Abstract: A syringe fixture for holding a syringe in a test system, the fixture comprising a main housing comprising a first chamber, a second chamber, and an opening extending from the first chamber to the second chamber, wherein the first chamber comprises a first plurality of walls and a second plurality of walls forming a housing for at least a needle of the syringe, wherein the second chamber is configured to hold at least a flange portion of the syringe and the second chamber comprises a cover to enclose at least the flange portion of the syringe; and a base portion having a support, wherein the base portion is configured to receive a portion of a plunger rod, and wherein the base portion includes at least one geometric feature configured to allow or impart a rotational motion on the portion of the plunger rod received in the base portion.