Patents by Inventor Elizabeth Eckman

Elizabeth Eckman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fusion proteins for protein delivery
    Patent number: 6287817
    Abstract: A protein conjugate consisting of antibody directed at the pIgR and A1AT can be transported specifically from the basolateral surface of epithelial cells to the apical surface. This approach provides us with the ability to deliver a therapeutic protein directly to the apical surface of the epithelium, by targeting the pIgR with an appropriate ligand. Thus, the highest concentration of the antiprotease will be at the apical surface, where it can do the greatest good in accelerating the inflammatory response.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: September 11, 2001
    Assignee: Case Western Reserve University
    Inventors: Pamela B. Davis, Thomas Ferkol, Elizabeth Eckman, John Schreiber, John M. Luk
  • Bifunctional molecules for delivery of therapeutics
    Patent number: 6261787
    Abstract: A bifunctional molecule consisting of a therapeutic molecule and a ligand which specifically binds a transcytotic receptor can be transported specifically from the basolateral surface of epithelial cells to the apical surface. This approach provides the ability to deliver a therapeutic molecule directly to the apical surface of the epithelium, by targeting the transcytotic receptor with an appropriate ligand. Thus, the highest concentration of the therapeutic molecule will be at the apical surface, where it can have the greatest therapeutic effect.
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: July 17, 2001
    Assignee: Case Western Reserve University
    Inventors: Pamela B. Davis, Thomas W. Ferkol, Jr., Elizabeth Eckman
  • Fusion proteins for protein delivery
    Patent number: 6072041
    Abstract: A protein conjugate consisting of antibody directed at the pIgR and A.sub.1 AT can be transported specifically from the basolateral surface of epithelial cells to the apical surface. This approach provides us with the ability to deliver a therapeutic protein directly to the apical surface of the epithelium, by targeting the pIgR with an appropriate ligand. Thus, the highest concentration of the antiprotease will be at the apical surface, where it can do the greatest good in accelerating the inflammatory response.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: June 6, 2000
    Assignee: Case Western Reserve University
    Inventors: Pamela B. Davis, Thomas Ferkol, Elizabeth Eckman, John Schreiber, John M. Luk