Abstract: The present application relates to compositions and methods for modulating expression of Family with Sequence Similarity 13 Member A (FAM13A) protein. In particular, the present application relates to nucleic acid-based therapeutics for reducing FAM13A gene expression via RNA interference and methods of using such nucleic acid-based therapeutics to reduce abdominal adiposity, reduce body weight, reduce fat mass, improve metabolic parameters including insulin resistance and non-alcoholic steatohepatitis (NASH), and reduce risk of myocardial infarction.

Abstract: An occluding device for occlusion of fluid flow through a body cavity is disclosed. The device comprises an embolization coil formed from at least one wire strand and having an initial tension. The embolization coil is defined by a primary coil formed into a secondary coil. The primary coil has a primary shape defined by a linear longitudinally extending coil having a plurality of helical turns and is helically wound into the secondary coil, wherein the secondary coil has a series of axially spaced apart loops. The axially spaced apart loops are larger than the helical turns of the primary coil. The embolization coil is movable between an expanded state for occlusion of a body cavity and a collapsed state for delivery or retrieval. An absorbent material, including at least one of cotton and regenerated cellulose, is attached to the embolization coil and extends therefrom. A kit is also included.

Abstract: An occluding device for occlusion of fluid flow through a body cavity is disclosed. The device comprises an embolization coil formed from at least one wire strand and having an initial tension. The embolization coil is defined by a primary coil formed into a secondary coil. The primary coil has a primary shape defined by a linear longitudinally extending coil having a plurality of helical turns and is helically wound into the secondary coil, wherein the secondary coil has a series of axially spaced apart loops. The axially spaced apart loops are larger than the helical turns of the primary coil. The embolization coil is movable between an expanded state for occlusion of a body cavity and a collapsed state for delivery or retrieval. An absorbent material, including at least one of cotton and regenerated cellulose, is attached to the embolization coil and extends therefrom. A kit is also included.

Abstract: The invention provides novel dendritic cell-associated lectin-like (DCAL-1) molecules, compositions and therapeutic methods of use. In one aspect, the invention provides isolated nucleic acid molecules that are capable of remaining hybridized to SEQ ID NO:1 or SEQ ID NO:3, including nucleic acid molecules that encode DCAL-1 polypeptides. In another aspect, the invention provides DCAL-1 polypeptides and portions thereof which are useful to stimulate T cell proliferation. In another aspect, the invention provides antibodies that specifically bind to DCAL-1 which are useful for promoting maturation of dendritic cells and for stimulating an immune response in vivo. In another aspect the invention provides methods of stimulating an immune response in an animal comprising introducing into the animal an anti-DCAL-1 antibody of the invention.

Abstract: An electronic Meeting system that utilizes unique methods and processes to create consecutive successions of audio video Meeting Sessions that occur in set blocks of time continuously 24 hours a day, 7 days a week, world-wide across all time zones. The system provides for a plurality of Members to be simultaneously matched real-time to other Members, using varied matching preferences, for a series of short Meetings to interact one on one for a fixed period of time in a controlled environment. The use of a live Countdown Clock Display allows for a spontaneous use of the system by visually communicating to Members that a Check-in Process for Meetings is always available.

Abstract: Apparatus and methods for positioning seismic streamers are described, one apparatus comprising a body, the body adapted to be connected to a seismic streamer, the body defining at least one flow passage there through, and a diverter adapted to selectively adjust flow through the flow passage. This abstract is provided to comply with the rules requiring an abstract, which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).

Abstract: In one aspect, there is a sports eye protector that includes a frame, a padding in communication with the frame and a sports grille releasably attachable to the frame. In another aspect, there is a sports eye protector that includes a frame and a sports grille releasably attachable to the frame, wherein the sports grille is compliant with a testing standard associated with a sport. In yet another aspect, there is a sports eye protector that includes a frame configured to be releasably attachable to any one of a plurality of sports grilles, wherein the plurality includes a first sports grille associated with a first sport and a second sports grille associated with a second sport.

Abstract: A method and system is provided for perforating a casing in a hydrocarbon well so as to avoid perforating in a direction where a cable resides. A mass of metallic material is clamped to the casing at a predetermined offset angle with respect to the cable. The angular position of the metallic mass is detected using a detector placed inside the casing. Then, a perforating gun is oriented based on the detected angular position of the metallic mass and the predetermined offset angle. Finally, the casing is perforated so as to avoid damage to the cable. The cable comprises a number of electrical conductors and is used to communicate with permanent sensors located on the cable in the vicinity of the casing to be perforated.