Patents by Inventor Elizabeth E. Wicks

Elizabeth E. Wicks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BLOOD BRAIN BARRIER MODEL AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20220106572
    Abstract: Provided herein is an in vitro model of the blood brain barrier. In some embodiments, the model includes: an endothelial cell layer, and brain tissue layer comprising neuronal cells, and optionally one or more of astrocytes, pericytes, oligodendrocytes, and microglia. In some embodiments, the model further comprises a porous membrane between said endothelial cell layer and the neuronal cell layer. A microfluidic device comprising the same and methods of use thereof are also provided.
    Type: Application
    Filed: December 9, 2021
    Publication date: April 7, 2022
    Inventors: Robert T. Wicks, Anthony Atala, Goodwell Nzou, Elizabeth E. Wicks
  • Blood brain barrier model and methods of making and using the same
    Patent number: 11230702
    Abstract: Provided herein is an in vitro model of the blood brain barrier. In some embodiments, the model includes: an endothelial cell layer, and brain tissue layer comprising neuronal cells, and optionally one or more of astrocytes, pericytes, oligodendrocytes, and microglia. In some embodiments, the model further comprises a porous membrane between said endothelial cell layer and the neuronal cell layer. A microfluidic device comprising the same and methods of use thereof are also provided.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: January 25, 2022
    Assignee: Wake Forest University Health Sciences
    Inventors: Robert T. Wicks, Anthony Atala, Goodwell Nzou, Elizabeth E. Wicks
  • BLOOD BRAIN BARRIER MODEL AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20190194625
    Abstract: Provided herein is an in vitro model of the blood brain barrier. In some embodiments, the model includes: an endothelial cell layer, and brain tissue layer comprising neuronal cells, and optionally one or more of astrocytes, pericytes, oligodendrocytes, and microglia. In some embodiments, the model further comprises a porous membrane between said endothelial cell layer and the neuronal cell layer. A microfluidic device comprising the same and methods of use thereof are also provided.
    Type: Application
    Filed: August 4, 2017
    Publication date: June 27, 2019
    Inventors: Robert T. Wicks, Anthony Atala, Goodwell Nzou, Elizabeth E. Wicks