Patents by Inventor Elizabeth DiBlasio-Smith

Elizabeth DiBlasio-Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Secreted proteins and polynucleotides encoding them
    Publication number: 20040248256
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: April 9, 2004
    Publication date: December 9, 2004
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa Collins-Racie, David Merberg, Cheryl Evans, Maurice Treacy, Michael J. Agostino, Robert J. Steininger, Michael R. Bowman, Elizabeth DiBlasio-Smith, Angela Widom
  • HUMAN CHORDIN-RELATED PROTEINS AND POLYNUCLEOTIDES ENCODING THEM
    Publication number: 20020197666
    Abstract: Novel human chordin-related proteins and polynucleotides encoding them are disclosed.
    Type: Application
    Filed: August 13, 1999
    Publication date: December 26, 2002
    Inventors: KENNETH JACOBS, JOHN M. MCCOY, EDWARD R. LAVALLIE, LISA A. COLLINS-RACIE, DAVID MERBERG, MAURICE TREACY, ELIZABETH DIBLASIO-SMITH, ANGELA WIDOM
  • Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules
    Patent number: 6143524
    Abstract: Provided is a fusion molecule comprising a DNA sequence encoding a thioredoxin-like protein fused to a DNA sequence encoding a second peptide or protein. The peptide or protein may be fused to the amino terminus of the thioredoxin-like molecule, the carboxyl terminus of the thioredoxin-like molecule, or within the thioredoxin-like molecule, for example at the active-site loop of the molecule. The fusion molecule may be modified to introduce one or more metal-binding/chelating amino-acid residues to aid in purification. Expression of this fusion molecule under the control of a regulatory sequence capable of directing its expression in a desired host cell, produces high levels of stable and soluble fusion protein. The fusion protein, located in the bacterial cytoplasm, may be selectively released from the cell by osmotic shock or freeze/thaw procedures. It may be optionally cleaved to liberate the soluble, correctly folded heterologous protein from the thioredoxin-like portion.
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: November 7, 2000
    Assignee: Genetics Institute, Inc.
    Inventors: John McCoy, Elizabeth DiBlasio-Smith, Kathleen Grant, Edward R. LaVallie
  • Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules
    Patent number: 5646016
    Abstract: Provided is a fusion molecule comprising a DNA sequence encoding a thioredoxin-like protein fused to a DNA sequence encoding a second peptide or protein. The peptide or protein may be fused to the amino terminus of the thioredoxin-like molecule, the carboxyl terminus of the thioredoxin-like molecule, or within the thioredoxin-like molecule, for example at the active-site loop of said molecule. The fusion molecule may be modified to introduce one or more metal-binding/chelating amino-acid residues to aid in purification. Expression of this fusion molecule under the control of a regulatory sequence capable of directing its expression in a desired host cell, produces high levels of stable and soluble fusion protein. The fusion protein, located in the bacterial cytoplasm, may be selectively released from the cell by osmotic shock or freeze/thaw procedures. It may be optionally cleaved to liberate the soluble, correctly folded heterologous protein from the thioredoxin-like portion.
    Type: Grant
    Filed: December 10, 1993
    Date of Patent: July 8, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John McCoy, Elizabeth DiBlasio-Smith, Kathleen Grant, Edward R. LaVallie