Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

Abstract: An interface for positive pressure respiratory therapy includes a mask assembly having a mask seal and a mask shell. The mask assembly is positioned lower than and exposes a bridge of the user's nose. The mask seal includes first and second portions on respective first and second sides of a nasal region that contact opposing sides of the user's nose. The first and second portions each include supports that help maintain a shape of the mask seal. A pair of covers can be supported relative to the mask assembly and adjacent a respective one of the first and second portions of the mask seal. The covers limit expansion of the first and second portions of the mask seal in response to pressurized air within the mask seal. The supports of the first and second portions can transfer load from the mask seal to the covers.

Abstract: An interface for positive pressure therapy includes a mask assembly. The mask assembly includes a mask seal that is adapted to underlie the nose. The mask seal extends up the lateral sides of the nose. The mask seal has a primary seal below the nose and a secondary seal alongside the nose. The mask seal includes a rolling hinge that permits one portion of the mask seal to deform relative to another portion of the mask seal. In one configuration, the portion of the mask seal that underlies the nose is configured to deform relative to a lower portion of the mask seal.

Abstract: A method for monitoring performance of a ML system includes receiving a data stream via a processor and generating a first plurality of metrics based on the data stream. The processor also generates input data based on the data stream, and sends the input data to a machine learning (ML) model for generation of intermediate output and model output based on the input data. The processor also generates a second plurality of metrics based on the intermediate output, and a third plurality of metrics based on the model output. An alert is generated based on at least one of the first plurality of metrics, the second plurality of metrics, or the third plurality of metrics, and a signal representing the alert is sent for display to a user via an interface.

Abstract: Methods of treating bacterial infection in immunocompromised subjects and subjects with one or more underlying malignancies include administering a combination of meropenem and vaborbactam to the subject. Suitable subjects to be treated can include a subject with a history of ongoing leukemia or lymphoma, a subject that has had an organ transplant, stem cell transplant, bone marrow transplant, or splenectomy, a subject receiving immunosuppressive medications, a subject receiving bone marrow ablative chemotherapy, a subject with neutropenia and subject suffering from or having suffered from a malignancy.

Abstract: Methods of treating bacterial infection in immunocompromised subjects and subjects with one or more underlying malignancies include administering a combination of meropenem and vaborbactam to the subject. Suitable subjects to be treated can include a subject with a history of ongoing leukemia or lymphoma, a subject that has had an organ transplant, stem cell transplant, bone marrow transplant, or splenectomy, a subject receiving immunosuppressive medications, a subject receiving bone marrow ablative chemotherapy, a subject with neutropenia and subject suffering from or having suffered from a malignancy.

Abstract: Disclosed are conjugates of monomethyl fumarate and a carrier group or aminocarrier group, or a pharmaceutically acceptable salt thereof. In the conjugates, monomethyl fumarate acyl is covalently bonded to the carrier group or aminocarrier group through a carbon-oxygen bond that is cleavable in vivo. The carrier group may include a core, e.g., a monosaccharide, a sugar acid (e.g., acid monosaccharide), a sugar alcohol, or a catechin polyphenol. The aminocarrier group may include a core, e.g., an aminomonosaccharide. The carrier group or aminocarrier group may include, e.g., at least one short chain fatty acid acyl, at least one tryptophan analogue, at least one ketone body, or at least one pre-ketone body. Also disclosed are pharmaceutical compositions containing the conjugates and methods of their use.

Abstract: Methods of treating bacterial infection in immunocompromised subjects and subjects with one or more underlying malignancies include administering a combination of meropenem and vaborbactam to the subject. Suitable subjects to be treated can include a subject with a history of ongoing leukemia or lymphoma, a subject that has had an organ transplant, stem cell transplant, bone marrow transplant, or splenectomy, a subject receiving immunosuppressive medications, a subject receiving bone marrow ablative chemotherapy, a subject with neutropenia and subject suffering from or having suffered from a malignancy.

Abstract: The present disclosure is directed to membranes having improved performance parameters, specifically, to microfiltration, ultrafiltration, Nano filtration, reverse osmosis, submerged and bioreactor membranes having a portion with increased roughness (Ra) level.

Abstract: A tube picking mechanism is designed for use in an automated, ultra-low temperature (e.g. ?80° C. or ?135° C.) or cryogenic (e.g., about ?140° C. to ?196° C.) storage and retrieval system that stores biological or chemical samples. The samples are contained in storage tubes held in SBS footprint storage racks that are normally stored within an ultra-low temperature or cryogenic freezer compartment. The tube picking mechanism includes a tube picking chamber that is maintained at about ?80° C., about ?135° C. or at cryogenic temperatures in cryogenic applications. Active electrical and mechanical components are maintained in a compartment above and separate from the refrigerated, ultra-low temperature or cryogenic compartment.

Abstract: Disclosed is a driver training device that can be utilized to simulate the back of a moving vehicle. The training device can be utilized in a driver training program to help students learn proper distancing and how to avoid dangerous tailgating practices. A device can include a driver training apparatus comprising a taillight assembly that includes brake lights and/or other features to simulate the back of a moving vehicle. A training device can simulate the back of one or two vehicles, and can be powered by attachment to a lead vehicle or alternatively to a movable track. In addition, a training device can be adjustable to simulate a variety of differently sized vehicles and can be easily broken down into component sections for simple storage and transport.

Abstract: A tube picking mechanism is designed for use in an automated, ultra-low temperature (e.g. ?80° C. or ?135° C.) or cryogenic (e.g., about ?140° C. to ?196° C.) storage and retrieval system that stores biological or chemical samples. The samples are contained in storage tubes held in SBS footprint storage racks that are normally stored within an ultra-low temperature or cryogenic freezer compartment. The tube picking mechanism includes a tube picking chamber that is maintained at about ?80° C., about ?135° C. or at cryogenic temperatures in cryogenic applications. Active electrical and mechanical components are maintained in a compartment above and separate from the refrigerated, ultra-low temperature or cryogenic compartment.

Abstract: A method of testing a business application in an enterprise resource planning (ERP) system is provided. The business application is written using an application program interface (API) of the ERP system. The method comprises providing a test package configured to control testing of the business application. The method further comprises testing logic of the business application under the test package control using the same API of the ERP system which was used to create the business application.

Abstract: A tubing connector has first and second tubular legs joined together to provide a continuous fluid pathway therethrough with the fluid pathway having a bend of about 78 to 102 degrees therein. A foreshortened retention tab extends laterally from the tubing connector at about the bend in a direction opposed to the second leg of the tubing connector. A handle extends from the tubing connector at about a right angle to both the first and second legs and the retention tab. The tubing connector may be employed as a component of a fluid delivery set used with a pump for enteral or parenteral feeding of a patient.

Abstract: A two-component, heat reactive patch particularly useful for sealing gage and drain holes in automobile bodies which comprises an ionomer component and an olefinic/elastomeric component. The ionomer component contains an ionomeric copolymer of ethylene and an .alpha.,.beta.-ethylenically-unsaturated C.sub.3 -C.sub.8 carboxylic acid, a metallic coagent and a filler and, optionally, a non-ionomeric copolymer of ethylene. The olefinic/elastomeric component contains an uncrosslinked elastomer, a multifunctional acrylic monomer, and a free-radical curing agent.

Abstract: A fluid delivery set has three lengths of flexible tubing. The first length of flexible tubing at one end is connectable to or integral with a supply container for enteral or parenteral fluid, and at the other end is connected to the inlet of a drip chamber. The second length of flexible tubing is connected at one end to the outlet of the drip chamber, and at the other end to the inlet of a retention/connector device that has about a 90.degree. bend therein. The third length of flexible tubing is connected at one end to outlet of the retention/connector device, and at the other end is connectable to or integral with a means for introducing an enteral or parenteral fluid into the body of a patient. Preferably, a tension responsive pinch valve is operatively associated with the second length of flexible tubing.