Abstract: Disclosed are agents for treating or preventing cancers. More particularly, the present invention discloses therapeutic combinations comprising antagonists of receptor of NF-?B (RANK) ligand and immune checkpoint molecules in methods and compositions for treating or inhibiting the development, progression or recurrence of cancers, including metastatic cancers.

Abstract: Disclosed are antigen-binding molecules that antagonize one or more functions of receptor activator of NF-?B (RANK) as well as methods of their manufacture and use. Applications are also disclosed in which these antagonist antigen-binding molecules are used in compositions and methods for treating or inhibiting the development of conditions associated with activation of the RANK ligand (RANKL)/RANK signaling pathway, for stimulating or augmenting immunity, for inhibiting the development or progression of immunosuppression or tolerance to a tumor and for inhibiting the development, progression or recurrence of cancer.

Abstract: A bushing assembly includes a washer that includes an opening defined therethrough. A cylindrical body includes a first end that is sized to be inserted within the washer opening and an opposite second end. The cylindrical body is fabricated from a smart material that is configured to selectively expand when at least a portion of the body is positioned within the washer opening.