Patents by Inventor Elizabeth Ellen Sikorski

Elizabeth Ellen Sikorski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Serine protease variants having amino acid deletions and substitutions
    Patent number: 6908757
    Abstract: The present invention relates to variants of serine proteases having decreased immunogenicity relative to their corresponding wild-type proteases. More particularly, the present invention relates to variants having a modified amino acid sequence of a wild-type amino acid sequence, wherein the modified amino acid sequence comprises a deletion and, optionally, a substitution of one or more specifically identified positions corresponding to subtilisin BPN?. The invention further relates to mutant genes encoding such variants and cleaning and personal care compositions comprising such variants.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: June 21, 2005
    Assignee: The Procter & Gamble Company
    Inventors: Donn Nelton Rubingh, Elizabeth Ellen Sikorski, Paul Elliott Correa
  • Subtilisin protease variants having amino acid substitutions in defined epitope regions
    Patent number: 6586223
    Abstract: The present invention relates to variants of subtilisin-like proteases having decreased immunogenicity relative to their corresponding wild-type proteases. More particularly, the present invention relates to variants having a modified amino acid sequence of a wild-type amino acid sequence, wherein the modified amino acid sequence comprises a substitution of one or more epitope regions. The invention further relates to mutant genes encoding such variants and cleaning and personal care compositions comprising such variants.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: July 1, 2003
    Assignee: The Procter & Gamble Company
    Inventors: Elizabeth Ellen Sikorski, Donn Nelton Rubingh
  • Subtilisin protease variants having amino acid deletions and substitutions in defined epitope regions
    Patent number: 6586224
    Abstract: The present invention relates to variants of subtilisin-like proteases having decreased immunogenicity relative to their corresponding wild-type proteases. The present invention further relates to such variants additionally having one or more amino acid substitutions in one or more epitope regions or additionally having one or more stabilizing substitutions. The invention further relates to mutant genes encoding such variants and cleaning and personal care compositions comprising such variants.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: July 1, 2003
    Assignee: The Procter & Gamble Company
    Inventors: Donn Nelton Rubingh, Elizabeth Ellen Sikorski
  • Serine protease variants having amino acid substitutions
    Patent number: 6569663
    Abstract: The present invention relates to variants of serine proteases having decreased immunogenicity relative to their corresponding wild-type proteases. More particularly, the present invention relates to variants having a modified amino acid sequence of a wild-type amino acid sequence, wherein the modified amino acid sequence comprises a substitution of one or more specifically identified positions corresponding to subtilisin BPN′. The invention further relates to mutant genes encoding such variants and cleaning and personal care compositions comprising such variants.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: May 27, 2003
    Assignee: The Procter & Gamble Company
    Inventors: Donn Nelton Rubingh, Elizabeth Ellen Sikorski, Paul Elliott Correa