Abstract: The disclosed technology includes systems and methods for automatically generating a dynamic system context diagram based on machine-readable code. A method can include receiving, at a rules engine, machine-readable code describing interactions among a plurality of applications in software architecture, evaluating, with the rules engine in communication with a system of record (SoR), compliance of the interactions among the plurality of applications according to the SoR, identifying, with the rules engine, and based on compliance evaluation, one or more dependencies among the plurality of applications, generating, with an output engine, a system context diagram image comprising a graphical representation of the plurality of applications with associated interactions and dependencies, and outputting, for display, the system context diagram image.

Abstract: The disclosed technology includes systems and methods for automatically generating a dynamic system context diagram based on machine-readable code. A method can include receiving, at a rules engine, machine-readable code describing interactions among a plurality of applications in software architecture, evaluating, with the rules engine in communication with a system of record (SoR), compliance of the interactions among the plurality of applications according to the SoR, identifying, with the rules engine, and based on compliance evaluation, one or more dependencies among the plurality of applications, generating, with an output engine, a system context diagram image comprising a graphical representation of the plurality of applications with associated interactions and dependencies, and outputting, for display, the system context diagram image.

Abstract: The disclosed technology includes systems and methods for automatically generating a dynamic system context diagram based on machine-readable code. A method can include receiving, at a rules engine, machine-readable code describing interactions among a plurality of applications in software architecture, evaluating, with the rules engine in communication with a system of record (SoR), compliance of the interactions among the plurality of applications according to the SoR, identifying, with the rules engine, and based on compliance evaluation, one or more dependencies among the plurality of applications, generating, with an output engine, a system context diagram image comprising a graphical representation of the plurality of applications with associated interactions and dependencies, and outputting, for display, the system context diagram image.

Abstract: The invention relates, in part, to methods and systems with which to identify guide RNAs (gRNAs) and methods and systems with which to prepare, design, and generate gRNAs and minimally repetitive arrays of gRNAs.

Abstract: The invention concerns compounds of Formula I, or a pharmaceutically acceptable salt thereof, where R1, n, R2, R3, and R4 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of EphB4 kinases.