanopore-based assays. Specifically disclosed is a method for generating reference signals for polymer analysis in a nanopore system, wherein the nanopore system has a multi-subunit output signal resolution. The method comprises translocating a reference sequence through a nanopore to generate a plurality of reference output signals, wherein each possible multi-subunit sequence that can determine an output signal appears only once in the reference sequence. The output signals are compiled into a reference map for nanopore analysis of an analyte polymer. Also provided are methods and compositions for calibrating the nanopore system for optimized polymer analysis.
    Type: Application
    Filed: April 19, 2013
    Publication date: May 14, 2015
    Applicant: University of Washington Through its Center for Commercialization
    Inventors: Jens Gundlach, Ian M. Derrington, Andrew Laszlo, Elizabeth Manrao