Abstract: Provided herein are compounds of the Formula (I): (I) and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein Rx, Ry, W, X, Y, Z, Ring A and (AA) have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Provided is a computerized system and method of organizing and navigating through a management system in a hierarchal visualization structure. The elements of the management system are represented in cells in the form of a periodic table. The elements are classified and organized into one or more sets of groups stored at a first hierarchal level. Each cell displays general identification information regarding an element stored at a second hierarchal level including a textual abbreviation representing the element. Details regarding each element stored at third hierarchal level are displayed when one of the cells is selected. More specific information regarding each detail stored at a fourth hierarchal level is displayed when a detail is selected.

Abstract: Provided is a computerized system and method of organizing and navigating through a management system in a hierarchal visualization structure. The elements of the management system are represented in cells in the form of a periodic table. The elements are classified and organized into one or more sets of groups stored at a first hierarchal level. Each cell displays general identification information regarding an element stored at a second hierarchal level including a textual abbreviation representing the element. Details regarding each element stored at third hierarchal level are displayed when one of the cells is selected. More specific information regarding each detail stored at a fourth hierarchal level is displayed when a detail is selected.

Abstract: A shopping cart immobilizing cradle device, as shown in FIG. (1), in the preferred embodiment having a base of the ramp (3) which inclines upward to the top of the ramp (9) and having tapering inwards ramp walls (4) on both sides of the entire ramp. The top of the ramp (9) feeds into cradle (2) having parallel cradle walls (5) on both sides of the cradle (2). Nylon retrieval strap (11) is permanently attached to the device by friction after being pressed into slot (7) while plastic hook (12) is permanently attached to the loose end of the strap (11). Foot insertion slot (6) has a back wall (10) to stop the toe of the foot. Device bottom (1) is placed on top of the standing surface by lowering the device by means of the retrieval strap (11). The base of the ramp (3) is properly positioned when centered just in front of either front castor wheel of the shopping cart. The user places the front of their foot into insertion slot (6) until the toe of the shoe touches the back wall (10).